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To investigate the expression of cyclooxygenase-2(COX-2) in carcinogenesis lesions of oral submucous fibrosis, and the effects of arecoline on the expression of COX-2 in cultured human oral keratinocytes.

目的 探讨环氧合酶-2(COX-2)在口腔黏膜下纤维性变癌变组织中的表达,观察槟榔碱对人口腔角质形成细胞COX-2表达的影响。

Methods The expression of COX-2 in 10 specimens of normal oral mucosa, 30 specimens of OSF and 15 specimens of oral squamous cell carcinoma by SP immunohistochemistry. The COX-2 protein induction by arecoline in different concentration (30, 60, 90 uglmL), was analyzed by Western blotting in normal human oral keratinocyte.

应用免疫组化SP法检测15例OSF癌变组织,30例OSF组织,10例正常口腔黏膜中COX-2蛋白表达,western-blot法检测不同浓度槟榔碱(30、60、90ug/mL)对KC COX-2蛋白表达的影响。

Results(1) Insulin secretion and mRNA levels of PDX1 were significantly decreased in rats with Type 2 diabetes meilitus compared with the control group.(2) Compared with the diabetic group, insulin secretion and mRNA levels of PDX1 were significantly increased in the medium and high dose of arecoline groups.

结果:(1)高糖作用引起Wistar大鼠胰腺β细胞PDX1 及胰岛素mRNA 的表达水平显著下降(P<0.01);(2)1 mg/kg和5 mg/kg槟榔碱处理能显著上调高糖喂养Wistar大鼠胰腺β细胞PDX1与胰岛素mRNA表达水平(P<0.05,P<0.01)。

Each expression may perform arithmetic or logic operations, test conditions, etc.

每个表达可能执行算术或逻辑运算,测试条件等状况的资料都提供了投入,以及表达的结果。

Endometrial carcinoma ; human expression array ; gene expression ; polymerase chain reaction

子宫内膜肿瘤;人表达阵列;基因表达;聚合酶链反应

Similar results were observed as those of tissue array, showing that the expression of RIG-I was reduced significantly in HCC compared with that in para-tumor and normal liver tissue samples.

上述肝癌组织芯片免疫组化检测结果提示,在肝癌患者的癌旁组织中RIG-I蛋白广泛表达,且主要在核周胞质中分布,然而,在肝癌组织中RIG-I蛋白表达明显下调。

Decreased expression of RIG-I in human hepatocellular carcinomaFirst, with tissue array, we analyzed the expression of RIG-I in HCC, and found that 90%(27/30) of para-tumor samples were positive for RIG-I expression, but only 20%(6/30) of HCC samples were RIG-I positive.

然而,在30例肝癌患者的肝癌组织中,只有5例患者的癌组织中RIG-I蛋白表达为阳性,1例患者的癌组织中RIG-I蛋白表达为弱阳性,阳性率为20%。

The complex alterations of gene expression underlie the development of malignant phenotype of lung squamous cell carcinoma and the Atlas cDNA expression array is a useful method for describing the expression profiles.

Atlas微阵列表达分析滤膜是研究基因表达谱的较好方法。

In this technique, dATPα 32 P labeled cDNA from normal and tumor tissues was hybridized to identical human cDNA expression array membranes (containing 588 known genes).

结果发现:(1)与细胞死亡和增殖有关的基因IRP、Wnt 5A及癌胚抗原前体表达明显增高;(2 )与浸润有关的调节因子基因CD147表达异常增高。

Objective To investigate the effect of sodium arsenite combined with cigarette smoke solution on expression of Bcl-2 and Bax in rat lymphocytes and study their interaction.

目的 研究亚砷酸钠和香烟烟气溶液联合作用对凋亡相关基因Bcl-2和Bax表达的影响,并探讨它们对这2种基因表达的影响是否存在交互作用。

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Objective To investigate the effects of interleukin-1 β converting enzyme gene on the biologic characteristics of ovarian cancer cells.

目的 探讨白细胞介素-1 β转换酶的表达,对卵巢癌细胞生物学特性的影响。

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弯曲:这种病是最常见的原因查明腹泻病,在世界上。

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法院没有充分的考虑到黑社会的猖獗所带来的恐怖,这使得我们最穷、最可怜的市民每天生活在他们的阴影当中,成为在家的囚犯。