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The present invention relates to a process for rapid solution synthesis of a peptide, the process comprising repetitive cycles of steps-: a coupling step, using an excess of an activated carboxylic component to acylate an amino component, a quenching step in which a scavenger is used to remove residual activated carboxylic functions, wherein the scavenger may also be used for deprotection of the growing peptide, one or more aqueous extractions and optionally, a separate deprotection step, followed by one or more aqueous extractions, characterised in that the process comprises at least one step, referred to as step, in which an amine or a thiol comprising a free anion or a latent anion is used as a scavenger of residual activated carboxylic functions.

本发明涉及快速溶液合成肽的方法,该方法包括步骤-的重复循环:偶联步骤,使用过量的活化羧基成分酰化氨基成分,淬灭步骤,在该步骤中使用清除剂除去残余的活化羧基官能团,其中该清除剂还可以用于使生长中的肽去保护,一或多个水抽提和任选地,独立的去保护步骤,之后进行一或多次水抽提,其特征在于该方法包括至少一个步骤,称作步骤,在该步骤中包含自由阴离子或潜阴离子的胺或硫醇用作残余活化羧基官能团的清除剂。

Other causes include loss of antifoam additives, suction leaks, poor reservoir design, using the wrong viscosity or using too much antifoam additive.

其他原因包括抗泡沫添加剂丧失,吸入泄露,蹩脚的油箱设计,粘度不对,或防泡沫添加剂使用过量。

Dishwashers use an excessive amount of water and energy, and rob the family of one of the rare moments in modern life when they can work and talk together. Instead of using a dryer, that shortens the life of your clothing, line dry your clothes - or if weather and/or circumstances don't allow, use a clotheshorse to dry indoors.

洗碗机耗费过量的水电,而且剥夺现代家庭成员,难得一起工作和聊天的片刻,不要使用烘干机,这样会缩短衣服穿用年限,直接把衣服挂在户外晾干--若天气情况不允许,使用晒衣架在室内晾干。

Its emission density is measured with the five-gas analysis apparatus.It is found find out coefficient of excess air and its characteristics with loads changing,ignition timing and ...

得出了使用五气分析仪能定量地对小型通用汽油机进行排放试验研究和生产质量控制,过量空气系数及随负荷变化的过量空气系数特性、点火正时及标定转速不同是影响小型通用汽油机整机排放的主要因素的结论,给出了188F通用汽油机达到美国和欧盟现阶段排放限值同时能优化汽油机动力性、经济性和工作稳定性等综合性能的措施。

Results 86.8% of IDUs could not insist on using condoms, 25.7% had multiple sexual partners, 49.0% had IDUs as sexual partners, 70.7% didn't know whether comate had infected HIV. High-risk sexual behavior was relative with these factors: starting drug taking at younger age, more frequencies of excessive injection, denial attitude to condom using, and using dirty injection equipment with others. Unmarried status, willingness to use condoms and voluntary HIV testing related with secure sexual behaviors.

结果 IDUs中86.8%不能坚持使用安全套,25.7%有多个性伙伴,49.0%有IDUs性伙伴,70.7%不了解对方HIV感染情况;首次吸毒年龄小、注射过量次数多、对安全套的否定态度、共用不洁注射工具与不安全性行为有关,而未婚、继续使用安全套意愿、自愿HIV检测等与安全性行为有关。

In order to minimize the pollution of the environment with waste acids and/or waste acidic salt solution, following measures were taken:(1) Instead of using excess sulfuric acid, sulfonation reaction was carried out in the presence of excess toluene and the water produced during the sulphonation was removed by azeotropic distillation.

在CLT酸生产中,为了使废酸和酸性废盐水对环境的污染减少到最低程度,采取了如下的措施:(1)与使用过量硫酸相反,磺化反应是在过量甲苯的存在下进行,同时用共沸蒸馏方法移出了磺化过程中产生的水。

Illegal drugs are of variable quality and purity, and poisonings and overdoses are common and often fatal.

非法的毒品有著不同的质量和纯度,毒化或者过量使用是常犯的并且是致命性的错误。

Most of the patients (93%) also reported severe headache-related disability, and 65% were overusing acute pain medications.

多数患者(93%)同时报告严重头痛相关失能,并且65%的患者中存在急性镇痛药物过量使用

However,most disinfectants are organic compounds which might be hazardous to the environment and human when used excessively.

然而,大部分杀菌剂都是化学合成制剂,过量使用此类产品可能会给环境和人类自身健康带来危害。

Essive and compulsive use of drugs to the point of damaging one's health.

强迫性过量使用毒品,以致损害身体。

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