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Methods The amino modified wild-type and mutant probes of 16 loci ˇ1888, 3200, 3206, 3243, 3290, 3316, 3394, 3593, 3426, 12026, 12258, 14577, 14693, 14709, 16189, 16223ˇ in mitochondrial genome were immobilized onto the activated slides with aldehyde surface using Biochip Arrayer, then they were incubated overnight in a humid chamber at room temperature.

方法将氨基修饰的16个常见易感基因位点ˇ1888ˇ3200ˇ3206ˇ3243ˇ3290ˇ3316ˇ3394ˇ3593ˇ3426ˇ12026ˇ12258ˇ14577,14693ˇ14709ˇ16189ˇ16223ˇ的野生型和突变型探针ˇ通过Packard芯片点样仪点样于醛基修饰的基片上ˇ室温保湿过夜固定。

BACKGROUND: Several studies have documented a substantial genetic component in the aetiology of allergic diseases, and a number of atopy susceptibility loci have been suggested.

一些研究报道了过敏性疾病的发生与基因存在确实的相关性,而且提出了遗传过敏体质的易感基因位点。

Helicobacter pylori infection causes the defect of mismatch repair in eucaryotes, and microsatellite instability in gastric epithelial cells, which increases the spontaneous mutation of relative genes, and finally results in the susceptibility to tumors in human bodies.

H pylori 感染导致了真核细胞错配修复(mismatch repair, MMR)系统的缺陷,在胃上皮细胞中引起微卫星不稳定(micrsatellite instable, MSI),使相关基因自发突变率增加,最终可导致机体对肿瘤的易感。

The average of temporal niche breadth of mango anthracnose was 0.1177 according to disease index of leaf, while 0.2639 according to disease index of fruit.

时间生态位宽度指数分别为0.1177和0.2639,说明芒果炭疽病在时间维上的利用程度小,其发生和发展具有条件性;空间生态位宽度指数为0.7047和0.9040,病菌能够充分利用各空间资源;营养生态宽度指数为0.6662和0.5796,说明病菌可以侵染各品种,但品种间的抗病性有较明显差异,台农1号抗病性较强,红芒6号、凯特和白玉较易感病。

Polymorphism of HLA-DQB1 promoter region in Hans IDDM patients and normal controls have been identified by PCR, PCR/SSCP and PCR/sequencing methods.No differences were found in y and s box between patients and controls carrying different allele as well as in different ethnic groups. There are two different sequences in x box,but CCTAGAGACAGATT sequence locates frequently on the haplotype with DQB1.0302 allele. Polymorphism between transcription point and y box (at position -44~-46 and -59~-61) might be associated with the genetic susceptibility to IDDM. Additionally,a new single base mutant (CACC→CAC A ) was found at position -131 and -128 in two patients carrying DQB1.0601 allele.

结果显示携带不同等位基因的患者与对照者DQB1 5'-调控区y、s box核苷酸序列相同,且与白种人基因结构一致;y box核苷酸序列存在二种结构,CCTAGAGACAGATT序列常常与DQB1.0302等位基因在同一单倍型;转录起始位点至y box间-44至-61位存在多态性,-59至-61位AAG等位基因可能与1-型糖尿病易感相关联;在2例携带DQB1.0601等位基因患者的-131至-128位间发现CACC→ACA A单个碱基取代突变。

The strategy of "vaccinate those at risk" thus coincides with "vaccinate the spreaders".

因此,&为易感人群接种疫苗&的策略与&为病毒传播者接种疫苗&的提议恰巧一致。

They used a breed of laboratory rats predisposed to develop human-like heart failure.

他们用了一个品种的实验大鼠易感,以开发人力一样的心脏衰竭。

However, the frequencies of genotype 687-S, phenotype 379-II and 687-SS are significantly increased in RA patients.

TAP2 379-II、687-SS型患RA的相对危险性增加,并可能是维吾尔患者RA的易感基因。

Objective: To investigate the changes of airway resistance and specific airway conductance in asthmatic patients and the diagnostic value.

支气管哮喘是气道慢性变应性炎症,对易感者此类症状可引起不同程度的广泛的可逆性气道阻塞症状[1]。

Results We observed associations between variant alleles of multiple CISH polymorphisms and increased susceptibility to each infectious disease in each of the study populations.

研究人员最终确认了5组不同的CISH基因变异,其中一种变异(标记为-292)会使该变异基因携带者易感传染病的风险增加18%。

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