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Compared with classical cytotoxic T lymphocytes , NK cells are superior in the following aspects: NK cells are among the first cell types to be activated after intracellular pathogen stimuli, the activity of NK cells peaked between 1 to 3 days, retained during the first 7-10 days, and the T cells response emerged only after 7 days when the NK cell responses begin to decline; though comprising of only 10%-15% of peripheral lymphocytes, NK cells mobilize most of the cell populations in a strong and high level response to different invasions, and act as key factors at early defense before a specific immune response could mount, while only certain clones were involved in T cell response; NK cells kill virus-infected or malignant transformed cells without pre-sensitization and without restriction by major histocompatibility antigen, which is usually a mechanism of immune escape to T cell recognition by virus-infected or tumor cells, thus NK cell in complementary with T cells play crucial roles in tumor and virus eradication.

NK细胞以其强大的细胞毒活性为特征,与细胞毒性T细胞相比,NK细胞具有如下特点:NK细胞虽然只占外周血淋巴细胞的10-15%,但是对刺激性因素产生应答的过程十分迅速,一次可以调动大多数细胞共同参与,而不是几个克隆的活化,免疫应答的强度高;病毒感染或恶性转化细胞的一个主要特征是细胞表达的MHCⅠ类分子下降或消失,并借助这一机制逃避特异性T细胞应答的识别,NK细胞介导的杀伤活性无需抗原刺激,不受MHCⅠ分子表达的限制,从而与T细胞应答互为补充发挥免疫防御的功能;NK细胞的免疫活性可以被多种细胞因子上调,其中IFNα,IL-2,IL-12,IL-15和IL-18具备更强的作用;NK细胞具有强大的细胞因子分泌功能,对于启动T细胞特异性应答必不可少。

To cherish peace and friendly intercourse with all nations having correspondent dispositions; to maintain sincere neutrality toward belligerent nations; to prefer in all cases amicable discussion and reasonable accommodation of differences to a decision of them by an appeal to arms; to exclude foreign intrigues and foreign partialities, so degrading to all countries and so baneful to free ones; to foster a spirit of independence too just to invade the rights of others, too proud to surrender our own, too liberal to indulge unworthy prejudices ourselves and too elevated not to look down upon them in others; to hold the union of the States as the basis of their peace and happiness; to support the Constitution, which is the cement of the Union, as well in its limitations as in its authorities; to respect the rights and authorities reserved to the States and to the people as equally incorporated with and essential to the success of the general system; to avoid the slightest interference with the right of conscience or the functions of religion, so wisely exempted from civil jurisdiction; to preserve in their full energy the other salutary provisions in behalf of private and personal rights, and of the freedom of the press; to observe economy in public expenditures; to liberate the public resources by an honorable discharge of the public debts; to keep within the requisite limits a standing military force, always remembering that an armed and trained militia is the firmest bulwark of republics——that without standing armies their liberty can never be in danger, nor with large ones safe; to promote by authorized means improvements friendly to agriculture, to manufactures, and to external as well as internal commerce; to favor in like manner the advancement of science and the diffusion of information as the best aliment to true liberty; to carry on the benevolent plans which have been so meritoriously applied to the conversion of our aboriginal neighbors from the degradation and wretchedness of savage life to a participation of the improvements of which the human mind and manners are susceptible in a civilized state——as far as sentiments and intentions such as these can aid the fulfillment of my duty, they will be a resource which can not fail me.

我认为应珍视与所有志同道合的国家的和平相处和友好往来;对所有交战国则保持真诚的中立;在任何情况下,对分歧都应采取友善的协商和理智的调停,而不能诉诸武力加以解决;来自国外的种种阴谋诡计和对外国的偏袒不公,对任何国家来说都是卑下可鄙的,对自由国家则更是危害非浅,故应予以摒弃;要培育一种独立的精神,这种精神非常公正而不会侵犯他人的权利,非常自尊而不会放弃我们自己的权利,非常开明而不耽溺于我们自己毫无价值的偏见,非常高尚而必然鄙弃他人抱有的偏见;要把各州的团结作为我们和平与幸福的基础;要拥护作为联邦凝聚剂的宪法,不仅维护它的权威,而且遵从它的限制;要尊重保留给各州和保留给人民的各项权利和权力,这对整个制度的成功同样休戚相关和不可或缺;信仰的权利和总价的功能已然明智地排除在民事管辖的范围之外,故应避免加以丝毫的干涉;要维护旨在保障私人权利、人身权利和出版自由的其他有益规定的全部活力;政府开支要厉行节约;要通过光荣地清偿公债以调动公共资源;要把常备军事力量控制在必要的限度以内,应时刻牢记,一支训练有素的武装民兵便是所有共和国最坚强的堡垒,没有常备军,他们的自由决不至于陷入危险的境地,而庞大的武装则未必意味着安全;要采用合法的手段推动有利于农业制造业和国内外贸易的各项改进措施;要以同样方式支持科学的进步和知识的传播,此乃真正自由的最佳养份;要继续执行慈善计划,这些计划一直都在值得称道地实施,以改造我们的土著邻居,使他们摆脱野蛮生活的堕落和不幸,得以分享文明状态下人们在心灵和举止上所惯有的各种改善成果。以上种种想法和打算,只要有助于我完成使命,便是不会令我失望的一个源泉。

The case study found: the boy's play therapy went through 3 phrases, including "knowing the therapeutic conditions well","establishing of therapeutic relationship","developing play therapy evolutionally"; the clues from which to judge relationship included "verbal and nonverbal interaction between therapist and the boy","the boy's dealing with his parents ","his 'first' behavior", the aim of establishing was to form "mother-child unity"; the relationship between therapist and the boy's parents passed through "admitting the facts","opening their feelings" and "detailed guidance"; the development of the boy's play consisted in the larger degree of digging and moving sand(showing that the therapy went deep into the boy's mind and his sense of strength was improving), the increasing of imaginative plays(showing that the boy began to pay attention to others and knew how to play), from playing by himself to cooperating with therapist(showing that he felt the happiness in cooperating and interacting with others and was gaining self-confidence which was favorable to be transferred to his lives and be used to communicating with others), sand and water were very important therapeutic factors for the boy(sand could mobilize his sense of feeling and touching , awakening his energy and regulating it. water could provide relaxed feeling, sense of being contained and satisfied and enlighten his imagination).

研究发现,个案的游戏治疗经历了三个阶段,即&熟悉治疗环境阶段&、&治疗关系建立阶段&和&游戏治疗深入发展阶段&;考察治疗关系建立的指标包括&个案与治疗者之间的言语和非言语互动&、&个案与父母的关系处理&和&个案的'第一次'行为&,建立的目标是&母子一体性&的形成;治疗者与个案父母关系的建立经过了&接纳事实&、&开放情感&和&具体指导&三个阶段;个案在治疗中游戏的发展表现为:动沙的力度增大,说明治疗深入了个案内心,其自我能量感在增强,游戏中的想象性成分不断增多,说明其对周围事物和他人关注了,开始&会&游戏,从单独游戏逐渐向简单合作游戏发展,说明其体验到了合作和互动的快乐,并从中渐渐获得自信,有助于个案将这种体验和自信迁移到日常生活中,尝试与他人互动;沙和水是个案游戏治疗中的重要治疗因素,沙可以调动自闭症幼儿的感触觉,唤醒其潜在能量,调整能量分配,水给自闭症儿童一种轻松感、包容感和满足感,并引发其想象。

The case study found: the boy"s play therapy went through 3 phrases, including "knowing the therapeutic conditions well","establishing of therapeutic relationship","developing play therapy evolutionally"; the clues from which to judge relationship included "verbal and nonverbal interaction between therapist and the boy","the boy"s dealing with his parents ","his "first" behavior", the aim of establishing was to form "mother-child unity"; the relationship between therapist and the boy"s parents passed through "admitting the facts","opening their feelings" and "detailed guidance"; the development of the boy"s play consisted in the larger degree of digging and moving sand(showing that the therapy went deep into the boys mind and his sense of strength was improving), the increasing of imaginative plays(showing that the boy began to pay attention to others and knew how to play), from playing by himself to cooperating with therapist(showing that he felt the happiness in cooperating and interacting with others and was gaining self-confidence which was favorable to be transferred to his lives and be used to communicating with others), sand and water were very important therapeutic factors for the boy(sand could mobilize his sense of feeling and touching , awakening his energy and regulating it. water could provide relaxed feeling, sense of being contained and satisfied andenlighten his imagination).

研究发现,个案的游戏治疗经历了三个阶段,即&熟悉治疗环境阶段&、&治疗关系建立阶段&和&游戏治疗深入发展阶段&;考察治疗关系建立的指标包括&个案与治疗者之间的言语和非言语互动&、&个案与父母的关系处理&和&个案的'第一次'行为&,建立的目标是&母子一体性&的形成;治疗者与个案父母关系的建立经过了&接纳事实&、&开放情感&和&具体指导&三个阶段;个案在治疗中游戏的发展表现为:动沙的力度增大,说明治疗深入了个案内心,其自我能量感在增强,游戏中的想象性成分不断增多,说明其对周围事物和他人关注了,开始&会&游戏,从单独游戏逐渐向简单合作游戏发展,说明其体验到了合作和互动的快乐,并从中渐渐获得自信,有助于个案将这种体验和自信迁移到日常生活中,尝试与他人互动;沙和水是个案游戏治疗中的重要治疗因素,沙可以调动自闭症幼儿的感触觉,唤醒其潜在能量,调整能量分配,水给自闭症儿童一种轻松感、包容感和满足感,并引发其想象。

The information technology in the physical teaching's utilization, must play teacher's leading role, takes student's main body status, arouses student's enthusiasm fully, lets the student from the observation, practice to the ponder, the conclusion, studies spiritedly; Must pay great attention in the teaching process the observation, the experience and the understanding, pays great attention to observe, to begin, the elaborative faculty raise and the enhancement; Must pay great attention the thinking in images the raise and the enhancement; Not only need achieve will eat the nimble ponder which the fish will fish, for active learning and for radiation thought study pattern.

从网络外语教学研究现状看网络外语教。。。教学日志:外语教师反思性教学的有效。。。信息技术在物理教学中的运用,要以发挥教师的主导作用,重视学生的主体地位,充分调动学生的积极性,让学生从观察、实践到思考、结论,生动活泼地学习;要以注重在教学过程中的观察、体会和理解,注重观察、动手、思考能力的培养和提高;要注重形象思维的培养与提高;要以达到不但会吃鱼更会钓鱼的灵活思考,为主动学习和为发散型思维的学习模式。

Small size projects in accordance with the specificity of the owners, from a good "way of life" point of view, are equipped with the exclusive nature of some of the characteristics of facilities, and often held in some fashion, such as nuts International Apartment private club of restaurant, home theater , study, drawing room four personalized clubs, from time to time after the New Town at the "ball people Kaifong will" and so on, these facilities and activities to mobilize the passion of young people, resulting in the desire to buy.

小规模的项目根据具体情况,所有者,从一个良好的&生活方式&的角度看,都配有专属性质的一些特色的设施,并经常举办一些时装,如坚果国际公寓私人俱乐部的餐厅,家庭影院,学习,个性化的客厅四个俱乐部,不时在新的城市在&球人街坊会&等,这些设施和活动,以调动激情的年轻人,导致购买的欲望。

The history classroom activities enormously arouse the students' interests in learning history as well as change the students' learning manners and the traditional "spoon-feed" way of teaching. The variety of classroom activities helps a combined action of the students' four sensory organs, which is also advantageous for the students to improve their ability. They not only help improve the students study, but also help in future development. The interactive process between teachers and students is a foundation of harmonious and democratic relationship between them which helps achieve the goal of progress both teachers and students.

通过开展历史课堂活动极大地调动了学生学习历史的积极性;改变了学生的学习方式,也改变了以往历史教学中&满堂灌&的教学方式;在形式多样的课堂活动中,学生的眼、口、耳、手共同作用,有利于学生各种能力的锻炼和提高,不仅有利于学生学业成绩的提高,还为其将来发展奠定了基础;在师生的互动过程中,构建了和谐民主的师生关系,实现了教学相长的目标。

This text will combine the psychological characteristics about the middle school student in psychology, according to the Chinese syllabus of middle school, on the basis of explaining content of courses of expository writing in an all-round way, discuss especially how to overcome the psychological obstacle that students think the expository writing stiff, uninteresting, arouse students enthusiasm to study expository writing, several kinds of methods to improve teaching result of the expository writing.

因此,怎样改进说明文的教学方法,提高学生学习说明文的兴趣,是中学语文教师不断研究、探讨的重要课题。本文将依据中学语文教学大纲,结合心理学中关于中学生的心理特征,在全面阐述说明文教学内容的基础上,重点探讨如何让学生克服学习说明文呆板、枯燥的心理障碍,调动学生学习说明文的热情,提高说明文的教学效果的几种方法。

It is it with request that law run a country, establish the system of perfecting the fire control law, manage the fire in accordance with the law to meet to want, build the socialist fire control state with an adequate legal system; Meet the needs of market economy, change the administrative management function of fire control, implement macroscopical management service, set up norm perfect , turn round coordinating , transparent high-efficient administrative management system of fire control; Arouse the enthusiasm that the society of various fields launches fire control work, set up the social mechanism of management of security against fire taken charge in unison and jointly administrate; Cultivate and develop fire control intermediary affairs not to organize in a more cost-effective manner , use market lever is it promote fire control to work to regulate, advance fire control work socialization; Meet the needs of socialist spiritual civilization, strengthen and improve the fire control propaganda work in a more cost-effective manner, cultivate and carry forward the modern firecontrol culture of the distinct Chinese characteristics, raise the whole peoples consciousness of security against fire and fire control quality; Meet the requests of the market economy and accession to the WTO of our country, strengthen the products management of fire control, advance the industrial modernization of fire control, realize the development of national fire control industry.

要适应以法治国的要求,建立健全消防法律体系,实行依法治火,建设社会主义消防法制国家;适应市场经济的要求,转变消防行政管理职能,实行宏观管理服务,建立规范完善、运转协调、透明高效的消防行政管理体制;调动社会各方面开展消防工作的积极性,建立齐抓共管的社会消防安全管理机制;大力培育和发展消防中介事务组织,运用市场杠杆调节促进消防工作,推进消防工作社会化;适应社会主义精神文明建设的要求,大力加强和改进消防宣传工作,培育和弘扬中国特色的现代消防文化,提高全民的消防安全意识和消防素质;适应市场经济和我国加入世贸组织的要求,加强消防产品管理,推进消防工业现代化,实现民族消防工业的振兴。

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Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来,英国,在此地早期居住的是凯尔特人,已经被征服了三次。

Bluetooth OBEX File Transfer Enables the sending and receiving of files on your phone via Bluetooth.

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The almost sure central limit theorem is a pop topic of the probability research in recent years,because it has many actual applications in the random analogue.

中文摘要:几乎处处中心极限定理是近几十年概率论研究的一个热门话题。它之所以引起人们的注意是由于它在随机模拟方面的实际应用参见Fisher