无功能的

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

The CPT values in the affected leg in patient group were significant higher than those in control group at all frequencies. The CPT values in contralateral leg in patient group were significant higher than those in control group at 5Hz whereas there were no significant differences at 250Hz and 2000Hz. The CPT values in affected leg in patient group were significant higher than those in contralateral leg at 250Hz and 2000Hz whereas there were no significant differences at 5Hz. All the CPT values showed the same linear decrease from the dermatome of the compressed root to the dermatomes of the contralateral neighbor dematom.

在用CPT监测8例腰骶单神经根病组患侧和健侧及与正常对照组的不同直径感觉神经纤维功能的研究中发现压迫皮节和其临近皮节的所有频率CPT值无任何显著性差别；患者压迫侧的2000Hz及250HzCPT值及压迫侧和对侧的5HzCPT值与正常对照组都有显著性差别；患者组5HzCPT值患侧和对侧无差别，其他两组均有显著性差别；不管有无显著性差别，神经根病患者组各皮节三频率CPT值均按照压迫皮节，临近皮节，压迫对侧皮节，压迫对侧临近皮节的顺序减小，说明在腰骶单神经根病中Aβ纤维及Aδ纤维及无髓C纤维均受累。

objective to study the anti-tumor activity and enhancing immune effect of phellinus linteus.methods the anti-tumor activity of phellinus linteus was estimated by the longevity of eac mice,the immune effect of tumorous mice was tested by the experiment of carbon particle expurgation and the il-2 concentration in serum of tumorous mice was determined by elisa.results phellinus linteus can prolong eac mouse's life and can increase the il-2 concentration in serum of tumorous mouse but can't affect the immune effect of tumorous mouse.conclusion chinese hurb phellinus linteus possess some antitumor power for tumor-loaded mice,but further research is needed.

目的 观察桑黄对肿瘤的抑制作用及对机体免疫功能的影响。方法以小鼠艾氏腹水癌的生命延长率评价桑黄的抗肿瘤作用，以炭末廓清实验观察荷瘤小鼠非特异性免疫功能，以elisa法测定荷瘤小鼠血清il-2浓度。结果桑黄对eac荷瘤小鼠的生存时间有延长作用，对荷瘤小鼠血清il-2浓度有提高作用，对荷瘤小鼠非特异性免疫功能无明显影响。结论中药桑黄对荷瘤小鼠具有一定的抗肿瘤能力，作用的强度和作用机制的深度还有待进一步研究。

left ventricle diastolic function can be reflected better by e'/a', e/a, e/e' and ivrt but there still exists localization in evaluating left ventricle relaxing function with these parameters.

e'/a'、e/a、e/e'、ivrt能较好地反映左室舒张功能，但对左室松弛功能的评价仍有局限性，应用无创的颈动脉w2评价左室舒张功能值得做更进一步的研究。

These cells are described as "nonfunctional" because they do not work like normal cells.

这些细胞不能行使正常细胞的功能，因此被称为"无功能细胞"。

Evaluate the chemo side effect after per cycle,including peripheral blood pelage, liver and renal function, alimentary canal reactions.

结果 两组化疗疗效差异无统计学意义（P〉0.05），但是，实验组患者肿瘤缩小和增大的程度均优于和低于对照组；实验组中，外周血减少和恶心呕吐发生率较对照组低（P〈0.05），两组脱发、和腹泻的发生率差异无统计学意义（P〉0.05）；两组在肝肾功能的毒性反应无明显差异。

It was suggested that aging did not only influence diastolic filling period, but also influence STI. 3. With increasing age, whether at rest or during exercice, fractional shortening of minor semiaxis, mean velocity of circumferential fiber shortening, cardiac index and ejection fraction did not change, but immediately post pacing, PEP prolonged and PEP/ LVET increased in elderly group and did not change in young group. It was suggested that STI was sensitivity in detecting systolic function of LV. 4. There was a good correlation between aging and decreased compliance and diastolic function of left ventricle which was manifested by a reduction of early diastolic peak folw velocity, time-velocity integral of early diastole, 1/3 filling fraction (1/3FF)(r=-0.958,-0.875 and -0.937, P＜0.01～0.001) and a significant compansatory increase in peak flow velocity of atrial contraction, time-velocity integral of atrial contraction, the ratio between APFV and EPFV and the ratio of ATVI and Total TVI (r=0.958, 0.956, 0.966 and 0.986, P＜0.001) and the prolongation of Dec T and RFP with increasing age. It was particularly true for the subgroups above the age of 50 years.

静息状态下收缩时间间期与年龄无相关性，负荷后即刻，老年组射血前期延长(P＜0.05)，射血前期与射血期比值加大(P＜0.05)，青年组无变化，提示年龄因素亦影响STI，但由于静息状态下得到代偿，STI变化往往表现不明显。3、静息及负荷状态左室短轴缩短率、平均周径缩短率、心指数及射血分数均不随年龄增长而变化，而负荷后即刻老年组PEF延长，PEP/LVET加大，提示STI是检测左室收缩功能的敏感指标。4、随年龄增长，心房收缩期充盈峰值流速、流速积分、充盈分数及心房收缩期与舒张早期充盈峰值流速之比值显著增高(r＝0.958、0.956、0.986及0.966，P均＜0.001)，舒张早期充盈峰值流速及流速积分、1/3充盈分数(1/3FF)下降(r＝-0.958、-0.875及-0.937，P＜0.01～0.001)。

How to make necrotic myocardial cell regeneration and diastolic myocardial function is the problem to solve.

如何使坏死心肌或无功能心肌再生，再现其舒缩功能，一直是亟待解决的难题。

Results The defects were satisfactorily reconstructed both in color and texture, with fine sensory function and no visible contracture after one year. Palpebral fissure could be closed satisfactorily. revision of skin flap were excuted after six months.

结果：皮瓣全部成活，颜色、质地与眼周皮肤相近，无明显的挛缩，皮瓣感觉功能良好，睑裂闭合良好，外观满意；皮瓣供区位于发际边缘，切口隐蔽，愈合良好，无瘢痕增生。

Further more, the simplified analysis method on stressed-skin effect of corrugated steel sheet is also discussed in detail.

此外还比较详细地探讨了蒙皮效应的简化分析方法。

If I had known her telephone number,I would have called her.

要是我知道她的电话号码，我就打电话给她了。