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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Thus, Allison need not hold any opinion regarding her daughter's having learning difficulties for her false belief that she is not experiencing difficulties to count as self-deception, since it is her regarding evidence in a motivationally biased way in the face of evidence to the contrary, not her recognition of this evidence, that makes her belief self-deceptive.

因此Allision不需要对有关自己女儿学习障碍方面有任何立场就可以将她对女儿没有障碍的虚假信念算作自我欺骗,因为造成她的信念成为了自我欺骗的是在相反的证据面前用动力引起下具有偏见的一个方式对待证据,即:不承认她的证据。

5.12 wenchuan great earth quake put us down into deep mental crisis.three emotional-behavioral disorders which go together with post-disaste mental crisis,self-closure reactivity,intropunitive reactivity and self-abandon reactivity,always make negative influences upon our mental health,mental rehibilitation and mental development.based on the analysis on the features and reasons of these disorders,some effective strategies and technics for mental regulation of these post-disaster emotional-behavioral disorders are offered.the authors believe that post-disaster learning and self-helping must be the chance for people to gain both mental growing and wisdom increasing.

5.12汶川特大地震灾难使人民经受了巨大精神打击,陷人民于深深的心理危机之中。灾后心理危机中容易伴生的三种情绪与行为反应障碍:自闭、自责、自弃,会威胁着群众的心理健康,会阻挡人们的心理重建和成长。本文在对自闭反应倾向、自责反应倾向和自我放弃反应倾向进行心理学分析的基础上,介绍了一些灾后情绪与行为反应障碍的自我调适策略与技术。作者认为,灾难后的学习与自助,是人心成长、人生智慧增长的契机。

In this thesis, research on alleviation of autotoxicity by planting mixture of Chinese fir and Broadleaf trees and developing undergrowth vegetation were also done. The results showed that Michelia macclurei and Cinnamomum camphora had positive allelopathic effect on the growth of Chinese fir saplings and developing undergrowth vegetation improved soil decline of Chinese fir plantation.

另外,论文还从植物化感作用的角度,对克服杉木人工林连栽障碍的其它生产措施,如营造混交林及人促林下植被的发育生长,进行了研究:提出了与杉木化学生态关系良好的两种伴生树种,并从化感作用角度证明人促林下植被发育有利于克服杉木人工林的连栽障碍。

Objective To use an ischemical reperfusion injury rat model by pulsinelli-4-VO andobserve the changes of the expression of Glu, N-methy-D-asparagic acidreceptor subunits NR_1 and NR_(2B) and ability of learning and memory after procerebrum ischemic reperfusion injury, and approach the pathogenesy of learning andmemory disorder induced by ischemic reperfusion injury, and the intervention ofginsenoside Rg_2 on the learning and memory disorder after procerebrumischemic reperfusion injury.

目的利用pulsinelli四血管法体建立脑缺血/再灌注损伤模型,观察前脑缺血损伤后谷氨酸、N-甲基-D-天门冬氨酸受体亚单位NR_1、NR_(2B)表达的变化及学习记忆的改变,从兴奋性氨基酸的兴奋毒作用尤其是其受体的表达方面探讨脑缺血/再灌注损伤引起的学习记忆功能障碍的发生机制,并观察人参皂苷Rg_2对脑缺血缺氧损伤引起的学习记忆障碍的干预机制。

In allusion to the holdbacks which often come forth in pipe-jacking construction,the practicing experience of many pipe-jacking operators is summed up and some new settling methods are put forward in the text.

针对顶管施工中经常出现的一些障碍,总结了顶管工作者的实践经验,提出了一些新的解决方法,并阐述了障碍的许多预防措施,希望对以后的顶管施工实践有所帮助。

The pumb surface temperature is too high, the oil pressure table index for 0.3, and no oil lubrication "" on: based on the analysis of the causes of that failure is not dumping fuel (due for not getting a loop outflow, cooling and pressure is not enough ESP.).

油泵暗地温度功矮,不雅其油压外洋的指数为0.3,而且不不收油&润滑&障碍阐发与摈斥:根据差这种环境的阐发,觉得障碍的来因仍在于不不收油(变成泵边的油得不到轮回不源不入、加冷且不张力也不敷落矮的本体)。

Disabled children and normal children are basically go to school separately.The children of light hard-of-hearing or language disorders have to enter the Blind and Deaf School because they are turned away by normal school,as a result,they are hard to communicate with children of the same age.

残疾儿童和正常孩子基本上都是分开入学的,一些有着轻度听力障碍或者语言障碍的孩子,也因为一般的学校的拒之门外,而不得不进入盲聋学校学习,他们很难和同龄正常的孩子有一个沟通交流的环境。

The paper finds that Bukharin places emphasis on the idea that equilibrium growth model of dual sectors is the best choice for the attainment of industrialization in underdeveloped countries.

本文认为,布哈林的这种工业化模式有其可供借鉴的方面,如对经济落后国家的二元结构分析以及据此提出的二元经济平衡增长的思路,但是,这种模式在实施中也存在着一些障碍,而布哈林本人未能提出克服障碍的有效措施并进行可行性论证。

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