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The degradating and redistributing of ECM were migration of VSMC and vascular remodeling through inhibiting the production of PDGF-BB and the activation of MMPs so to prevent the vascular stenosis.⑤Orthotopic hybridism in situ: The expression of MMP-3 increased after operation, the tendency and intensity were parallel to the expression of NF-κB. Tongxinluo could decrease the expression of MMP-3 and NF-κB. The study showed that the producting and activating of MMP-3 were modulated by NF-κB. The inhibition to the producting and activating of MMp-3 of Tongxinluo was mediated by inhibiting the activating of NF-κB. Conclusion ①The rabbit vascular stenosis model could be established successfully by plain balloon damage, the operation process was easy, economical and practical.

①单纯球囊损伤可成功建立典型家兔血管狭窄模型,操作方法简单,经济实用;②以VSMC增殖、迁移为主的内膜增厚以及以ECM降解、合成与再分布所致的血管重构是导致受损血管狭窄的根本原因;③通心络能明显抑制VSMC的增殖、迁移和ECM降解、合成,阻止血管内膜增生和血管重构,防止受损血管狭窄;该作用可能与其减少和阻止PDGF-BB的产生和活性,以及抑制MMPs的表达和恢复MMPs/TIMPs平衡有关;④通心络能显著抑制球囊损伤后血管内膜增生和血管重构,可能与其保护血管内皮,改善内皮功能,增加血清NO含量有关;⑤通心络抑制内膜增生和血管重构,减轻受损血管狭窄,还可能是通过抑制NF-κB的活化途径而起作用的。

Prior administration of "Styrax Pill for Coronary Disease" proper (6 components viz., styrax liquidus, Borneolum, Lignum santali, Aristolochia, Olibanum and Cinnabaris) or the mixture of Styrax liquidus, Borneolum, Lignum Santali and Olibanum to mice prolonged the survival time of the animals subjected to low pressure hypoxia. Styrax liquidus and Borneolum administered separately showed the same effect, whereas none of the other four components showed significant protection.

用小鼠耐缺氧试验和麻醉狗冠状窦血流量及心脏动-静脉血氧差(MA-VO_2)的实验研究冠心苏合丸及其成分的作用,发现:(1)冠心苏合丸能延长小鼠耐缺氧的时间;(2)冠心苏合丸能使心肌梗塞狗的CSF回升,减少心率和MA-VO_2,对非心肌梗塞狗不能提高CSF但亦能减少心率和MA-VO_2;(3)在本实验条件下,苏合香脂和冰片似为冠心苏合丸中起作用的两个成分,其余成分如檀香、青木香、乳香或其油均未能证实其效果。

Opuntia Milpa Alta prolonged the exhausted swimming time of mice notably, strengthened the LDH activity, accelerated the removing of the LA and BUN, strengthened the SOD activity of liver and skeletal muscle, accelerated the removing of the MDA content of liver and skeletal muscle, demonstrated positive Anti-Movement-Fatigue function. We inferred one of Anti-Movement-Fatigue mechanism was that Opuntia Milpa Alta could increase the exercise ability and load adaptive capacity of the organism and accelerate the removing of metabolites.

米邦塔仙人掌能显著延长运动组小鼠力竭游泳时间,增强运动小鼠的乳酸脱氢酶活性,加快血清乳酸和尿素氮的清除,增强运动小鼠肝脏、骨骼肌超氧化物歧化酶活性,加快肝脏、骨骼肌丙二醛的清除,显示出了积极的抗运动性疲劳作用,并推测其抗运动性疲劳的机制之一是通过增强机体运动能力和负荷适应能力,加快代谢产物的清除起作用

Without Nanog, pluripotency does not develop, and the inner cell mass is trapped in a pre-pluripotent, indeterminate state that is ultimately nonviable.

研究人员解释说,"Nanog"并不是单独起作用,它更像一个"乐队指挥",协调着一系列基因和蛋白质,让它们在各自正确的位置上发挥作用,最终为细胞带来神奇的全能性。

A difference not only now, M. says, but also in the long term.

M。说不只是现在其作用,而且能长远起作用

When soft language Wen Yu3 already no longer function, be hair Dia to act in pettish to bump icy cold of the rock play back, this is this to recruit to produce result of time arrival.

当软语温语已经不再起作用,当发嗲撒娇撞上冰冷的石头弹了回来,这就是此招发挥作用的时刻到来了。

Background— Statins exert pleiotropic effects on the cardiovascular system, in part through an increase in nitric oxide bioavailability.

研究背景:他汀类药物在心血管系统有多重作用,其中部分是通过增加NO的生物利用度而起作用

Education light with an open mouth is nothing doing, the simple preachment function of mouth is very limited, if really complete function of words, that society how still have so many criminals?

教育光凭一张嘴是不行的,嘴巴的简单说教作用是很有限的,如果真的完全起作用的话,那社会怎么还有那么多罪犯?

But there is another force at work here, too. If we see a pushbutton in an unlikely place

但是这里还有另一种力量在起作用,如果在没有把握的地方,如汽车的引擎盖上看到按钮,我们想像不出它有什么作用,但我们知道它是可以用手指按的对象。

But there is another force at work here, too. If we see a pushbutton in an unlikely place such as the hood of a car, we cannot imagine what its purpose is, but we do recognize it as a finger-pushable object.

但是这里还有另一种力量在起作用,如果在没有把握的地方,如汽车的引擎盖上看到按钮,我们想像不出它有什么作用,但我们知道它是可以用手指按的对象。

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Objective To investigate the effects of interleukin-1 β converting enzyme gene on the biologic characteristics of ovarian cancer cells.

目的 探讨白细胞介素-1 β转换酶的表达,对卵巢癌细胞生物学特性的影响。

Campylobacter: This illness is the most commonly identified cause of diarrheal illness in the world.

弯曲:这种病是最常见的原因查明腹泻病,在世界上。

Gangs fill the daily lives of many of our poorest and most vulnerable citizens with a terror that the court does not give sufficient consideration, often relegating them to the status of prisoners in their own homes.

法院没有充分的考虑到黑社会的猖獗所带来的恐怖,这使得我们最穷、最可怜的市民每天生活在他们的阴影当中,成为在家的囚犯。