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The results indicated that Erzhu fuling san and the decoction of Rhizoma atractylodis and Rhizoma atractylodis macrocephalae could both restrain the movement of intestine, reduce its contract and diastole tension and contract swing, the decoction of Rhizoma atractylodis macrocephalae could excite the un-striped muscle and enhance the tension and swing of chook's isolated jejunum.

结果表明,二术茯苓散和其组分药苍术、茯苓水煎液均能抑制肠管的运动,使鸡离体空肠收缩张力和舒张张力降低,收缩振幅减小;白术水煎液对鸡离体空肠平滑肌有兴奋作用,可使肠管张力增强,收缩振幅增大。

The results showed that coadministration of 2 g/kg SR at 1.5 h and 3 h after MTX significantly increased the AUC720-3600 of MTX by 68 % and 52 % and increased MRT by 64% and 76 %, respectively.

结果显示,於 MTX 给药后1.5小时、3 小时并服2 g/kg 黄芩水煎剂对 MTX 之血药面积 AUC0-3600 显著提高了 68 %和 52 %;平均滞留时间显著提高了 64 %和 76 %。

Methods the spf mice were treated with med or optimized med in dose of 29.3 g/kg and 18.6 g/kg per day respectively by intragastric administration for five days continuously. and then, the various dysmnesia mouse models were prepared respectively with scopolamine (3 mg/kg), cycloheximide (120 mg/kg) by intraperitoneal injection and 40% alcohol (0.1 ml/10 g body weight) by intrag astric administration on the sixth day.

将强记汤及天然脑活素分别以 29.3 g/kg和 18.6 g/kg 的量每日经口灌胃给予 spf 级小鼠,连续 5 d,第 6 天给药 1 h 后制备成记忆障碍模型,第 7 天给药 0.5~1 h 后分别用跳台法和避暗法测试记忆成绩;另用不同剂量(50 g/ml 和 150 g/ml)天然脑活素水煎液处理大鼠大脑 b104 cns 神经细胞,以荧光素酶方法检测 creb 表达水平。

Methods The SPF mice were treated with MED or optimized MED in dose of 29.3 g/kg and 18.6 g/kg per day respectively by intragastric administration for five days continuously. And then, the various dysmnesia mouse models were prepared respectively with Scopolamine (3 mg/kg), Cycloheximide (120 mg/kg) by intraperitoneal injection and 40% alcohol (0.1 mL/10 g body weight) by intrag astric administration on the sixth day. Next day, memory result was estimated by using Step-down Test and Dark-avoiding Test after the mice were administered for half or an hour.

将强记汤及天然脑活素分别以 29.3 g/kg和 18.6 g/kg 的量每日经口灌胃给予 SPF 级小鼠,连续 5 d,第 6 天给药 1 h 后制备成记忆障碍模型,第 7 天给药 0.5~1 h 后分别用跳台法和避暗法测试记忆成绩;另用不同剂量(50 g/mL 和 150 g/mL)天然脑活素水煎液处理大鼠大脑 B104 CNS 神经细胞,以荧光素酶方法检测 CREB 表达水平。

Results: With the increasing of the concentration of the fleece-flower root decoction and the rhubarb decoction, the frequency of the MCN and the SCE aslo rising, we can evident observe the chromosome adhesion by microscopic in the fleeceflower root 1772mg/kg group.

结果:随着何首乌煎剂与大黄煎剂给药浓度的增加而SCE和MCN频率也不断提高,其中何首乌1772mg/kg组通过镜检明显看出染色体发生粘连。

Place these herbs into the ready decoction and put the lid on for fifteen minutes.

这些药放入已煎好的药汁里,加盖泡15分钟。

The DT and AD of maximal toxicity of RA decocted liquids were 30 minutes and 120 times.

川乌水煎液毒性最大的煎煮时间和给药剂量是30 min,120倍。

RA decocted liquids with DT 30 min and AD 120 times have the maximal toxicity and the best medicinal effect.

结论煎煮30 min,给药剂量为临床用量120倍时,川乌水煎液对痹证动物产生的毒性最大,但药效最佳。

objectiveto study the correlation between decocting time,administration dosage and the toxicity of radix aconiti.methodsaccording to uniform designed technology, ra was decocted with different duration of 15 minutes, 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours and 6 hours,and the content of ra was 6 times, 12 times, 24 times, 48 times, 72 times, 96 times, 120 times of clinic ad respectively.

作者单位:1。广东省中药研究所,广东广州 510520;2。成都中医药大学,四川成都 610075 目的揭示川乌煎煮时间、给药剂量与毒性的相关性。方法采用均匀设计的方法,将川乌分别煎煮15 min,30 min,1 ,2 ,3 ,4 ,6 h,生药含量依次为临床用量的6,12,24,48,72,96,120倍。

The change pattern was more apparent in water decoctions than in ethanol extracts.

水煎煮单药与对药之间变化趋势尤其明显,而小檗碱的变化趋势较蒽醌类成分更明显。

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