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In order to isolate the active compounds in ethyl acetate fraction of Psoralea corylifolia L., activity-guided isolation was performed along with chromatographic techniques. Four active compounds were isolated from ethyl acetate fraction and identified by their NMR spectral data and physical-chemical properties. They are corylin and bavachin, which showed stimulating effect on osteoblastic proliferation and differentiation, isopsoralen and psoralen exhibited activity of promoting cell differentiation in some degree.

为了追踪分离补骨脂乙酸乙酯萃取物中的活性成分,本实验采用多种色谱分离技术,以活性测试为导向,结合波谱技术及理化数据,从补骨脂乙酸乙酯萃取物中分离并鉴定了4个活性化合物的化学结构,它们是具有促进细胞增殖和分化作用的补骨脂异黄酮和补骨脂二氢黄酮,对细胞分化有一定促进作用的异补骨脂素和补骨脂素。

For the purpose of exploiting the affluent resource of traditional Chinese medicines, rat pheochromocytoma PC 12 cells were used as a model to screen the neuroactive components from natural products. Most of all, the effect of it on inducing the differentiation of PC 12 cells and/or execute the neuroprotective effect challenged by serum-deprivation and oxidative pressure, and its mechanism were studied in this paper.Powered seeds of Cuscuta Chinensis Lam.

本文以利用我国丰富的天然药物资源为目的,用大鼠嗜铬神经瘤细胞PC12作为模型,筛选能模拟NGF的功能诱导PC12细胞分化、对神经细胞有一定保护作用的天然药物,并对其作用机制进行初步探索。

The dispersion of particles are also related to the interactionbetween nanosilver and polymer. Nanosilver dispersed well in PS, while form larger branchedclusters in PMMA, and polymers could prevent nanoparticles from aggregation. The interaction between nanosilver and polymers depends on the properties of polymers and treatment. XPS results indicated that no obvious interaction between nanosilver and PS was foundbefore and after heat treatment; for AS matrix, there exists a interaction between nanosilver and AN,moreover AN on the nanosilver surface could cyclize and lose N after heat treatment at 150℃ for1h; for PMMA matrix, there exists a interaction between nanosilver and O atoms, heat treatment at150℃ for 1h could lead to the reaction between Ag, S and O in the interlayer of composite andchange the interface interaction.

纳米银粒子的加入改变了聚合物体系对激光能量的吸收和转换方式,导致其激光离解方式的变化,通常此种粒子会促进聚合物的炭化,且在界面可能有诱导石墨化的作用;而银粒子自身的离解及其对基体激光离解的作用都受两相的界面相互作用的影响,即与聚合物基体的性质、后处理等有关,热处理后两相界面的变化对PS和AS体系的炭化影响不大,但PS体系中银团簇的最大原子聚集数减小;而对PMMA体系则基本上消除了激光炭化。

In addition, mRNA for the cytolytic molecules, perforin and FasL, were detected in the expanded γδ T cells, and the cytotoxicity of γδ T cells against hepatoma SMMC7721 cells was remarkably dependent on the extracellular Ca〓.

MEP激活的γδ T细胞表达穿孔素和FasL等与杀伤作用有关的效应分子,并且γδ T细胞对肝癌细胞株SMMC772l的杀伤作用有显著的〓依赖性。

Conlusions:Above results suggest: the main mechanisms of Tau preventing cytoxicity against Mn were of declining Mn-induced apoptotic effects, protecting DNA damage and declining free Ca2+ concentrtion in cytoplastic of neurons.

实验结果提示牛磺酸干预锰神经细胞毒性的机理,主要包括降低锰对神经细胞凋亡的诱导作用、对锰造成的神经细胞DNA损伤有明显的保护作用,明显降低锰造成的培养神经细胞升高的钙离子浓度。

3NE、MTT、LDH、ET-1、ICAM-1 and Tie-2experiment show: in the process of oxygen glucose deprivation/reoxygenation ,BMEC have subjected great damagement, I/R groups have significant differences compared with NC groups (p.05);polymorphonuclear leukocyte can aggregrate this injury, I/R+PMN groups have significant differences compared with I/R groups (p.05); after Sivelestat Sodium treatment, the effect of I/R injury has been decreased, I/R+PMN+Siv groups have significant differences compared with I/R+PMN groups (p.05), and NE、MTT、LDH experiment show that the three dose groups there was a significant dose-effect relationship.

3测定NE、MTT、LDH、ET-1、ICAM-1、Tie-2 mRNA均显示:氧糖剥夺/复氧复糖过程能对BMEC造成损伤,I/R组与NC组比较有明显的统计学差异(p.05);中性粒细胞能加重对BMEC的损伤,I/R组与I/R+PMN组之间比较亦有统计学差异(p.05);西维来司钠处理后,血管内皮细胞的损伤明显减轻,I/R+PMN组与I/R+PMN+SIR组比较有统计学差异(p.05),并且NE测定以及MTT、LDH实验提示在西维来司钠三个剂量组之间存在明显的量-效关系,其对BMEC的保护作用有剂量依赖性。

Compared with prozyme A, alkali enzyme was a powerful enzyme for the hydrolysis of corn protein, but it could result deamidation, that was another reason for selecting prozyme A as the first enzyme.

与复合酶A相比,碱性蛋白酶也能较好地作用于黄粉蛋白,但它对酰胺基有较强的水解作用,这是选择复合酶A作为第一次水解用酶的又一个主要原因。

A modified homogeneous flow model was introduced to calculate the flow field in RH degasser,thus getting rid of some earlier methods that are unavailable to be generalized,such as reducing the computation region or presetting the distribution of gas volume fraction.

分别对有、无旋转磁场作用时的RH系统进行了模拟计算。模拟结果表明:流场和脱碳过程与现有文献中实验结果相符合;当旋转磁场作用后,磁感应强度为0.04 T时,初期脱碳速度比无旋流作用时增加了约15%,这是由于旋流增加了系统的搅拌能,提高了脱碳反应速率。

Medicamentous liver lesion may occurred more commonly in HBsAg positive patients after antituberculous therapy.bipheny dicarboxylate and glucurolactone can only prevent and cure part of them.Drug anaphylactic reaction may play a role in medicamentous liver lesion.

HBsAg病例接受抗结核治疗易发生药物性肝损害,联苯双酯、葡醛内酯只对部分药物性肝损害有预防和治疗作用,而药物过敏反应可能在抗结核药所致药物性肝损害中起一定作用。

This is not surprising, given the closer proximity of Pengyang to the Asian inland dust sources; The average content of calcium carbonateis of Pengyang section is not only higher than that of central loess plateau, but also higher the west of Chinese Loess Plateau, which reflected Pengyang loess had been deposited by near Liupanshan\'s substances that contained more calcium carbonateis; The content of diffluent element of 10m depth in the section increased fast, which indicated that the modern eluviation and the leaching depth of loess may be stronger than our guess; The soil growth index can reflect the intensity of soil forming and the climatic changes; The "abrupt chang" of glacial and interglacial period was caused by strong soil-forming processes that enlarged the discrepancy of granularity between loess and paleosol. However, the magnetic susceptibility nearly cannot reflect the existence of S_8 and the magnetic susceptibility of S_7 is highest in the whole section, which is inconsistent with other studies that S_5 has the highest magnetic susceptibility.Thin-section examination shows that the micro-texture of the soil layers is divided into both cementing texture in S_7, S_5 and S_1, and granular texture in all others.

与其它剖面相比,彭阳剖面粒度总体上要比东部的洛川、西安,甚至西部的兰州、新疆东湾要粗;CaCO_3平均含量不仅高于黄土高原中部,也高于高原西部,反映出本剖面富含碳酸盐的六盘山近源沉积起到了很重要的作用;易溶元素含量在剖面10m处快速升高,淀积特征明显,反映出黄土受现代淋溶成土作用影响较大,黄土直立、疏松、多孔特性和高温与多雨组合的气候特点,使得元素淋溶、淀积的强度和深度超出了传统的认识和判断;烧失量与其它指标相比,不仅能区分冰期、间冰期;而且能够区分出次一级的冰阶、间冰阶,有较高的分辨率;土壤发育指数、红度能够反映土壤强度差异,是反映气候波动的较好指标;然而,磁化率不能反映古土壤S_8的存在,且S_7的磁化率在全剖面中最高,这与大多剖面S_5磁化率最高的特点不一致。4。

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Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来,英国,在此地早期居住的是凯尔特人,已经被征服了三次。

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The almost sure central limit theorem is a pop topic of the probability research in recent years,because it has many actual applications in the random analogue.

中文摘要:几乎处处中心极限定理是近几十年概率论研究的一个热门话题。它之所以引起人们的注意是由于它在随机模拟方面的实际应用参见Fisher