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RESULTS:(1) ET-1 could increase total protein production, surface area, ERKs activity and ［Ca2+］i in cultured cardiomyocyte in dose-dependent manner at concentrations ranging from 10-9 to 10-7 mol/L. And this effect could be abolished by BQ123, an antagonist of ETA receptor, partly inhibited by PTX, but not by BQ788, an antagonist of ETB receptor.（2）The activation of ERKs and the increase of ［Ca2+］i induced by ET-1 were obviously inhibited by PD98059, a selective ERKs kinase inhibitor, and nifedipine, a calcium channel blocker, respectively. Both antagonists partially inhibited ET-1-stimulated cardiomyocyte hypertrophic response.(3) Staurosporine, a selective PKC inhibitor, could inhibit ET-1-stimulated cardiomyocyte hypertrophic response and increase of ［Ca2+］i, but not affect the activation of ERKs.

结果： ①ET-1浓度依赖性增加新生大鼠心肌细胞蛋白质含量和心肌细胞表面积、ERKs活性及［Ca2+］i浓度，以上作用可被ETA受体拮抗剂BQ123所完全抑制，被百日咳毒素部分抑制，而ETB受体拮抗剂BQ788则无效；②ERKs激酶特异性抑制剂PD98059可完全抑制ET-1激活ERKs的作用，钙通道拮抗剂硝苯地平可明显抑制ET-1介导的［Ca2+］i浓度增加，但二者皆仅部分抑制ET-1介导的心肌细胞肥大反应；③蛋白激酶C选择性抑制剂staurosporine并不能明显抑制ET-1介导的ERKs激活，但可抑制ET-1介导的的［Ca2+］i浓度增加及心肌细胞肥大反应。

METHODS: Under the same conditions, the samples of titanium alloy and CFR/PEEK were placed in the fresh human blood so as to determine blood compatibility via haemolysis rate, platelet activation level, and leukocyte activation level.

在相同条件下，将钛合金和碳纤维增强聚醚醚酮2种材质的试件分别放置于新鲜人血中，通过观察溶血率，血小板激活程度以及白细胞激活程度判断材料的血液相容性。

The activation energy for deformation in W18Cr4V high speed steel, 40CrMnNiMo tool steel for plastic molding and AISI H13 hot-work tool steel are investigated intensively. The investigation shows that the activation energy for deformation of both 40CrMnNiMo tool steel for plastic molding and AISI H13 hot-work tool steel decrease with the increasing of temperature.

分别将这两种钢的变形激活能数学模型用于蠕变模型，并采用这一改进后的蠕变模型对W18Cr4V高速钢和40CrMnNiMo塑模钢的热变形流变应力进行预测，结果表明，此模型不仅能精确描述蠕变条件下工模钢的流变应力变化规律，也能精确描述工模钢非蠕变条件下的流变应力。

The balanced bilingualism's conflicts control ability are better than the unbalanced bilingualisms' at levels of response activation in the interference condition of Chinese color words; the balanced bilingualism and the unbalanced bilingualism have the same conflicts control ability at the levels of perceptual processing in the interference condition of Chinese color words; The balanced bilingualism's conflicts control ability are better than the unbalanced bilingualisms' at levels of perceptual processing in the interference condition of English color words; the balanced bilingualism and the unbalanced bilingualism have the same conflicts control ability at the levels of response activation in the interference condition of English color words.

在中文色词干扰条件下，在心理加工的知觉阶段，熟练双语者和不熟练双语者的抑制控制能力没有差异；在心理加工的反应阶段，熟练双语者的双语抑制控制能力明显强于不熟练双语者；在英文色词干扰条件下，在心理加工的知觉阶段，熟练双语者的双语抑制控制能力明显强于不熟练双语者；在心理加工的反应阶段，熟练双语者和不熟练双语者的抑制控制能力没有差异。

The calculated results with B3LYP/6-31G-DFT show:(1)the molecular total energy of benzofuroxan is lower than that of o-dinitrosobenzene;(2)the activation energy(Ea+=51.0kJ/mol)of forward reaction that benzofuroxan isomerises into o-dinitrosobenzene,is in agreement with the experimental(58.6kJ/mol)provided by reference,and the activation energy(Ea-=4.6kJ/mol)of back-ward reaction is very small.It is concluded thereby that benzofuroxan is more stable than o-dinitrosobenzene.In addition,the corresponding ab initio calculations at the level of HF/3-21G,HF/6-31Gand MP2/6-31G//6-31G were completed,and it was found that the calculated results by B3LYP-DFT method are superior to those from ab initio calculation.

结果表明，苯并氧化呋咱的分子总能量比邻二亚硝基苯的低；由苯并氧化呋咱异构为邻二亚硝基苯的正向反应活化能（Ea+=51.0kJ/mol），与文献实测值（58.6kJ/mol）较接近，而其逆向反应活化能（Ea-=4.6kJ/mol）很小，从而揭示了苯并氧化呋咱比邻二亚硝基苯更稳定·此外，进行了HF/3-21G、HF/6-31G和MP2/6-31G//6-31G水平下相应的计算，发现B3LYP-DFT的结果较abinitio为优。

Baicalin could inhibit the initial-period and mid-period activation of mouse T lymphocytes stimulated by Con A or PDB,which suggests that baicalin have the inhibitory effect on signaling pathway of T lymphocytes activation and be a potential effective immunoinhibitory agent.

结论黄芩苷能够明显抑制多克隆刺激剂Con A或PDB诱导的T细胞早期和中期活化，且呈明显的量效关系。提示黄芩苷在T细胞活化过程的信号转导中有抑制作用，从而可以通过抑制T淋巴细胞的活化，发挥免疫抑制作用，是一种潜在的免疫抑制剂。

EGFR activation induced activation of several downstream intracellular substrates, leading to mitogenic signaling and other tumor-promoting cellular activities.

在许多不同的人类癌症中，包括口腔癌，EGFR有过度表现的情形。

This paper deals with and summarizes the research and importance of ductile shear zones and presents the future direction and aim for the research of the ductile shear zones around the world. Four aspects of studies of the ductile shear zones have been proposed in this paper as follows:(1) The stress environment including the mineral assemblages, deformation, stress-shearing parameters;(2) The major element sequence and activation under condition of stress;(3) The variations of trace elements and REE, their transportation distributions under strong natural deformation as well as variations of mineral crystal parameters, which can also control the element changes during the ductile deformation;(4) The relationship between element migrations, activation and stress, which will present the new evidences for the studies of dynamic diagenesis and mineralization as well as the studies of evolution of ductile shear zones developed in middle and low levels.(5) The analysis of elements and isotopes in mylonites on the micro-scale are crucial for the understanding of component migrations during the mylonization.

对韧性剪切带及其变形岩石的研究现状和研究意义进行系统的综述，提出了未来韧性剪切带及其糜棱岩的研究方向和目标：①系统研究糜棱岩中主要造岩矿物组合及其变形特征，计算剪切变形岩石的应力－应变参数，搞清韧性剪切带所处的应力应变环境；②系统研究韧性剪切带岩石在天然分强剪切应力作用条件下常量元素迁移机制及活化转移的应力排序问题；③系统研究剪切变形作用过程中岩石化学组成的微量和稀土元素变化，讨论强变形条件下岩石中微量元素活化和迁移规律，深入探讨微量元素迁移的动力控制，包括稀土元素配分变化的应力制约以及应变矿物晶格化学变化行为及其对其寄主的变形岩石元素在应变过程中迁移变化的制约和影响；④从理论上探讨天然强剪切应变条件下岩石中组分活化、转移与应力的因果联系，为深入探讨韧性剪切带动力成岩作用提供理论的科学依据，为探讨中、下地壳中韧性剪切带的形成和演化提供科学依据，同时为韧性剪切变形作用条件下成岩、成矿地球化学作用提供理论和实验依据；⑤现代分析技术如激光同位素原位分析以及激光ICP-MASS分析技术对研究变形域内的岩石的元素和同位素的活化迁移规律，对深刻揭示糜棱岩化过程中的元素活化迁移机制提供更高质量的地球化学证据具有重要的作用。

The activation ofα_1-adrenergic receptors synergizedσ_1 receptors activation in the prelimbic cortex.

而在海马PREGS则只通过激活σ1受体从而增强PKA的活性。

For the purpose of studying the effect of different activation and pyrogenation conditions on the porosity of carbon produced from waste tyre rubber pyrolysed in the pilot-scale rotary kiln pyrolyzer, a activation furnace was designed in which the tyre carbons was activated.

为了研究不同热解工况和活化工况对废轮胎活化炭品质的影响，运用自行设计的活化炉对废轮胎热解炭进行了活化实验。

Chinese traditional virtue is humility and wariness,the compliment and praise to the others should be declination

中国人的传统美德是谦虚谨慎，对别人的恭维和夸奖应是推辞。如

We bought this house on the never-never.

我们以分期付款的方式买下这座房子。