有向通路

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

Signed directed graphis a model to describe the propagation relationships among faults in large-scale complex systems, but it can just make qualitative inference along the consistent paths to isolate faults.

符号有向图是大规模复杂系统中故障传播关系的描述模型，但它仅能通过在相容通路上的定性推理进行故障分离，因此有着明显的局限性。

The experimental data demonstrated that there was a nasalward directional preference in oath OKN system under both close loop and open loop conditions, and the nasalward OKN gain evoked by stimulation of nasal retina was much higher than that at temporal retina. ms indicates that OKN nasalward preference is mairily derived from the nasal retina, i. e. the direct path1Vay of OKN dominates the indirect pathway in cat's OKN system. The gains of temporalward and nasalward OKN from temporal retina are much less than those of nasalward OKN from nasal retina. It is suggested that the indirect pathway of OKN in the cat only possesses a supplementary function, Which probably plays an important role in temporalward OKN eye-movments in relation to binocular vision.

实验结果显示：高速度刺激的闭环OKN反应及开环OKN反应均对鼻向运动刺激有明显的方向选择性；半侧视网膜刺激时，鼻侧半视网膜的鼻向OKN增益明显高于颞侧半视网膜的鼻向增益，说明猫的OKN眼动反应以跟踪鼻向运动为主，并且这种对鼻向运动刺激的选择性主要来源于鼻侧半视网膜，亦即来源于OKN直接通路；颞侧半视网膜的鼻、颞向眼动增益均明显低于鼻侧半视网膜的鼻向眼动增益，说明猫的OKN系统的间接通路在OKN眼动控制中起辅助作用，并可能主要对颞向OKN眼动起作用从而与双眼视觉功能相关。

A separate study examined the effects of bupropion, naltrexone or the combination of bupropion plus naltrexone when they were selectively administered to the ventral tegmental area, a part of the brain that is often described as the center of "the reward pathway".

另一项研究中的影响，安非他酮，纳曲酮或组合的班加纳曲酮时，他们都是有选择性地管理向腹侧被盖区，一部份的大脑常常被形容为中心的&奖赏通路&。

Chrysanthemum of 10 thousand birthday is lax to edaphic requirement, with the arenaceous qualitative loam with fecund, good drainage had better.

万寿菊对土壤要求不严，以肥沃。排水良好的砂质壤土为好。

He unstepped the mast and furled the sail and tied it.

他拔下桅杆，把帆卷起，系住。