- 更多 网络例句 与Quinazoline相关的网络例句 [注：此内容来源于网络，仅供参考]
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Synthesis of target compounds namely: to vanillic acid as the starting material with methanol under reflux conditions for 4 - hydroxy -3 - p-methyl, then ether, and nitration, reduction, cyclization reaction 6 - methoxy -7 - benzyloxy-quinazoline -4 - one, and then by the chloride in place of aniline, benzyloxy-off, such as etherification reaction of the target compounds; target compounds with the second and third occurrence of substitution reactions of amines by the TM1, that is, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(N, N-diethyl amino) oxy c] quinazoline; with ether occurred Ornidazole reaction of TM2, namely, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(2 - methyl -5 - nitroimidazole) C oxy] quinazoline.
本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。
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Methods: In this paper, a quinazoline purine analogues for the parent nucleus, respectively, and four of its seven introduced to replace the structure of diverse and flexible side-chain amino-benzene, design a series of 4 - to replace the aniline-based -6 - methoxy --7 -(2 - hydroxy replace C oxy) quinazoline compounds.
目的：通过各种化学合成方法完成目标化合物4--6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉的合成并对目标化合物进行结构修饰，以期获得高活性的表皮生长因子受体酪氨酸激酶抑制剂。
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Two representative compounds have been determined by X-ray crystallography. The best ratio of reactants, the adequate reaction temperature and solvent have been found by contrast experiments.4. The better photoreaction conditions and irridation times have been confirmed through the different photoreaction results. It is the first time that fifty quinazoline derivatives with biological activity and four photooxidation products with urea functional groups have been obtained by photochemistry method. Two representative compounds, quinazoline derivatives and photooxidation products, have been determined by X-ray crystallography, respectively.
通过实验对比我们找到了较佳的反应物的投料比、反应温度和反应所用的溶剂。4、根据不同条件下的光反应结果，确定了硫脲衍生物的相对较好的光反应条件和光照时间，首次利用光化学手段成功得到50个具有生物活性的喹唑啉衍生物和4个具有脲基官能团的光氧化的产物，测定了两个具有代表性的喹唑啉和光氧化的产物的晶体结构。
- 更多网络解释 与Quinazoline相关的网络解释 [注：此内容来源于网络，仅供参考]
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quinazoline：喹唑啉
易瑞沙是喹唑啉(quinazoline)类表皮生长因子受体(EG-FR)酪氨酸激酶抑制剂,通过竞争性结合ATP来抑制EGFR细胞内的酪氨酸激酶域的自磷酸化作用,阻断了下游信号的传递,从而达到抑制肿瘤血管生成、细胞增殖、侵袭以及转移,促进细胞凋亡的治疗作用,
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quinazoline：喹唑啉;间二氮杂萘
quinalizarin 醌茜素 | quinazoline 喹唑啉;间二氮杂萘 | quinhydrone 醌氢醌;对苯醌合对苯二酚
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quinazoline alkaloid：吡咯生物碱
吡啶生物碱 pyrrolizidine alkaloid | 吡咯生物碱 quinazoline alkaloid | 吡咯联啶生物碱 quinoline alkaloid