记忆障碍的

Abstract〕 Objective To explore the effects of traditional Chinese medicine ancient compound prescription Memory-Enhancing Decoction and optimized MED on memory improvement of dysmnesia animal, and verify the promotion of optimized MED on the expression of learning and memory molecular switch CREB gene.

目的：研究中药古方强记汤及天然脑活素对记忆障碍动物模型在记忆改善方面的作用效果；并运用转基因技术进一步验证天然脑活素对学习记忆分子开关 CREB 基因表达的促进作用。

Objective: To investigate the effects of exercises on learning and memory deffict induced by sodium nitrite in mice and determine the mechanism preliminarily.

目的：考察运动训练对亚硝酸钠致记忆障碍模型小鼠学习记忆能力的影响，并探讨其作用机制。

Methods:Phamaco1ogy studies adopt orycto1agus curicu1us athero-sclerosis and musculus remembrance function bindrance model, set modelgroup, void control group, positiye control group, and NLKC high, middle,low dose group. The effects were observed by monitoring the inf1unenceof NLKC on blood and aorta 1 ipid, hemorrheology, l ipid peroxidation (LP0),thromboxanceB: Y 6--keto--prostag1andinF1 Q (6--keto--PGF, Q ), thick-ness and stage of atherosclerosis plaque, pathology of aorta andcoronary artery, and remembrance function.

主要药效学选用家兔动脉粥样硬化模型、小鼠记忆障碍模型等，设立脑力康胶囊不同剂量组、模型组、空白对照组、阳性对照组等，观察脑力康胶囊对血脂、血流变、过氧化脂质、血栓素B2（TXB2）、 6－酮－前列腺素F10（6－keto－PGF10）、主动脉脂质含量、动脉粥样硬化斑块厚度及程度、主动脉及冠状动脉病理形态、增强记忆等方面的影响。

Methods: Random single blind method was used in clinical study to observe the clinical effect of YZD and compared with that of Ritalin. The dysmnesia model animal was used to observe the effect of YZD on learning memory function and cerebral monoamine neurotransmitter content.

临床研究采用单盲法随机观察益智丹与利他林的临床疗效；实验研究制作记忆障碍模型，观察益智丹对小鼠学习记忆功能和对小鼠脑组织单胺类神经递质含量的影响。

The Shenzhen Affiliated Hospital of South Medical University, Guangdong Shenzhen 518035）〔Abstract〕 Objective To explore the effects of traditional Chinese medicine ancient compound prescription Memory-Enhancing Decoction and optimized MED on memory improvement of dysmnesia animal, and verify the promotion of optimized MED on the expression of learning and memory molecular switch CREB gene.

目的：研究中药古方强记汤及天然脑活素对记忆障碍动物模型在记忆改善方面的作用效果；并运用转基因技术进一步验证天然脑活素对学习记忆分子开关 CREB 基因表达的促进作用。

Abstract〕 Objective To explore the effects of traditional Chinese medicine ancient compound prescription Memory-Enhancing Decoction and optimized MED on memory improvement of dysmnesia animal, and verify the promotion of optimized MED on the expression of learning and memory molecular switch CREB gene.

作者：吴正治李映红李明陈嫚茵杨敏目的：研究中药古方强记汤及天然脑活素对记忆障碍动物模型在记忆改善方面的作用效果；并运用转基因技术进一步验证天然脑活素对学习记忆分子开关 CREB 基因表达的促进作用。

Results Both of MED and optimized MED improved the memory results about latent time and error frequency of dysmnesia mouse models significantly comparing with model control group (P nbsp; 0.01), and the improvement of optimized MED was more noticeable than that of MED (P nbsp; 0.01). Comparing with control group, optimized MED up-regulated the expression of CREB gene significantly (P nbsp; 0.01), and the effect had a dose response relationship.

结果：强记汤及天然脑活素水煎液对动物记忆障碍模型小鼠记忆成绩中的潜伏时间、错误次数与模型对照组比较均有统计学意义（P 0.01）；而且天然脑活素的改善效果明显优于原方（P 0.01）；不同剂量天然脑活素水煎液 CREB 表达水平与对照组比较有统计学意义（P 0.01），且有剂量反应关系。

Methods the spf mice were treated with med or optimized med in dose of 29.3 g/kg and 18.6 g/kg per day respectively by intragastric administration for five days continuously. and then, the various dysmnesia mouse models were prepared respectively with scopolamine (3 mg/kg), cycloheximide (120 mg/kg) by intraperitoneal injection and 40% alcohol (0.1 ml/10 g body weight) by intrag astric administration on the sixth day.

将强记汤及天然脑活素分别以 29.3 g/kg和 18.6 g/kg 的量每日经口灌胃给予 spf 级小鼠，连续 5 d，第 6 天给药 1 h 后制备成记忆障碍模型，第 7 天给药 0.5~1 h 后分别用跳台法和避暗法测试记忆成绩；另用不同剂量（50 g/ml 和 150 g/ml）天然脑活素水煎液处理大鼠大脑 b104 cns 神经细胞，以荧光素酶方法检测 creb 表达水平。

Methods The SPF mice were treated with MED or optimized MED in dose of 29.3 g/kg and 18.6 g/kg per day respectively by intragastric administration for five days continuously. And then, the various dysmnesia mouse models were prepared respectively with Scopolamine (3 mg/kg), Cycloheximide (120 mg/kg) by intraperitoneal injection and 40% alcohol (0.1 mL/10 g body weight) by intrag astric administration on the sixth day. Next day, memory result was estimated by using Step-down Test and Dark-avoiding Test after the mice were administered for half or an hour.

将强记汤及天然脑活素分别以 29.3 g/kg和 18.6 g/kg 的量每日经口灌胃给予 SPF 级小鼠，连续 5 d，第 6 天给药 1 h 后制备成记忆障碍模型，第 7 天给药 0.5~1 h 后分别用跳台法和避暗法测试记忆成绩；另用不同剂量（50 g/mL 和 150 g/mL）天然脑活素水煎液处理大鼠大脑 B104 CNS 神经细胞，以荧光素酶方法检测 CREB 表达水平。

The mechanism may be related to reducing brain cholinesterase activity, inhibiting the accumulation of aluminium ions in brain, maintaining the normal level of Glu/GABA.Key words:Prepared Radix Rehmanniae; Learning and memorizing; Dysmnesia

结论熟地黄对于化学药品所致记忆障碍模型小鼠具有增强其学习记忆和空间记忆能力的作用，其作用机制可能与改善中枢胆碱能神经系统功能，降低脑内Al3 含量，保护脑组织及维持脑内Glu/GABA的正常水平有关。

Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来，英国，在此地早期居住的是凯尔特人，已经被征服了三次。

Bluetooth OBEX File Transfer Enables the sending and receiving of files on your phone via Bluetooth.

蓝牙OBEX文件移动允许经过蓝牙传送和接受文件。。。。