钩吻碱

基本解释 (translations)

gelsemine

与钩吻碱相关的网络例句 [注：此内容来源于网络，仅供参考]

Objective To identify the structure of the alkaloid extract of Gelsemium from east Guangdong province of China.

目的研究粤东产钩吻生物总碱提取物的结构。

The results show:gelsemium total alkaloids injected into vein 4 mg per weight inhibit respiratory remarkably,slow heart rate and drop blood pressure .

结果表明：每公斤体重注射4.0mg以上的钩吻总碱能抑制家兔的呼吸，使家兔心率减慢、血压降低。

Gelsemium total alkaloids ; respiration ; heart rate ; blood pressure

钩吻总碱；呼吸；心率；血压

This paper aims at the study of the toxic mechanism of gelsemium total alkaloids ,i.e. their impacts on respiration,heart rate and blood pressure by 5 different concentrations(0.5,1.0,2.0,4.0,8.0 mg/kg).

为有效合理地利用钩吻，以家兔作为研究对象，每公斤体重分别静脉注射0.5，1.0，2.0，4.0，8.0mg的钩吻总碱，研究钩吻总碱对家兔的呼吸、心率和血压的影响，综合分析其毒理作用。

Gelsemium total alkaloids improved some blood and immune function of mice when it less than 0.30mg/kg body weight, but more than 1.5mg/kg body weight, the gelsemium total alkaloids can reduced some blood and immune function of mice; below the dose of 3%, GEB"s power can improve some blood and immune function of broilers, but GEB"s power can reduce some blood and immune function of broilers above the dose of 6%.

结论是：钩吻对小鼠和肉鸡的血液学及免疫功能的影响均存在着剂量差别，钩吻总碱稀释液在0.30mg／kg剂量以下，能够提高小鼠的某些血液指标与免疫功能(p＜0.05)，而在1.5mg／kg以上，则降低小鼠的某些血液指标与免疫功能(p＜0.05)；3％以下的钩吻干粉能够提高肉鸡的某些血液指标与免疫功能，而6％以上的钩吻干粉则降低某些血液指标与免疫功能。

The results showed as follows: 1 Extraction of gelsemium total alkaloids. Total alkaloids were extracted with 95 per cent ethanol. The extract rate was 0.519 per cent and the extract purity were 88.02 per cent and 87.38 per cent; Total alkaloids were extracted with chloroform .The extract rate was 0.416 per cent and the extract purity were 89.02 per cent and 94.52 per cent. 2 Isolation of gelsemium total alkaloids with TLC. Total alkaloids contained five or more alkaloids. The optimal developing agent was chloroform :methanol :ethyl acetate(9:l:0.3),the optimal eluent was methylene chloride:methanol(92:8). 3 Isolation of total alkaloids with column chromatography. Alkaloid A and alkaloid B were obtained, alkaloid B was identified as koumine.

研究结果如下：1、钩吻总碱的提取：用95％的乙醇提取钩吻生物碱提取率为0.519％，其提取物纯度为88.02％、87.35％；用氯仿提取钩吻生物碱提取率为0.416％，其提取物纯度为89.02％、94.52％。2、钩吻总碱的薄层层析分离：总碱中含有5种或5种已上的生物碱；氯仿：甲醇：乙酸乙酯(9：1：0.3)是最佳薄层层析的展开剂；二氯甲烷：甲醇(92：8)是柱层析的最佳洗脱剂。3、钩吻总碱的柱层析分离：共得到两种钩吻生物碱单体成分碱A和碱B，碱B为钩吻素子，碱A可能是钩吻素甲。4、钩吻总碱的急性毒性试验：钩吻总碱小鼠腹腔注射的半数致死量LD_(50是：7.38mg／kg，95％的可信限范围为：6.67mg／kg～7.94mg／kg。

We demonstrated the effect of the gelsemium total alkaloids of on blood and immune function of three different doses (0.15mg/kg,0.30mg/kg,1.5mg/kg) on mice and dieted with three GEB powers contents(1.5%,3%,6%) on chicken . The results showed as follow:1.The gelsemium total alkaloids of 0.15mg/kg,0.30mg/kg doses increased RBQHB, percentage of ANAE+ lymphocytes, phagocyty of peritoneal macrophage of mice.

本研究探讨了不同剂量(0.15mg／kg、0.30mg／kg、1.5mg／kg)的钩吻总碱稀释液对小鼠的血液学与免疫功能的影响，以及不同日粮添加水平(1.5％、3％、6％)的钩吻干粉对肉鸡血液学与免疫功能的影响，结果表明： 1、灌胃0.15mg／kg、0.30mg／kg剂量的钩吻液，能够提高小鼠红细胞数、血红蛋白含量、外周血ANAE~+淋巴细胞数、腹腔巨噬细胞吞噬指数及吞噬百分率。

Alkaloid A might be gelsemine. 4 Actue toxic test of total gelsemium on mice. Its intraperitoneal LDsotmedian lethel value of total gelsemium was 7.38mg/kg(the confident limit on 95 per cent level was 6.67mg/kg ~ 7.94mg/kg).Main clinical symptoms of acute toxified mice were reducing activities, crouching, depression on low dosage (5mg/kg).

小鼠急性中毒的主要临床症状是：在低剂量(〈5mg／kg)作用下呈现活动减少、静伏、精神沉郁；在中高剂量(〉5mg╱kg)作用下呈现为呼吸困难、惊厥、阵发性痉挛甚至死亡。5、钩吻总碱的亚慢性毒性试验：生理盐水对照组和各钩吻总碱处理组1／50LD_

The study indicated that Ge had distinct analgesic effect.2. Irritation action of rats stimulated by haemostat inhibited and the energy metabolism of mice decreased after ip Ge total alkaloids.

钩吻总碱能抑制大白鼠由止血钳刺激所致的激怒反应，降低小白鼠机体的能量代谢，并且能协同闽下剂量的水合氯醛对小白鼠的催眠作用。

There were no pathological damage of total alkaloid on mice by macroscopical and microscopical examining.

大体剖检及光镜镜检显示钩吻总碱对小鼠不会造成明显的病理损伤。

与钩吻碱相关的网络解释 [注：此内容来源于网络，仅供参考]

gelose：琼脂

gelometry 凝胶强度测定法 | gelose 琼脂 | gelsemine 钩吻碱甲

semolina：粗粒小麦粉

semlsulcus /半沟/ | semolina /粗粒小麦粉/ | sempervirine /常绿钩吻碱/

Gelsemine：钩吻碱

[化学成份]钩吻的主要成分是生物碱,由其根中曾分离出7种单一的生物碱:钩吻碱子(koumine),钩吻碱丑(kouminine)即是钩吻碱(gelsemine),钩吻碱寅(kouminicine),钩吻碱卯(kouminidine),钩吻碱丙即是常绿钩吻碱(sempervirine),

Gelsemine：钩吻碱甲

gelose 琼脂 | gelsemine 钩吻碱甲 | gelseminic acid 钩吻酸

Gelsemine：钩吻碱 钩吻素甲

高三尖杉酯碱 Homoharringtonine | 钩吻碱 钩吻素甲 Gelsemine | 枸橘苷 Poncirin

Gelsemine hydrochloride：盐酸钩吻碱

Gardenin A 栀子宁 | Gelsemine hydrochloride 盐酸钩吻碱 | Gelsemine 钩吻碱

gelseminic acid：钩吻酸

gelsemine 钩吻碱甲 | gelseminic acid 钩吻酸 | gene 基因