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Compression of nerve roots often produces objective sensory changes early, with paresthesia and loss of sensating detectable in the affected dermatome.

神经根受压常很早即产生客观的感觉变化,在受影响的皮节区有感觉异常及感觉缺失,神经根持续受压,可发生运动肌无力,若累及腰4神根,可见膝腱反射减弱和轻度股四头肌无力,小腿肌肉感觉减退。

Compre ion of nerve roots often produces objective se ory changes early, with paresthesia and lo of se ating detectable in the affected dermatome. With continued root compre ion. Motor weakne may develop. With involvement of the L4 root, the patellar tendon reflex may be diminished and slight quadrice weakne may be o erved.

神经根受压常很早即产生客观的感觉变化,在受影响的皮节区有感觉异常及感觉缺失,神经根持续受压,可发生运动肌无力,若累及腰4神根,可见膝腱反射减弱和轻度股四头肌无力,小腿肌肉感觉减退。

Muscle type AchR is an important medium of neuronal transmission and main immunogen of Myasthenia gravis,as well as some diseases were induced by the mutation of neuronal\|typed AchR.

肌肉型乙酰胆碱受体是肌肉神经传导中的重要媒介物质以及自身免疫疾病重症肌无力的主要免疫原,神经型乙酰胆碱受体的突变也可导致某些疾病的发生。

Results Among 1 083 patients, polyneuritis, acute myelitis, periodic paralysis men with A blood type; trigminal neuralgia, Guillian-Barre syndrome were more of ten in men with B blood type;virus meningitis, women with sclerosis, epilepsy, myasthenia gravis,were more of ten in women with O blood type. The A, B, O blood type component proportions of the diseases mentioned above and those of the normal people have statistic differences. This presents that people with A, B, or O blood type are easy to catch those diseases.

结果 1 083例患者中,多发性神经炎、急性脊髓炎、周期性瘫痪3种疾病男性A型血居多;三叉神经痛、格林巴利综合征两种疾病男性B型血居多;病毒性脑炎的男性、多发性硬化的女性、癫痫和重症肌无力的女性O型血居多,其A、B、O 血型构成比与正常人比较差异有统计学意义(P 。05、。01),提示A、B、O血型的人易患上述疾病。

D. With myasthenia gravis, weakness of the bulbar muscle causes problems with chewing and swallowing, and presents a danger of choking and aspiration.

重症肌无力患者球肌无力引起咀嚼和吞咽问题,存在噎塞和误吸的危险。

In the article, we took part sample out of 158 patients to exam the expression level of Bcl-2 and Fas in myasthenic thymus tissue, and to find the role of which in whole pathogenesis. we also try to find the role of neopterin and sIL-2R through examing the concentration of neopterin and sIL-2R in peripheral blood of 26 MG patients. Material and methods1.select of case: to choose 158 patients who wear followed up from 1988 to 2002 after operation. All patients were diagnosed as MG, and treated with same medical cure during period of preoperation and post operation. 2.Collectionofdata:.To collect all data through designing a uniform follow-up table for thymectomized patients ,and to analysis the effect of factors including age, gender, disease duration of preoperation, clinic types and pathological types to prognosis at three follow-up period?

本文拟在对全组病例的远期预后进行流行病学统计分析的基础上,通过抽取一定量样本,研究重症肌无力患者胸腺组织中伽 12、Fas的异常表达及生发中心的形成在重症肌无力发病机制中可能的作用,以及它们对胸腺切除术后远期预后的影响;与之相似,通过检测部分样本外周血清中新碟吟和可溶性IL-2受体的浓度及其与正常对照组的差异,以期推测两者在重症肌无力起病及病情进展中的作用和意义,并分析其对胸腺切除术后远期预后的影响。

Myasthenic symptom was not clianged in one patient for whom radiotherapy had been standed before operation nor during the course of postoperative radiotherapy.

单次剂量1.8~2.0Gy的照射方式不会加重肌无力症状,但放疗中必须应用合理的抗胆碱酯酶药物,密切观察肌无力变化,及时调整药物治疗方案。

There is usually little or no progression, the EMG shows non-specific myopathic features and serum CK is normal or only slightly raised.1 The muscle biopsy may show characteristic ultrastructural abnormalities but these can be difficult to detect without specific histochemistry and/or electron microscopy that were not available in 1981 when our patient was biopsied.

查体提示:双侧眼睑下垂,易疲劳;轻度面部及颈部肌肉无力;舌肌无力并出现中央沟。无眼肌麻痹。肩部上肢带肌消瘦、明显无力,可见肩胛翼。腰部无力,行走时脊柱前凸,呈&鸭步&步态。坐位是如不用双手辅助,可能掉出椅子外。但可以依靠其脚趾和足跟站立。患者肺活量为正常的80%,心电图及超声心动图正常。CK水平为正常的2-3倍。

Objective To study the clinical feature of myasthenia gravisonset after thymectomy,and relationships between thymoma and MG.

目的 分析胸腺瘤术后发生的重症肌无力的临床特点,进一步认识胸腺瘤与MG的关系。

The immunoglobulin like anti AChR antibody without complement binding activity is successfully made from a pathogenic anti AChR antibody IgG 637 by site directed mutagenesis.Key words:receptor, cholinergic;myasthenia gravis;point mutation;complement-binding;antibodies

本研究利用定点突变技术,从完型抗乙酰胆碱受体抗体IgG 637制备了不能激活补体的突变型抗乙酰胆碱受体抗体IgG 637/K 322 A,为最终制备出可用于治疗重症肌无力的无补体激活功能的单价抗乙酰胆碱受体抗体提供依据。

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