给予...大剂量

Methods Fourty male Wistar rats were randomly divided into four groups on the basis of body weight: control group, low, moderate and high alcohol group.

清洁级雄性Wistar大鼠40只，按体重随机分为对照组和低、中、高酒精剂量组，每天分别给予0，0.8，1.6和2.4g/的酒精灌胃。

This study demonstrated that KA administration in a convulsant dose could result in spontaneous recurrent seizures and permanent disturbances of behavior and cognition in old rats (P25、P60) which brains were in mature. However temporal and reversible effects occurred in rat pups (P5、P15) in immature brain.

一次给予惊厥剂量的KA可诱发脑发育成熟大鼠（P25、P60）出现自发癫痫发作，但在脑发育未成熟大鼠（P5、P15）中未见有自发癫痫发作；KA致痫对脑发育成熟大鼠造成的认知行为异常持久而不可逆，但对脑发育未成熟幼鼠认知行为的影响则持续时间短而可逆。

The epilepsy model induced by kainic acid is a dynamical model condition. 5-7 days after acute seizure episodes induced by a single systemic injection of a convulsant dose (10mg/kg) of KA the rats developed a long-lasting increase in seizure susceptibility and the characteristic histopathological features in the hippocampus similar to human TLE. So the KA model has been a well-known model to study TLE or intractable epilepsy.

颞叶癫癎红藻氨酸（kainic acid，KA）模型具有明确的动态变化过程，一次全身性给予惊厥剂量（10mg/kg）KA诱发SD大鼠急性癫癎发作后5-7天，动物开始出现癫癎发作敏感性长期增强，脑内亦发生与人类颞叶癫癎相似的神经病理、神经生化及神经分子生物学方面的改变，因此被认为是研究颞叶癫癎和难治性癫癎的理想模型之一。

Methods Estradiol-randomly methylated β-cyclodextrin (E2-RAMEB) solution, and 70% ethanol solution of estradiol and estradiol nasal spray in 3 different doses 0.16、0.48、1.60 mgkg^(-1 were nasally administrated to rats, respectively. Non-compartment statistical moment method was used in pharmacokinetics study.

对大鼠鼻腔给予雌二醇-随机甲基化β-环糊精包合物的生理盐水溶液、雌二醇乙醇溶液和3种剂量的雌二醇鼻腔喷雾剂，用非隔室模型统计矩法进行了药物动力学研究，并与静脉注射雌二醇相比较计算绝对生物利用度。

Results The levels of HSP 70 mRNA and HSP 70 protein expression were significantly different among the 5 groups. Ketamine induced marked HSP 70 mRNA and HSP 70 protein expression in the posterior cingulated cortex. Propofol itself did not induce HSP 70 gene expression in this brain region. Propofol significantly inhibited ketamine-induced HSP 70 mRNA and HSP 70 protein expression in the posterior cingulate cortex in a dose-dependent manner.

结果氯胺酮可明显诱导HSP70 mRNA与HSP70蛋白在大鼠后扣带回皮质区的表达；异丙酚自身不能诱导HSP70基因的表达；预先给予异丙酚可显著抑制氯胺酮诱导的HSP70 mRNA和HSP70蛋白在这一区域的表达，且抑制效应呈剂量依赖性。

Methods the spf mice were treated with med or optimized med in dose of 29.3 g/kg and 18.6 g/kg per day respectively by intragastric administration for five days continuously. and then, the various dysmnesia mouse models were prepared respectively with scopolamine (3 mg/kg), cycloheximide (120 mg/kg) by intraperitoneal injection and 40% alcohol (0.1 ml/10 g body weight) by intrag astric administration on the sixth day.

将强记汤及天然脑活素分别以 29.3 g/kg和 18.6 g/kg 的量每日经口灌胃给予 spf 级小鼠，连续 5 d，第 6 天给药 1 h 后制备成记忆障碍模型，第 7 天给药 0.5~1 h 后分别用跳台法和避暗法测试记忆成绩；另用不同剂量（50 g/ml 和 150 g/ml）天然脑活素水煎液处理大鼠大脑 b104 cns 神经细胞，以荧光素酶方法检测 creb 表达水平。

Methods The SPF mice were treated with MED or optimized MED in dose of 29.3 g/kg and 18.6 g/kg per day respectively by intragastric administration for five days continuously. And then, the various dysmnesia mouse models were prepared respectively with Scopolamine (3 mg/kg), Cycloheximide (120 mg/kg) by intraperitoneal injection and 40% alcohol (0.1 mL/10 g body weight) by intrag astric administration on the sixth day. Next day, memory result was estimated by using Step-down Test and Dark-avoiding Test after the mice were administered for half or an hour.

将强记汤及天然脑活素分别以 29.3 g/kg和 18.6 g/kg 的量每日经口灌胃给予 SPF 级小鼠，连续 5 d，第 6 天给药 1 h 后制备成记忆障碍模型，第 7 天给药 0.5~1 h 后分别用跳台法和避暗法测试记忆成绩；另用不同剂量（50 g/mL 和 150 g/mL）天然脑活素水煎液处理大鼠大脑 B104 CNS 神经细胞，以荧光素酶方法检测 CREB 表达水平。

Methods Seventy-five SD rats were randomized into five groups: normal, model, iodine glycerin (20 g/L), high-dose SP (200 g/L) and low-dose SP (100 g/L). The experimental periodontitis rat models were established by ligating molars with steel wire combined with intramuscularly injection of prednisolone (1.25mg, 8 times). Except that the model and normal groups were treated by applying saline, the other groups were treated by applying the corresponding drugs 0.5 mL to the peridentium, tid for 10 days. After treatment, debris index, probe depth and bleeding rate during probing were investigated and the pathological changes of periodontal tissues were also observed.

方法］SD大鼠随机分为正常组，模型组，碘甘油组(20g/L)，舒口散高、低剂量组(200、100 g/L)；采用钢丝结扎牙齿加肌注波尼松龙（l.25 mg/次，共8次）的方法复制大鼠实验性牙周炎模型；药物采用口腔局部涂搽，每次0.5mL，每日3次，10 d为1疗程，模型组与正常组给予等容积生理盐水；检测各组软垢指数、探诊深度、探诊出血阳性例数，并取牙周组织进行病理学检查。

In our studies, the treatment of colo 205 cells with 10,20,30,40 or 50 μM Aloe-emodin will decerased the cell viability in a dose- and time-dependent manner.

在我们的实验结果中发现，大肠癌细胞给予芦荟大黄素10、20、30、40及50 μM处理后，结果发现芦荟大黄素对於细胞毒性的产生，具有时间上及剂量上影响。

Methods Sixty Wistar rats were randomly divided into two experimental groups (50 rats) and control group (10 rats). The experimental group rats were kindled by repeated peritoneal injection of sub-convulsive dose of pentylenetetrazol.

将60只大鼠随机分为实验组50只和对照组10只；实验组给予亚抽搐剂量戊四氮腹腔注射，其中45只大鼠确定点燃，将其随机分为给药组35只和未给药组10只。

In her eyes, because that is the doorway toher heart * the place where love resides.

女人的漂亮必須從她的眼睛中去看，因為那是她心靈的窗戶和愛居住的地方

I will send some postcards to you.

我会向你发送一些明信片。