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The weak expressions of VEGF were observed in normal retinal and blepharal tissue; while strong expressions were found in ocular malignancies.

在视网膜母细胞瘤视神经未浸润组与视神经浸润组,在眼睑基底细胞癌和鳞状细胞癌的原发组与复发组的表达之间无统计学差异(P>0.05)。

The healing rate of wound of control group is obviously higher than the model group.(3) Observe under the microscope: When 3 days after we practice the surgery, HE and observe control group wound have a large number of inflammation nature cell soak, model group wound surface inflammatory cell relatively sparse in Balb/c mouse;The control group can seeⅠtype collagenic and green type collagenic day, model group type be obviously less than the control group; When 7 days after we practice the surgery,HE and bitter acid-staining observe control group peripheral inflammation cell soak, have appeared granulation organize.

3镜下观察:创伤后第3d,HE染色观察对照组伤口有大量炎性细胞浸润,模型组小鼠创面炎症细胞较稀疏,天狼猩红染色对照组可见少量呈黄色的Ⅰ型胶原和呈绿色的Ⅲ型胶原,模型组Ⅲ型胶原要明显少于对照组;创伤后第7d, HE染色观察对照组周边炎性细胞浸润,有肉芽组织出现。

Results The main clinical manifestation of young female cervical carcinoma was abnormal colporrhagia. Surgery was made in all patients except those at the stages of Ⅲa and Ⅲb. The 5 years survival rate of 8 cases of in situ cervical carcinoma and early invasive carcinoma was 100%, and 80% in 22 cases of invasive cervical carcinoma.

结果年轻妇女宫颈癌的临床表现主要为异常阴道出血,除了对Ⅲa期、Ⅲb期及以上的宫颈癌不采用手术治疗外其他患者均经过手术治疗,8例宫颈原位癌和早期浸润癌的5年生存率为100%,22例浸润性宫颈癌的总5年生存率为80%,复发和转移率为24%。

In order to investigate the role of ICAM-1 and VCAM-1 in the pathogenesis of glomerulonephritis, ICAM-1 and VCAM-1 expression were evaluated from both protein and gene level by in vivo and in vitro study, We have conducted (1) immunocytochemical analysis and in situ hybridization to examine the alteration in expression of ICAM-1 and it's relationship with interstitial infiltrating cells and TNFα; A total of 64 renal biopsies were classified in three groups according to the degree of cellular proliferation and infiltration in glomerulus;(2) indirect immunofluoresence and immunoblotting. methods to detect the VCAM-1 level both in renal tissue and in serum from the patients of lupus nephritis (17cases) and crescentic nephritis (4 cases);(3) Cell ELISA and northern blot technique to study the effects of TNFα and IL-1β on ICAM-1 and VCAM-1 surface expression and gene expression by cultured human mesangial cells .

为了探讨ICAM-1和VCAM-1在肾小球疾病中的作用,本文从蛋白质和基因两个水平,整体(研究ICAM-1时根据肾小球内细胞增生和浸润程度,将64例病人分为A.B.C三组)和细胞培养两个方面,做了如下工作,(1)利用免疫细胞化学和原位杂交技术观察了ICAM-1在64例肾小球疾病患者中的表达及其与间质浸润细胞、TNFα之间的关系;(2)利用间接免疫荧光和膜免疫印迹方法检测了VCAM-1在17例狼疮肾炎和4例新月体肾炎病人肾组织及血清中的表达;(3)利用细胞ELISA和Northern杂交技术研究了IL-1β或TNFα对体外培养的人肾小球系膜细胞ICAM-1和/或VCAM-1表面表达及mRNA表达的调节作用。

ConclusionThe expression of α-B crystallin in IDC is significantly higher than that in DCIS and is positively related to lymph node metastasis. There are also higher levels of expression in the HER2+ and the triple-negative groups. This suggests that α-B crystallin is involved in the process of progression and metastasis of breast cancer.

结论α-B crystallin在乳腺浸润性导管癌中的表达明显高于导管原位癌,与淋巴结转移呈正相关,且在生物学行为更为恶性的HER2+组和三阴性组具有更高的表达水平,提示α-B crystallin蛋白可能参与了乳腺癌的浸润与转移过程。

MMP2 and MMP-9 play an important role in the modulation of thophoblast invasion, and their expression is difference in difference stage of first trimester pregnancy, these provided experiment basement for deeply investigation action of MMPs in the mechanism of cytotrophoblast invasion.

MMP-2和MMP-9在调节滋养细胞浸润过程中起重要作用,且在早孕不同时期,二者表达不同,为深入探讨MMPs在滋养细胞浸润机制中的作用提供理论基础。

PPARγ plays an imporlant role in the modulaltion of thophoblst invasion. PPARγ ligands can inhibit invasion through down-regulating MMP-2 and MMP-9 expressions, these provide experiment basement for deeply investigation of PPARγ ligands in the mechanism of cytotrophoblast invasion.

PPARγ在调节滋养细胞浸润过程中起重要作用,而且其作用可能是通过调节MMP-2和MMP-9的表达实现的,为深入探讨PPARγ及其配体在滋养细胞浸润机制中的作用提供实验基础。

Results:Verrucous carcinoma was classified into three groups for clinical characteristics, ectogenesis group,kystis group and infiltrating group. The carcinoma epithelium cell grew exsertum like dilatate nail. Nest of squamous cell carcinoma could be found at the former of the cancer infiltration.

结果:口腔疣状癌按临床特征可分为外生型、囊肿型、浸润型,组织学上有膨大的上皮钉突呈&推进式&生长,部分病例浸润前缘有小团鳞状细胞癌灶。

CB expression has close correlation with invasion of gastric carcinoma.The increased CB expression of vascular endotheliocyte may be helpful to the invasion and growth of tumor.

CB的表达增高与胃癌的浸润有密切关系,血管内皮细胞表达CB增多可能是促进肿瘤浸润生长的机制之一。

SHI-1 cells can be engrafted in the pretreated nu/nu mice, and this model provides a useful experimental system for the research of leukemic extramedullary infiltration.

人单核细胞白血病细胞株SHI-1能在经SCI预处理的裸鼠体内形成白血病及多器官浸润模型,可作为研究白血病及髓外浸润的一种有用工具。

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In recent years, application of the partial prestressed concrete beam s is developed.

近年来,随着部分预应力砼梁应用的推广,发现我国规范所采用的名义拉应力法的计算结果不稳定。

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