查询词典 carcinogenesis

Methods DMBA induced golden hamster cheek pouch carcinogenesis model,Resin vascular cast and prepared-Chinese-ink injection were used in this study to detect the angiogenesis of carcinogenesis.

采用DMBA诱导的金黄地鼠颊囊癌变动物模型、树脂血管灌注及墨汁血管灌注检测癌变时的血管生成情况。

Objectives To observe the expressing of α-SMA dynamically and to analyse the correlativity between the expression and the carcinogenesis during the evolution of golden hamster cheek pouch carcinogenesis.

提 要 目的动态观察金地鼠颊癌变过程中α-SMA表达规律，并分析其表达和癌变间的相关性。

The other markers related lesion progression were cyclinB1 and IMPI in esophageal carcinogenesis and p16 in gastric cardia carcinogenesis.

单一抗体对食管和贲门癌检出率较低，p53在癌血清中的表达阳性率在所有抗原中最高，在食管癌和贲门癌患者中分别为23％（13／57）和21％（9／43）。

Objective To explore livin, MTA1 and the caspase3 protein expression, their correlation and clinical pathology in colon cancer Methods The expressions of livin, MTA1 and caspase3 protein in 88 cases of colon cancer were detected by immunohistochemistry stainingResults Livin, caspase3 protein and MTA1 positive expression rates in colon cancer tissues were more than those in tissues beside the cancer Furthermore there were obvious relevance between livin protein, MTA1 positive expression rate and degree of histodifferentiation and lymph node metabasis and between caspase3 protein positive expression rate and degree of histodifferentiation of colon cancer Caspase3 protein expression had prominent inverse correlation with the livin expressionConclusions ①Over expression of livin having inhibtion on colon cancer is one of important factors of colon carcinogenesis ②Caspase3 protein expression in colon cancer tissues is inhibited to less and has prominent inverse correlation with livin expression Accordingly, suppressing caspase3 protein activity is one of channels, by which livin promotes colon carcinogenesis ③MTA1 plays the important role in histodifferentiation degree and lymph node metastasis of colon cancer

采用免疫组织化学染色方法检测88例结肠癌组织中Livin，Caspase3 及MTA1的表达情况。结果（1）结肠癌组织中Livin的阳性表达率显著高于癌旁组织，且Livin的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。（2）结肠癌组织中Caspase3蛋白的阳性表达率显著高于癌旁组织，且Caspase3蛋白的表达与结肠癌的组织分化程度显著相关。（3）结肠癌组织中MTA1的阳性表达率显著高于癌旁组织，且MTA1的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。（4）Caspase3蛋白的表达又与Livin的表达呈显著负相关。结论（1）Livin在结肠癌组织中过表达，它可能是促进结肠癌发生的重要因素之一。（2）Caspase3蛋白在结肠癌组织中表达被抑制而降低，且与Livin的表达呈负相关。因此，抑制Caspase3蛋白的活性是Livin促进结肠癌发生的途径之一。（3）MTA1对结肠癌的组织分化及淋巴转移发挥重要作用。

Pokemon protein expression is correlated with the carcinogenesis of gastric carcinoma, maybe it correlate with the carcinogenesis and progression of atypic hyperplasia of gastric mucosa, gastric carcinoma.

Pokemon蛋白的表达与胃癌的发生密切相关，可能参与了胃黏膜不典型增生及胃癌的发生发展。

The changes of actin expression in atypical hyperplasia are possibly correlated with carcinogenesis of breast cancer, and myoepithelial cells may play a role in carcinogenesis of breast cancer.

乳腺不典型增生时肌动蛋白表达的变化可能与乳腺癌的发生有关，肌上皮细胞可能参与了乳腺癌的发生。

The effects of phenolic acid compounds in vegetables and fruits on metabolicactivation of BaP in rats,as well as 〓 and TCA induced lipid peroxidation inmouse and Salmonella typhimurium TA104 cells were investigated using DNAadducts as a biomarker to assess DNA damage induced by xenobiotic carcinogens.BaP was used to study the genotoxic carcinogenesis,while 〓 and TCA were usedto study the non-genotoxic carcinogenesis.The possible protection mechanisms ofphenolic acid compounds on DNA damage were studied.

本研究根据化学致癌过程的遗传毒性和非遗传毒性机理，以DNA加合物作为机体接触外来化学物而导致DNA损伤的生物学标志物，通过观察酚酸类化合物对大鼠体内BaP活化代谢以及〓和TCA诱导小鼠肝微粒体脂质过氧化的影响，及酚酸类化合物对BaP和TCA诱导的沙门氏菌TA100和TA104形成DNA加合物的影响，探讨蔬菜、水果中酚酸类化合物对外来化学物诱导的DNA损伤的保护机制。

On the other hand, flow cytometry was employed to detect the action of paclitaxel to cell cycle and apoptosis. Reverse transcription polymerase chain reaction is employed to detect the influence of paclitaxel on Survivin mRNA expression. The purpose of the study is to provide theoretical basis to carcinogenesis, progress, metastasis, angiogenesis and clinical chemotherapy of paclitaxel on TSCC.

采用流式细胞仪检测紫杉醇对舌癌细胞细胞周期的影响及应用逆转录聚合酶链反应(reverse transcription polymerase chain reac-tion，RT-PCR)检测紫杉醇对舌癌中Survivin mRNA的影响，为研究舌鳞癌的发生、发展机制，舌癌的转移及新生血管形成，及临床应用紫杉醇抗舌癌提供理论依据。

Objective: To evaluate the chemo-preventive effect of PPARγ agonist Rosiglitazone in rat model of stomach carcinogenesis.

目的：探讨Rosiglitazone对化学致癌剂MNNG诱导的大鼠胃癌发生的影响。

However the direct evidence of areca associated carcinogenesis has not been classified.

在先前的研究中虽已发现槟榔对细胞及组织的伤害和诱导某些蛋白质表现量上的差异，但并没有以高产能的方式探讨其对细胞中蛋白质表现的直接影响。

Eight cases of simple chordee of penis were adopted urethral extending.9 cases of severe simple chordee of penis were adopted primary urethroplasty.

8例单纯性阴茎下弯患者采取尿道延伸术，9例重度阴茎下弯患者采取切断尿道矫直阴茎一期尿道成形术。

She is a daintily dressed young lady.

她是个装饰娇艳的少女。