查询词典 Ra

TNF - ais one of important nosogenetic factors of RA. Insulin - like Growth Factor - 1 (IGF - 1) is a kind of polypeptid, which has similar structure to insulinogen.

胰岛素样生长因子(Insulin-like Growth Factor，IGFs)是一类结构上类似胰岛素原的多肽，在细胞的生长、分化及代谢的调节中起重要作用。

NADP-Dependent Retinol Dehydrogenase/Reductase identified from rabbit liver cytosol is involved in oxidoreduction between retinol and retinal with high activity. Therefore, NRDR plays an important role in modulation of the retinoids and RA homeostasis.

辅酶Ⅱ依赖性视黄醇脱氢/还原酶NADP(H-Dependent Retinol Dehydrogenase /Reductase NRDR是黄东阳教授等从兔肝中发现并纯化的一种酶，具有很高的催化视黄醛和视黄醇之间氧化还原反应的活性，对体内类视黄醇和维甲酸的代谢平衡起着重要的调节作用。

It has great value to diagnose RA when pannus enhancement in MRI existed simultaneity with morning stiffness or and RF positive.

结论MRI血管翳强化与晨僵或类风湿因子阳性同时存在时，对于诊断早期类风湿关节炎具有较大的价值。

Objective: RA is an autoimmune chronic systemic disease, characterized by inflammation, self-immune and the hyperplastic synovial pannus.

目的：类风湿关节炎(rheumatoid arthritis，RA)是一种慢性系统性疾病，其主要病理改变是滑膜炎和血管翳形成及其相关的血清组织中多种细胞因子、抗原抗体和粘附分子等的变化，而细胞因子是RA炎症和损伤的重要介质，对RA患者外周血及滑液中细胞因子改变已有大量研究，已证明多种细胞因子参与RA的病变过程。

Results Extensive and diffuse synovial hyperplasia can be seen in patients with RA;synovial pannus formation can be seen in 25 cases.

结果RA组病人均可见广泛、弥漫的滑膜增生，其中25例病人可见滑膜血管翳形成，而OA组仅7例病人可见轻度滑膜增厚，未见滑膜血管翳形成者(X2=55.78P.005)；RA组关节软骨及软骨下骨改变较严重且弥漫，而OA组软骨退变则较局限，且以关节摩擦大的部位受损为著，其软骨下骨改变较为局限，常常见于IV软骨退变；关节腔积液、半月板及韧带改变，在OA组与RA组之间无差异。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

Res ults:Before IST colonies of CFU-F from only 5 patients were normal,and the colo nies of CFU-F in decreased severely or even absent for the rest;the response ra te of AA patients with CFU-F formation was higher than that of those without CF U-F Formation but not significantly;after IST colonies of CFU-F in creased in significantly from those patients achiveve complete remission and parial remissi on Also they no significant as compared with nonresponsive patients.

结果：IST前仅5例患者CFU-F数量正常，余75例患者CFU-F生长严重缺陷或无生长；有CFU-F生长者疗效优于无CFU-F生长者，但差异无显著性(P＞0.05)。IST后获基本治愈者骨髓CFU-F数量增加最为显著(P＜0.01 )，缓解者及明显进步者CFU-F数量亦增加，但差异不显著(P＞0.05)。

According to the rudiment epidemiological investigation in our country. The ratio of male to female is 1:3. RA regardless of for traditional Chinese medicine or Western medicine, is still a kind of difficult treat disease. Major is the cause of this disease with pathologyical mechanism lack all-sidely thorough understanding, and lack peculiarness laboratory index in the early stage of disease, so early diagnosis is very difficult.

我国经过初步流行病学调查，RA发病率为0.3～0.5%，男女发病比例约为1：3，西医对本病病因和发病机制认识尚欠清楚，缺乏具有针对性的特效药物；虽然据临床报道中医药对RA具有良好的治疗效果，但由于RA的中医证候分类繁多，目前尚无统一证候分类标准，临床疗效观察缺乏可重复性，严重制约了中医对RA研究的深入开展。

There is a variety of Japanese scales but the representative one is the scale that is called the pentatonic and it consists of the five notes,"do re mi so ra".

日本格调的音乐种类很多，但最具代表性的还是五音制，它包括五个主音&1，2，3，5，6&。

RESULTS: Peripheral neuropathy or purpura/petechiae, or both, were the most important clinical features to discriminate patients with RA with and without histologically proven RV.

结果：外周神经病或紫癜/紫斑是区分 RA 患者有无组织学证实的血管炎最重要的临床特征。

Smoking cigarettes adds to the Computer Desk Computer manufacturer computer mouse Computer Computerized collar knitter machine Conduit Bodies construction board Container Bag Control Arm Cooking Thermometer general levels of air pollution as well as damaging our health.

吸烟不仅对健康有害，而且增加空气污染程度。香烟雾含有多种有害物质：不仅有致癌化学物质、有某种能阻止氧气进入血液的气体，还有引起血压增高、心速加快的被称为尼古丁的物质。

He is one of my favorite actors.

他是我最喜欢的男演员之一。