血压

One of the problems we have seen I that when we give a drug that reduces appetitive like the Melanocortin 4 receptor agonist, that that tends to raise the blood pressure and of course that is undesirable in treating hypertensive patients to have a further rise in blood pressure so we would like to understand the molecular signaling pathways in the brain that allow for appetite, metabolic function, and blood pressure to be differentially controlled and therefore attack those different targets in treating not only obesity but also hypertension.

我们所遇到的一个难题是，当我们使用一种药物减低食欲，如黑皮质素受体4，有可能会增加血压。当然，血压进一步升高对于治疗中高血压患者是不受欢迎的。所以在高血压和肥胖的治疗中，我宁愿了解脑影响食欲、代谢功能和血压的分子信号途径，由此寻找差异性控制、进而治疗不同的目标。

Blood pressure should be reduced to normal level to prevent heart and cerebral vessels to occur arteriolosclerosiswhen the blood pressure of hypertensive patient is not very highor the duration of illness is short. when blood pressure rises very high or the course of disease is long, blood pressure should be lowered to slightly higher than normal blood pressure level, so it can prevent arteriolosclerosis to be deteriorated further and can prevent the occurence of cerebral ischemia and infarction.

在血压升高幅度不大或起病不久的高血压患者，治疗时应将血压降至正常水平，以预防心脑血管发生动脉硬化；在血压升高幅度大或病程长者，治疗时应将血压降至比正常血压稍高的水平，即要防止动脉硬化进一步加重，也要预防脑缺血和脑梗塞的发生。

Results The high peak and low peak of 24 hour ambulatory blood pressure appeared in the morning and at night in all three groups, but the blood pressure curve was planter in NIDDM and the percentage of disappeared diurnal rhythm of ambulatory blood pressure (blood pressure at nignttime falls less than 10%) was 66%, higher than in EHP (54%) and normal control (50%), the damagement of autonomic nerves appeared in 75%of NIDDM and 69%of EHP, but no relationship was observed between ambulatory blood pressure and urinary protein excretion rates.

结果 三组受试者服药前动态血压皆有昼高夜低的规律，但NIDDM的动态血压曲线更平坦；且昼夜节律消失(夜间血压下降低于10%)发生率为66%，高于EHP(54%)和正常对照组(50%)；NIDDM和EHP组分别有75%和69%的患者出现不同程度的自主神经功能损伤，但动态血压与尿蛋白排泄率间无相关性。

The different methods of blood pressure measurement and vital microcirculation observation method were used . The systemic blood pressure, arteriolar and capillary blood pressure decreased significantly after 3 months of Linzhi administration in addition to the routine hypotensor in 27 cases of refractory primary hypertension.

用各种血压测定法及活体微循环观察法发现，40例难治性高血压病人（治疗组27例，对照组13例）口服灵芝3个月后在大动脉血压、小动脉血压和毛细血管血压下降的同时，病人血粘度（高切、低切时的全血粘度及血浆比粘度）、红细胞压积和红细胞沉降率明显下降（P＜0.05），甲襞微血管数增多、口径扩大、流速加快（P＜0.05），血糖明显下降（P＜0.05），但胆固醇、甘油三酯及高密度脂蛋白下降不明显（P＞0.05）。

We obtained the penile pressure with a Doppler stethoscope and compared the penile-brachial index to the papaverine test for an evaluation of impotent patients.关键词 intracorporeal papaverine injection , priapism , penile-brachial index

我们同时利用都卜勒测量这些病人的阴茎血压，将阴茎血压除以手臂血压求得阴茎臂血压比(penile-brachial index，简称PBI)，其比值与譻粟碱试验结果相关连。

Venous blood was drawn from 35 old hypertension patients when blood pressure was nomial and abnormal, respectively. Epinephrine. norepinephine, endothelins, angiotensin Ⅱ and calcitonin-gene-related peptide were determined by radio-immunity. The above five cytokines were also determined in 33 old healthy people. The cytokines levels were compared between the normal and abnormal blond pressure in hypertension patients and also between the old hypertension patients and healthy persons. The correlation between blood pressure and cytokines were analyzed.

35例老年EH患者，血压正常时和血压波动时各抽取静脉血一次，放射免疫法检测肾上腺素、去甲肾上腺素、内皮素、血管紧张素Ⅱ和降钙素基因相关肽水平，同时检测33例健康老年人群各因子水平，比较EH患者血压波动前后各因子水平的差异和血压正常范围时两组人群各因子水平差异，分析不同状态下血压和各因子水平之间的相关性。

Results: six patients with vagal reflection were cured by intravenous atropine, 2 with pericardial hemorrhage were treated by pericardiocentesis, 1 patient developed hypotension due to occlusion of the mitral valve orifice by the catheter was corrected by shortening the duration of the catheter in left ventricle, the blood pressure of 1 patient with rapid atrial flutter was elevated by intravenous cedilanid, the blood pressure of 1 patient with hypotension of unknown origin was elevated by vasopressor and atropine.

结果：其中迷走神经反射6例，经静脉注射阿托品纠正；心包出血2例，心包穿刺抽液血压至正常；球囊导管阻塞二尖瓣口1例，缩短导管停留在左心室时间，可以避免低血压反应；快速心房颤动1例，使用西地兰减慢心室率，血压回升；原因不明1例，经使用升压药及阿托品后血压改善。

Three-quarters of the patients showed nocturnal nondipping of blood pressure, the authors report, but their systolic blood pressure during the day did not differ from that of patients with nocturnal dipping, and the diastolic blood pressure of nondippers was een lower than that of dippers.

研究人员声称，四分之三的患者表现出夜间非勺形血压，但是他们在白天的收缩压与夜间勺形血压患者并无两样。非勺形血压患者的舒张压甚至比勺形血压患者更低。

Noninvasive ambulatory blood pressure monitoring and genotyping by polymerase chain reaction amplification of all subjects were performed. The patients were then classified into four groups according to their dipping status: extreme dippers, dippers, non-dippers, and risers.

参与研究之高血压患者依其二十四小时血压纪录分为四类型：夜间血压下降极明显者、夜间血压下降明显者、夜间血压下降不明显者(non-dippers)、和夜间血压上升者。

In the latter groups, rats were bled to a mean arterial blood pressure of 40 mm Hg(1 mm Hg=0.133 kPa) and maintained at this level for 1, 2, 3 hours, respectively. The pressor response of blood pressure and the contractile response of superior mesenteric artery to norepinephrine(NE, 3 μg/kg) were observed after shed blood was reinfused.

第一部分实验用32只大鼠，随机分为手术对照组、1 h低血压组，2 h低血压组和3 h低血压组，每组8只动物；动物经股动脉插管放血至血压40 mm Hg(1 mm Hg=0.133 kPa)分别维持1、2和3 h，然后回输全部残余失血，观察回输血后1、2和3 h血压和肠系膜上动脉对去甲肾上腺素（NE，3 μg/kg ）的反应性变化。

Objective: To study the effect of polycythemia on blood oxygen saturation.

裴蕾目的：观察RBC剧增而引起的高粘血症对血氧饱和度的影响。

Based on SIMPLER algorithm in the curvilinear body-fitted coordinates, the calculations were performed for Pr=0.7, Re=10~1000 on non-orthogonal non-staggered grids which are generated by elliptic equation systems.

采用曲线坐标系下压力与速度耦合的SIMPLER算法，数值研究了周期性渐扩渐缩波纹通道内脉动流动与换热情况，流动Re数的范围为10~1000，Pr数为0.7。