bone up

Pathological observations showed that the bone marrow and spleen of non-treated IMAA mice demonstrated typical aplastic anemia pattern, including bone marrow failure, marked splenatrophy, but the bone marrow and lymphoid tissues in the IMAA mice of irradiation-treated group were recovered to normal at day 28 after treatment.

结果表明：①IMAA组小鼠活存率为12.5%，平均存活时间为27.4 13.4天，照射治疗组活存率为100%，平均存活时间60天以上，单纯照射组无死亡；②外周血白细胞数：IMAA组呈进行性下降，直至死亡，照射治疗组第10天与免疫再障组相似，以后开始缓慢回升，基本上达到治疗前水平；③红细胞比容：未治疗IMAA组于14天后呈进行性降低，至第35天比实验前减低2/3，照射治疗组与单纯照射组一样，第14天有轻度减低随后升高，至35天接近正常；④骨髓有核细胞数：IMAA组呈进行性减低，无恢复趋势，照射治疗组于一过性减低后迅速增加，第28天达到正常水平；⑤骨髓和淋巴组织病理形态观察：IMAA组小鼠呈典型再生障碍性贫血病理改变，骨髓造血衰竭，脾脏明显萎缩，而照射治疗组于第28天骨髓和脾淋巴脏组织基本上恢复正常。

Orbital LCH frequently occurs in the supratemporal frontal bone as stem cell precursors of Langerhans cells are located in hematopoetic bone marrow in the frontal bone.

眼眶朗格汉斯组织细胞症最常发生在颞上额骨，因为朗格汉斯的干细胞母体位于额骨的生血骨髓内。

Methods Rats aging 4 weeks were immobilized by limb-tail fixation for 2 and 4 weeks respectively, and then the wet weight, gray weight, bone mineral density of femurs and tibiae were measured, the histopathological and histomorphological parameters also were detected, which were used to evaluate the effect of immobilization on bone content and bone structure of femurs and tibiae in growing rats. The VDR expression of femurs and tibiae in the growing rats was evaluated by immunohistochemistry and image analysis.

通过腿－尾固定法对4周龄幼鼠分别进行右后肢2周和4周制动，采用股骨湿重、灰重、骨密度测量，骨组织病理学和骨组织形态学参数测定等方法对比评价制动对幼鼠制动侧股骨和胫骨的骨量、骨结构的影响，采用免疫组织化学和图象分析方法检测制动对幼鼠骨VDR表达的影响。

MAIN OUTCOME MEASURES:①At week 9, recovery of bone mass was recorded. Height of alveolar bone, density of bone trabecula and osseointegration were observed by X-ray film.

主要观察指标：①种植术后第9周时观察各组骨量的恢复情况、X射线片观察牙槽骨高度、骨小梁致密度及骨整合情况。

Results Compared with model group,the volumes of bone trabecula were increased in both Bushenfugai group and nilestriol group with decreased bone absorbing surface.The bone forming surface and rate of mineralization deposition of nilestriol group were decreased,while there were no significant changes in Bushenfugai group.

结果与模型组比较，补肾富钙中药组和尼尔雌醇组的骨小梁体积显著增加，骨吸收表面减少；尼尔雌醇组的骨形成表面和矿化沉积率下降，但在补肾富钙中药组则无显著变化。

No difference were found in all dose Epimedium total flavonoids groups,percent of bone trabecula area and number of bone trabecula showed increasing pattern and resolving powder of bone trabecula showed decreasing pattern.

淫羊藿总黄酮三个剂量组之间没有差异，但在骨小梁面积百分数、骨小梁数量上有上升的趋势，骨小梁分离度则有下降的趋势。

Results As compared with control group,the bone trabecula was thinner in experiment group,and the bone structure was rarefaction and disorder, with less bone mass.

结果 与对照组比较，实验组骨小梁纤细，结构稀疏紊乱，骨量少，部分骨小量断裂，成骨细胞和破骨细胞数量均增多，骨陷窝内破骨细胞活跃；骨密度下降。

Bone defects and nonunion are common problem in orthopaedic surgery, the management for these conditions is traditionarily autogenous bone graft, which is defect on the aspect of local complication and limited by bone volume in donor sites.

骨缺损、骨折不愈合是骨科临床常见的问题，传统的治疗方法是自体骨移植，但存在局部并发症和供骨数量不足等缺陷。

There are 21 cases in investigative group,In all 21 cases,the lesions of 7 cases were in vertebra,7 cases were in plat bone,4 cases were in short tubiform bone,and the lesions of 3 cases were in clavicle,pubic bone,astragulus.

其中研究组21例，包括位于脊椎骨者7例，位于扁骨者7例，短管状骨4例，锁骨、耻骨、距骨各1例。

objective to investigate the existence of the erythropoiesis inhibitors.methods the present study included twelve undialyzed esrd patients with anemia.the sera from the uremic patients were added to cfu-e and bfu-e culture in the concentrations ranging from 1.25% to 5%.in vitro cfu-e and bfu-e growth in the presence of sera from esrd patients was compared with in the presence normal human subjects with the use of normal mice bone marrows.results the effects of the sera from uremic patients on cfu-e and bfu-e colony growth in concentrations ranging from 1.25% to 5% were investigated to be dose-dependent.the effect increased with the concentrations increasing of the sera（p＜0.05）.there were not significant inhibitory effect on the cfu-e and bfu-e growth of mice bone marrow in vitro from sera of the normal subjects.conclusion the erythropoiesis inhibitors exist in uremic sera which has a dose-dependent inhibitive effects on the growth cfu-e and bfu-e of normal mice bone marrow cells.

选择12例尿毒症肾性贫血未透析患者为试验组，另选正常健康体检者12例为正常对照组，将实验组、正常对照组血清分别稀释成不同终浓度，采用甲基纤维素细胞培养的方法对小鼠骨髓细胞进行培养，对比不同浓度血清组红系集落形成单位、红系爆式形成单位的集落数。结果在实验组中，与血清浓度为0的浓度组相比，与各浓度组血清共同培养的小鼠骨髓cfu-e和bfu-e的集落数均明显减少，且随血清浓度的增加，小鼠骨髓cfu-e和bfu-e的集落数逐渐减少，各浓度组间差异有显著性（p＜0.05）。结论尿毒症患者血清抑制小鼠骨髓红系祖细胞集落形成，随患者血清浓度的增加，抑制作用增强，具有剂量依赖性。

The French are not suggesting a new EU treaty, but they have plenty of other wheezes.

法国人并不是在建议签署一个新的欧盟条约，但他们有许多其他的阴谋。

This letter was written by my brother.

这封信是我弟弟写的。