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Objective To study the effect of endomorphin on dynamic changes of cathartic colon and investigate the pathogenesis of slow transit constipation.

目的 研究内吗啡肽对"泻剂结肠"大鼠结肠动力的影响,以探讨慢传输性便秘的发病机制。

Objective: To explore the causes and pathogenesis of melanosis coli as well as its relationship with age, sex and colorectal neoplasm.

目的:探讨结肠黑变病的病因、发病特点以及结肠黑变病与年龄、性别、结肠肿瘤的关系。

Animals tests showed that sphingomyelin could inhibit the development of abnormal colon crypt and colon tumor or cancer of ICR MOUSE induced by 1,2-dimethylhydrazine, by contributing to the protein expression of PCNA and Connexin26 in the tumor or cancer tissue, so sphingomyelin was considered to have the function of preventing colon cancer.

动物实验研究发现鞘磷脂能通过影响肿瘤组织中PCNA和Connexin 26蛋白表达,抑制1,2-二甲肼诱导的ICR小鼠异常结肠隐窝和结肠肿瘤的发生,因此对结肠癌有一定的预防作用。

ResultsThe combination of Changdiqing and Changyanqing could significantly improve the symptoms of diarrhea and hematochezia, decrease the ulcer index of colonic mucosa,aleviate the pathological changes, increase SOD activity in serum and tissues of colon, and decrease the level of MDA in UC model rats compared with normal saline enema and the other two treatment groups.

结果与模型组和其他两个治疗组比较,肠涤清+肠炎清可以显著改善UC大鼠的腹泻和便血情况,减轻结肠黏膜损伤指数,改善结肠黏膜的病理形态学情况,提高血清和结肠组织中SOD活力,降低血清和结肠组织中MDA含量。

In order to study the clinical value of fibro-colonoscopic examination for guiding coloclyster of congenital megacolon,70 cases of CM were divided randomly into control group (n=35,without receiving the examination of fibro-colonoscope) and observed group (n=35,undergoing the examination of fibro-colonoscope).

为研究应用纤维结肠镜检查指导先天性巨结肠结肠灌洗的临床价值,将70例先天性巨结肠手术病例分为对照组35例,按常规灌洗;观察组35例,应用纤维结肠镜检指导灌洗。

Objective To analyse the clinical and radiologic appearance of congenital microcolon,get the primary disease.Methods 12 cases of congenital microcolon were reviewed to the clinical and radiologic appearance.

目的 分析细小结肠症的临床及X线表现,以便诊断原发疾病方法搜集我院资料完整的先天性细小结肠症患者12例,就其临床及X线表现进行回顾性分析。

Using rectal swabbings or the colon brush method, cytologic studies of ulcerative colitis, irritable colon, intestinal tuberculosis,amebic colitis and cancer of the large bowel were done.

用直肠刷或结肠刷的方法取样,采用细胞学研究溃疡结肠炎、过敏性结肠、肠结核、变形虫结肠炎和大肠癌。

In conclusion, tobacco specific carcinogen, NNK, enhanced colon cancer metastasis through α7-nAChR and E-cadherin — one of the hallmarks of epithelial mesenchymal transition — and its transcription repressors, Snail and ZEB1. Besides, the nicotine also enhanced the colon cancer cell migration through non-E-cadherin pathway.

从我们的实验得知菸草中的致癌物质NNK能透过结肠癌细胞上的α7尼古丁受器而改变E-cadherin转录及其转录抑制因子(Snail和ZEB1)的表现量来增加结肠癌细胞的转移能力,而尼古丁则是透过E-cadherin以外的途径来促进结肠癌细胞转移。

Results Well-resolved, reproducible 2-DE profiles of human colon carcinoma tissues and paired normal tumor-adjacent colon tissues were obtained. For colon carcinoma tissues, a total of (980±28) spots were detected; for paired normal tumor-adjacent colon tissues,(860±45) spots were detected. For normal tumor- adjacent colon tissues, the average deviation of spot position was (10.487±0.11) mm in IEF direction and (0.944±0.12) mm in SDS-PGE direction; for colon carcinoma tissues the average deviation of spot position was (0.654±0.11) mm in IEF direction and (1.20±0.22) mm in SDS-PGE direction. Number of differentially expressed proteins was 72.00±12.34 between colon carcinoma and paired normal tumor-adjacent colon tissues.

结果 建立了结肠癌及正常肠组织的双向凝胶电泳图谱,其中癌旁正常结肠组织和结肠癌组织电泳图谱中平均蛋白质点数分别为860±45和980±28;癌旁正常结肠组织和结肠癌组在IEF方向上的平均偏差分别为(0.487±0.11)mm和(0.654±11)mm,在SDS-PAGE方向上的平均偏差分别为(0.944±0.12)mm和(1.20±0.22)mm,结肠癌与癌旁正常结肠组织的差异表达蛋白质点数为72.00±12.34。

Aimed at current practitioners and trainees, the book discusses key concepts that will assist general surgeons and colorectal consultants in their management of patients with a broad spectrum of anorectal and colonic disorders.

针对当今的开业医生和学员,书讨论将帮助一般外科医生和结肠直肠顾问在他们病人与一anorectal 和结肠紊乱的宽范围一起的管理内的核心概念。

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