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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle,CP)和两个19S调节颗粒(regulatory particle,RP)组成的ATP(adenosine-triphosphate,ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心,它是由4个圆环堆叠形成的桶状复合物,其中两侧外环每个环是由α_1-α_7亚基组成,两个内环每个环是由β_1-β_7亚基组成,4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔,其内壁为催化活性位点所在地;外侧α环中心的孔道是底物到达催化中心空腔的通道,一般被α亚基上的N末端所封闭,阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

The inner diameter of b-CD cone is 0.65nm and the extra is 1.53nm. The hydroxyl groups of C(6)(the sixth carbon atoms of glucose unit and the same as follows) are located on the smaller opening of the cone with counterclockwise direction, while the hydroxyl groups of C(2) and C(3) are located on the larger opening of the cone with reverse direction.

环糊精外型是内空的圆台形,其中β-环糊精内空腔的直径为0.65 nm,外径为1.53nm.C(6)(葡萄糖单元上第六个碳,下同)上的羟基位于空腔的细口端指向逆时针方向,C(2)、C(3)上的羟基位于空腔的宽口端指向相反的方向。

By using of the theory and simulation methods above, the inject cavity, buncher cavity and output cavity are analysed separably. With An annual electron beam of voltage 500kV, and current 3kA, average output microwave power 455MW and peak power 1.3GM is observed, bandwidth is 60MHz, the efficiency is 30.3%, the gain is about 36.8dB.and the frequency is 2.85GHz, The amplitude and phase of output microwave is stable.

最后运用上面所得出的一系列理论及模拟方法,分别对相对论速调管的注入腔、聚束腔和输出腔的工作特性进行了详细的分析和优化设计,我们采用3kA和500kV的环形强流相对论电子束,最后得到了工作频率为2.85GHz、饱和增益为36.8dB、效率为30.3%、带宽大约60MHz、平均功率为455MW,峰值功率可达1.3GW的微波输出的相对论速调管,输出微波的幅值平稳,相位稳定。

The force for filtering and backwashing is from water press and pump pressure.The pressure in filtering chamber will keep same.The solution will be filtered out from inner chamber of filtering core.The solid impurity will remain on the inner surface of filtering coThe pressure difference between outer and inner chamber and.filtering resistance will be increase.

该机的过滤和反冲洗推动力均原水压头或泵杨程提供,系统滤腔的压力基本保持恒定,液体从滤芯的内腔向外流动,夹带的固体杂质被截流在过滤介质的内表面,引起内外腔压差升高,过滤阻力逐渐增大。

It was shown that, the flow pattern in the EMPT was more complex than that in traditional one, that is, in the column chamber, the short circuit flow from the outlet nozzle of the ladle was depressed by the rotating molten steel, and horizontal recurrent flow appeared in rectangular chamber, which prolonged the average staying time of the molten steel, then reduced the volume fraction of inactive area in EMPT.

结果显示,电磁净化中间包的流场比传统中间包的流场复杂:在圆形腔中,旋转运动抑制了大包水口至矩形腔的短路流,而在矩形腔中形成水平环流,从而延长钢液在中间包的平均停留时间,死区减小,电磁净化中间包的上述流场结构及传输行为对钢液中的非金属夹杂物去除非常有利。

The coupling characteristics of the bicrystal Josephson junction with the Fabry-Perot resonator have been investigated experimently, showing that it was greatly affected by the factors such as the location of the sample in the open resonator, the angle between them, the pattern of the junction and the distance between the two reflecting mirrors of the resonator.

重点研究了双晶约瑟夫森结与Fabry-Perot谐振腔的耦合特性,发现放置在谐振腔中的结的位置、角度、结的图形以及Fabry-Perot谐振腔中两镜面间的距离等对耦合都有很大的影响。

Such plants usually have one or more domatia, cavities in stems, leaves or roods that house ants. These may be elaborate systems of cavities with many chambers, e.g. Myrmecodia, or simple hollows in internodes, leaf veins, petioles or stipular spines, e.g. whistling thorns.

这类植物通常都具有一个或多个虫菌穴,虫菌穴是在植株的根、茎、叶上用来容纳蚂蚁的空腔,这些空腔具有许多发达的小室,例如茜草科具有简单而中空的结间部,阿拉比卡咖啡具有含有空腔的叶脉,有的植物叶柄及托叶处也有这样的结构,例如牛角刺槐。

Results indicate:(1) The newly developed simulation technology can form fairly average and easily controllable back pressure downstream the inlet, so it can he used to investigate the back pressure characteristics of hypersonic inlets.(2) By regulating the valve of injection pipe, the simulation technology can realize the switch of hypersonic inlet started state and unstarted state in about 8 milliseconds, so it is suitable to investigate the starting/unstarting/resarting problem of hypersonic inlets.

结果表明:(1)所提出的凹腔喷流技术可在进气道下游形成较为均匀的、可控的背压环境,因此可用于进气道的反压特性研究;(2)适当调节凹腔的喷流总压,并在实验中实时控制阀门的开度,凹腔喷流技术能够在较短的风洞实验时间内(约8s)实现进气道起动、不起动、再起动流态之间的切换,因此可用于进气道的不起动/再起动特性研究。

Plastic Injection the design process, which is designed as part of the craft-oriented establishment : Plastic Parts of the Process Analysis, Plastic Parts of the size and quality of calculation and the injection parameters set; Structural design : Surface choice cavity determination, Cavity the arrangement, gate design, lateral type pulling mechanism design, launch and reattached body identified; Core, Cavity size calculation; Die heating and cooling system computation; Mold closing high set; Injection machine parameters in the verification; The design of such a structure can be used to ensure reliable die.

注塑模中文摘要翻译成英文摘要???帮帮忙~~~救急啊塑料注射的设计过程,其中的设计内容有零件的工艺性编制:塑件的工艺性分析、塑件的体积和质量计算及注射机参数的确定;结构设计:分型面选择、型腔数确定、型腔的排列方式、浇口设计、侧向分型抽芯机构设计、推出及复位机构方式确定;型芯、型腔尺寸计算;模具加热和冷却系统计算;模具闭合高度确定;注射机有关参数的校核;如此设计出的结构可确保模具工作运用可靠。

Based on the first law of thermodynamics and the law of mass conservation, a thermodynamic model of the back-pressure cavity has been developed by considering influence by back pressure cavity, compression chamber and oil supply system.

本文在热力学第一定律及质量守恒定律的基础上,建立了背压腔的热力模型,模型详细考虑了背压腔与工作容积、压缩机内油路之间的联系,并通过他们之间的联系给出了背压腔压力的计算方法。

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