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酰化产物

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Hepatic sinusoid capillarization plays an important role in occurrence of portal hypertension. The fenestra of endothelial cells in hepatic sinusoid reduces and the diameter of fenestra decreases. The formation of basement membrane impaires the substance exchange between blood and hepatic cells,which results in oxygen deficiency, metabolic product accumulation and cell necrosis.

肝窦毛细血管化在硫代乙酰胺诱导的肝硬化门脉高压发生中起重要作用,肝窦内皮细胞窗孔减少并减小,内皮细胞下基底膜形成使肝细胞与外界物质交换减少,导致细胞缺氧、代谢产物聚集,肝细胞坏死,最终导致门脉高压的发生。

Methods In situ method of terminal deoxytransferade-mediated dUTP-biotin nick and labelling staining was used to identify programmed cell death in 20 KAs. These cases also were examined with immunohistochemical technique for the expression of two protooncogenes, bcl-2 and bax, recently recognized to be involved in apoptosis.

用末端脱氧核苷酰转移酶介导的d-UTP生物素缺口末端标记技术,原位检测20例角化棘皮瘤中凋亡细胞;应用免疫组织化学技术检测皮损部位bax和bcl-2基因产物的表达。

Benzyloxy benzoyldimethylsulfoxide was prepared by the reaction of ethyl 4-benzyloxybenzoate and dimethyl sulfoxide in the presence of sodium hydride, followed by Pummerer reaction with concentrated hydrochloric acid to afford eo-hydroxy-co-thio-methyl-(4/-benzyloxy) acetophenone, which reacted with urea, thiosemicarbazide, semicarbazide hydrochloride and o-phenylenediamine to give imidazolidine-2,4-dione, l,2,4-triazine-3- one and quinoxaline derivatives, respectively.

本文用4-苄氧基苯甲酸乙酯和二甲亚砜为原料,在氢化钠存在下反应,合成了(4′-苄氧基)-苯甲酰基-二甲亚砜。研究了该亚砜在浓盐酸的存在下发生的Pummerer重排反应,用重排产物ω-羟基-ω-甲硫基-(4′-苄氧基)-苯乙酮分别与尿素、氨基脲、氨基硫脲和邻苯二胺反应合成了2,4-咪唑啉-二酮、1,2,4-三嗪-3-酮、喹喔啉等含氮杂环化合物。

The auxiliary can be recovered in high yield (81%) only by filtering and recrystallization. Besides, some other aldehydes have been chosen to test the enantioselectivity of N,N\'-dibenzyl tartamide, in comparison with two other allylaborates reagents developed previously by Roush and Brown, respectively. The results show that %e.e. of homoallylic alcohol is superior to that of the former, and approaches the Brown reagent.

产物经S_N2反应得瑞格列萘中间体-甲基烯丙基-2-氯苯基-叠氮甲烷(17);同时,将筛选出的新型手性配体N-苄基酒石酸二酰胺用于其他几种醛(正丁醛,异戊醛和环己醛)的不对称烯丙基化反应,并与广泛应用的Roush配体(22)和Brown配体(27)相比较,发现其立体选择性优于Roush配体,并接近Brown配体,但明显具有可回收利用的优势。

When SiO〓-NH〓-Rh-Co complex was used to catalyze the hydroformylation of methyl methacrylate, an optimal conversion of 93.4% and optimal selectivity of 84.4% for the normal aldehyde were both obtained at Rh/Co ratio of 2/1, which were both higher than that catalyzed by SiO〓-SiNH〓-Rh and SiO〓-Si-NH〓-Co momometallic catalysts. Clearly a synergistic action between Rh and Co atoms presented in the complex.

我们以SiO〓-Si-NH〓-Rh-Co催化甲基丙烯酸甲酯的醛化反应,当催化剂中Rh/Co比为2/1时,催化活性最高,可达93.4%,对正构产物β-甲酰异丁酸酯的选择性达到84.4%,都高于单金属催化剂,表明了金属间存在相互作用。

To investigate the expression, location and function, long distance PCR was used to expand the targets containing open reading frame. The expressive vectors of prokaryotic and eukaryotic cells were constructed after product purification and connecting with vectors. The prokayotic vectors were induced to express the protein by IPTG and the protein was seen by denaturalization PAG electrophoresis and dyeing. The eukayotic expressive vectors were transfected into culture cells and the protein was found in the nulceolus under the observation of the confocal microscope. The transfected cells were chosen by the geneticin (G418). The cell cyele was examined by flow cytometer and the cell numbers were reduced obviously in the stage of G〓-G〓 and G〓-M, but increased distinguishably in the S stage.

为研究磷酸化应激诱导蛋白的表达、定位和功能,采用了长距离聚合酶链反应扩增含有开放阅读框架的靶片段,经产物纯化、与载体连接,分别构建了STIP1基因的原核表达载体和真核表达载体;IPTG诱导原核表达载体,变性聚丙酰胺凝胶电泳与染色后,可见相应大小的蛋白质表达;STIP1基因的真核表达载体转染细胞系后,共聚焦显微镜下观察STIP1蛋白主要分布于细胞核内;用药物筛选STIP1基因转染的细胞后,流式细胞仪检测细胞周期,可见G〓-G〓期和G〓-M期的细胞明显降低,S期细胞明显增多。

However,they are generally insoluble and infusible in their fully imidized form,which would lead to processing difficulties;and this process of polyintermediate has several inherent problems such as emission of volatile byproducts(e.g.,H_2O)and storage instability etc.

然而,完全亚胺化的芳香族聚酰亚胺通常不溶不熔,难于加工,而采用聚酰胺酸中间体加工时,又存在储存稳定性差,加工过程中会产生可挥发小分子副产物(如;H_2O)等问题。

The production of by-products caused the productivity of levulinic acid lower than theoretical one. Based on the study of the degradation of glucose and the formation of 5-hydromethylfurfural and levulinic acid, a kinetic model was proposed, in which, the process was described by a series first-order reactions with parallel by-reaction.

在葡萄糖降解的初始阶段还存在着异构化和可逆反应,降解过程中形成了羟甲基糠醛、腐殖质、乙酰丙酸、甲酸和其它中间产物。

The products include antioxidants,blowing agents,organic solvents, intermediates for pesticides,drugs and dyestuffs,perfumes,water glass,silicates,molybdenum compounds,graphite series,activated carbon,plasticizers,flame retardant,heat stabilizers,food additives and chemical reagents,etc.

注册商标有&鹿牌&合成樟脑,&桃浦&牌合成樟脑副产物和其他化工产品,&金牛&牌抗氧剂,发泡剂,水合肼,二甲基乙酰胺,二甲基乙醇胺,&海球&牌硅胶系列,&飞铃&牌磷氯,双乙烯酮衍生物,磷酸酯,乙烯利等,&泉字&牌,&水晶&牌各类泡化碱系列,&上胶&牌钼类化合物,石墨类产品系列。

The complexes areneutral as shown by values of molar conductivity in aqueous solution, namely,〓 The crystal structure determinations show that, in complexes, metal ions werecoordinated by four nitrogen atoms and form slightly distorted square planar configuration,relationship between fluorene ring plane and coordination plane is similar to those betweenpeptide planes of β-folding in proteins. The complex molecules linked by hydrogen bonds formone dimension chain or two dimension network structure.

摩尔电导测定表明他们都是二氧四胺中酰胺氮去质子化后形成的产物。X-射线衍射晶体结构测定表明〓的铜、镍配合物的配位多面体都是稍微畸变的平面正方形,配合物分子中芴基平面与配位平面的关系类似于蛋白质β-折叠结构中肽平面之间的关系,配合物分子之间通过氢键连接成一维链状或二维网状结构。

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