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Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞,导致细胞生长的抑制和凋亡罗伯托利,斯特凡Purgato ,苏埃洛卡默琳,拉菲尔Fronza ,梅奥尼博洛尼亚,西蒙娜Alboresi ,莫妮卡弗兰索尼,罗伯托Corradini ,斯特凡诺斯福尔扎,安德烈Faccini ,杰森先生Shohet , Rosangela Marchelli ,和安德烈Pession儿科,博洛尼亚大学,圣' Orsola -马尔皮基医院,博洛尼亚,意大利;有机部和工业大学化学帕尔马,帕尔马,意大利和3Center的细胞和基因治疗,德州儿童癌症中心, Baylor医学院,得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞,针对一个独特的序列反义DNA链的第2外显子,并与在MYCN 其氨基端为核定位信号肽。

While Tutshill is located in the English county of Gloucestershire, Chepstow is located in Gwent County, Wales.

不过塔特西尔坐落在英国的乡村格洛斯特郡,而查普斯托尔坐落在威尔士的格温特郡。

SB Babbage, Man in Nature and Grace; E Brunner, Man in Revolt; G Carey, I Believe in Man; S Cave, The Christian Estimate of Man; D Cairns, The Image of God in Man; W Eichrodt, Man in the OT ; WG Kummel, Man in the NT ; J Laidlaw, The Bible Doctrine of Man; JG Machen, The Christian View of Man; HD McDonald, The Christian View of Man; J Moltmann, Man; J Orr, God's Image in Man; HW Robinson, The Christian Doctrine of Man; RF Shedd, Man in Community; CR Smith, The Bible Doctrine of Man; WD Stacey, The Pauline View of Man; TF Torrance, Calvin's Doctrine of Man; CA vanPeursen, Body, Soul, Spirit; JS Wright, What Is Man?

锑巴贝奇,人在自然和恩典;电子邮件布,人在起义; G凯里,我相信人;山洞,基督教估计人; D凯恩斯,图像在上帝的人; W Eichrodt ,人在加时赛;工作组Kummel ,人在新台币; J莱德劳,圣经学说的人; JG麦,基督教观的人;高清麦当劳,基督教观的人; J莫尔特曼,男; J奥尔,上帝的形象在人;老罗宾逊,基督教学说的人;射频谢德,人在共同体;责任史密斯,圣经学说的人;的WD斯泰西,波利娜观的人;因子托兰斯,加尔文的学说的人;加利福尼亚州vanPeursen ,身体,灵魂,精神;江苏赖特,什麼是人?

In addition to Rostropovich, with whom Mr. Numajiri first performed during the New Japan Philharmonic's Shostakovich Festival, he has collaborated with other such artists as Anne-Sophie Mutter, Frank Peter Zimmermann, Zoltan Kocsis, Bruno-Leonardo Gelber, Jean-Philippe Collard, Michel Béroff, Cyprien Katsaris, Tzimon Barto, Karl Leister and Rune Kollo.

此外,他还与罗斯特罗波维奇在新日本爱乐乐团的肖斯塔科维奇音乐节同台演出,与他合作的艺术家还包括安娜-索菲·穆特、弗朗克·彼得·齐莫尔曼、佐尔坦·科西斯、布鲁诺-莱奥纳多·盖尔伯、让-菲利普科拉尔、米歇尔·贝罗夫、塞普林·加查理斯、齐蒙·巴尔托、卡尔·莱斯特尔以及鲁内·科洛。

Alice Mayhew, Elizabeth Stein, and the entire production team at Simon and Schuster were outstanding, as they always are.

爱丽斯·梅荷,伊丽莎白·斯特恩,以及西蒙和舒斯特全体团队作用显著,因为他们一直兢兢业业。

My Blythe kinfolk were descendants of both Henry III's sister Eleanor and her husband, Simon de Montfort, Earl of Leicester, who defeated the king in battle and forced him to accept the most representative parliament up to that time.

我的布莱斯宗族是亨利三世姐姐埃莉诺和丈夫莱切斯特伯爵西蒙。德蒙特福特的后裔,他在战场上打败了国王,迫使英王接受了在当时为止最有代表性的议会。

Among the 24 performances were songs by Rod Stewart, Kanye West, Joss Stone, Lily Allen and Sean "Diddy" Combs, who performed an emotive rendition of "Missing You".

整场音乐会共有24个节目,登台演唱的艺人包括罗德·斯图尔特、康恩·威斯特、乔丝·斯通、莉莉·艾伦和"吹牛老爹"西恩·康布斯等,他动情的演唱了一曲《想念你》。

Messina were plenty busy this summer signing players from across the world. Their new additions include players from Italy like Nicolas Cordova, Daniele De Vezze, Massimo Minetti, Antonio Ghomsi, Rok Straus, Edgar Alvarez and Angelo Rea. In addition to French player Lavecchia, Mark Iuliano (who was capped for Italy national football team in Euro 2000 and FIFA World Cup 2002) and last but not least Japanese player Mitsuo Ogasarawa from Kashima Antlers.

梅西纳这个夏天非常忙碌的满世界大肆挖人,他们新签球员包括科尔多瓦、德微泽、米内蒂、贡西、斯特劳斯、阿尔瓦雷斯和雷亚,除此之外还签入了法国球员拉维奇亚、尤里亚诺(参加过2000年欧锦赛和2002年世界杯的意大利国脚)还有从鹿岛鹿角加盟的前日本国脚小笠原满男。

The confusion came from the difference between the British inch and the French 'pouce', which was longer, and made Brits think Napolean was only around 5′3, a misconception which British propaganda was only happy to propagate.

爱迪生的几个设计方案已由更早的发明者提出了,包括他从亨利·伍德沃德、马修·伊凡斯、摩西·G·法马、约瑟·斯旺、詹姆斯·堡文·连特西、威廉·索亚、汉弗里·戴维和亨利·高堡购买的专利。

From General Sikorski,Admiral Darlan,Field Marshal Rommel,and King Boris of Bulgaria to Fidel Castro,Patrice Lumumba,and Salvador Allende-we learn that Hitler,the world's most unscrupulous dictator,not only never resorted to the assassination of foreign opponents but flatly forbade his Abwehr to attempt it.

这些暗杀来自西科尔斯基将军,达尔朗海军上将,隆美尔陆军元帅,还有保加利亚国王鲍里斯,我们可以列这样的名单直到菲德尔·卡斯特罗,帕特里斯·卢蒙巴,萨尔瓦多·阿连德。

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