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ABSTRACT Objective To establish an HPLC method for the determination of azithromycin powder.Method The chromatographic conditions were as followed: C8 column, 0.045 mol/L ammonium phosphate monobasic solution∶acetonitrile (2∶1)(adjusted to pH7.35 with triethylamine) as mobile phase, temperature: 40℃, the flow rate: 1.0 ml/min, detection wavelength: 210nm.

阿奇霉素为氮杂内酯类抗生素,日抗基和《中国药典》2005年版[1]均采用微生物检定法测定其含量,《欧洲药典》4.6版和USP26版中均采用HPLC法,专属性较强,试验周期短,但均使用的是聚合物极性柱,《欧洲药典》柱温为70℃,USP采用电化学检测器,其采用的设备在我国药检部门尚未普及[2]。

Anhui Institute for Drug Control, Hefei 230051ABSTRACT Objective To establish an HPLC method for the determination of azithromycin powder.Method The chromatographic conditions were as followed: C8 column, 0.045 mol/L ammonium phosphate monobasic solution∶acetonitrile (2∶1)(adjusted to pH7.35 with triethylamine) as mobile phase, temperature: 40℃, the flow rate: 1.0 ml/min, detection wavelength: 210nm.

阿奇霉素为氮杂内酯类抗生素,日抗基和《中国药典》2005年版[1]均采用微生物检定法测定其含量,《欧洲药典》4.6版和USP26版中均采用HPLC法,专属性较强,试验周期短,但均使用的是聚合物极性柱,《欧洲药典》柱温为70℃,USP采用电化学检测器,其采用的设备在我国药检部门尚未普及[2]。

Methods 20 female SD rats with russula subnigricans were ramdomly divided into 4 groups as follows, normal group, fed with normal saline, model Ⅰ group, with russula subnigricans, model Ⅱ group, with Lingzhi decoction after modeled by russula subnigricans, and fourth group, with Lingzhi decoction only for comparison.

用SD大鼠20只,随机分为4组,分别为:空白组,采用生理盐水灌胃时照;模型组Ⅰ,采用亚稀褶黑菇毒素灌胃造模;模型组Ⅱ,采用亚稀褶黑菇毒素灌胃造模后,用灵芝煎剂灌胃治疗;灵芝组,采用灵芝煎剂灌胃对照。观察大鼠的存活情况、活动情况、尿颜色、尿量、尿红细胞、尿白细胞、尿蛋白、血液生化、NAG酶以及肾脏病理检查等指标。

The question's semantic comprehension model combines many natural language processing techniques, including Segmentation and Part-Of-Speech Tagging, the confirmation of the question type, the extarction of keywords and extending, the confirmation of the knowledge unit, Through these works, the intention of the user is holded, which greatly helped the last work of this system. The FAQ-based question similarity match model is implemented by sematic sentence similarity computation, which is improved by our system, this model can answer frequently-asked question fastly and concisely.The document warehouse-base automatic answer fetching model fistly deal with the document warehouse beforehand and construct inversed index, then use high efficient information retrieval model to search in the base and return some relevant documents, lastly, we use answer extraction technique to get the answer from these relevant documents and present it to users.

问句理解分析模块采用分词和词性标注、关键词提取及扩展、问句类型类别确定等自然语言理解技术,实现对用户提问意图的准确理解;FAQ 库问句匹配模块主要采用本系统改进的句子相似度计算方法来实现用户问句的解答,该模块主要用于实现用户常问问题的快速、准确解答;学科文档库答案自动获取模块在对学科文档库建立倒排索引的基础上,采用高效的信息检索模型对索引库进行检索,返回与用户查询表达式相似度较高的文档作为候选文档,针对从文档中直接获取答案难度较大这一问题,本系统采用答案抽取技术来实现问题的最终回答。

The mian works are as follows:(1)By coprecipitation technique and coprecipitation- gel technique the nano zirconia powder was produced, factors affecting the properties of nano zirconia powder such as pH and the content of stabilizator are analyzed;(2)By the new pressless sintering process, the nano zirconia ceramic was produced, factors which can affecting the properties of nano zirconia sinter body such as moulding press and the sinter temperature are analyzed;(3)By the microtherm pressless sintering process, the nano copper added functional zirconia ceramic composite was produced, microscopic dimensionality and electric properties of such sinter body and the factors affecting such sinter body are analyzed;(4)By the self-invented "external albumen coating" technique the zirconia powder was successfully coated by carbon in the corresponding sinter body, which can help solve the traditional aggregation problem to some degree;(5)Based on analyze the characteristics in the nano powder sinter process, the "three-ball sinter model" was proposed, for the relationship between the relative density and porosity of sinter body, by mathematical fitting, such model was successfully verified.

本研究比较系统地研究了纳米氧化锆陶瓷的合成与成型机理,特别是讨论了纳米氧化锆陶瓷的稳定性,为防止纳米颗粒在外场作用下的团聚和长大提供了理论基础和实验数据,具体工作有以下几方面:(1)采用共沉淀法和共沉淀-凝胶法制备了纳米氧化锆粉体,并分析了pH值和稳定剂含量对粉体性能的影响;(2)采用新型无压烧结工艺制备了纳米氧化锆陶瓷,并分析了成型压力和烧结温度对烧结体性能的影响;(3)采用低温无压烧结工艺制备出添加纳米铜的功能性纳米氧化锆复合陶瓷,并分析了烧结体的微观尺度和电学性能的变化以及影响因素;(4)通过自创的&鸡蛋清外敷法&在真空镀膜台上对纳米氧化锆粉体进行包敷碳颗粒的表面处理,并采用真空烧结工艺制得相应烧结体,初步开始解决陶瓷烧结过程中团聚长大这一传统难题;(5)通过分析纳米颗粒在制备烧结体过程中的实际特点,提出了&三球烧结数学模型&,通过引入坯体相对密度和孔隙率的相对关系分析并通过自行编写的数学拟合软件,验证了这一数学模型。

There are two defferent design of hardware: optical fiber temperature sensor is used for middle-voltage Metal-clad switchgear, which data is transferred by optical fiber; another one is 1-Wire Digital Thermometer, it is used for lower-voltage Metal-clad switchgear, and the data is transferred by unwired.

硬件方面设计了两种不同的温度传感系统:中压开关柜过热故障监测采用光纤式温度传感器,同时采用光纤传输数据;低压开关柜采用单总线数字式温度传感器,数据采用无线传输。

Adopts the all- air and natural ventilation system for the opening north wall;the floating floor and isolation table to isolate machine vibration,the sounds insulation materials between two walls to insulate noises in the plant;the air conditioning system separately for the audience area and sports area,the fan-coil unit and floor heating system only for the sports area to adapt the use after the Olympic Games,the natural ventil...

针对1层两个比赛厅北墙敞开的特点,采用全空气空调系统、排风从敞开空间自然排出方案;针对空调机房距4个比赛厅仅一墙或一板之隔的特点,空调机隔振采用浮筑楼板加减振台板、隔声采用双墙中间夹隔声材料层的方案;针对奥运会后观众区改作他用、运动区继续作集训使用的特点,观众区和运动区各有一套空调系统,运动区另设风机盘管和地板供暖;针对步枪、手枪射击时产生弹药味的特点,采用吊顶设通风格栅、高窗设电动开启的自然通风方案。

At present, millimeter wave response of K wave band was applied in American BCIS system, the millimeter wave identification was used in French BIFF system, beaconing identification of millimeter wave was applied in British M-TICE system, laser enquiry and response of L wave band was used in Germanic ZEFF system.

目前,美BCIS系统采用K波段毫米波问答,法BIFF系统采用毫米波识别,英M-TICE系统采用毫米波信标识别,德ZEFF系统采用激光询问和L波段应答。

Methods: Totally 2200 patients with varicose vein received surgical treatment in our hospital from July, 2000 to January, 2006. 1802 cases were treated by endovenous laser therapy combined with transilluminated powered phlebectomy.82 cases were treated with radiofrequency endoveous occlusion combined with TIPP,218 cases treated with limited invaginated vein stripping and foam sclerotherapy.

回顾性分析2200例下肢静脉曲张外科治疗的临床资料,其中1802例患者采用激光联合透光直视旋切术,82例患者采用射频联合透光直视旋切术,218例患者采用选择性内翻式大隐静脉剥脱联合硬化剂治疗或透光直视旋切术,其余98例患者分别采用激光、高位结扎、射频处理大隐静脉主干,辅以曲张静脉团的手术切除、激光、电凝、皮下连续缝扎或硬化剂注射方法治疗。

The results show that after quenched and tempered with protective coating,no elements in the protective coating are found to permeate into the matrix,but the martensite laths in welded zone and heat affected zone are refined and the dispersion of carbides in these area is increased,the sizes of the dimples in these fracture are decreased.

通常情况下,D406A钢壳体在热处理中未采用保护气氛,造成调质后壳体表面脱碳严重,使壳体强度降低。为防止或减少调质处理过程脱碳带来的不利影响,可采用保护涂料或保护气氛热处理以及真空热处理等[2],但对于大型工件,采用保护气氛或真空热处理需要大量的设备资金投入;而采用保护涂料投入较少。

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