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The slow and constant HBV infection has distinct connection with the identification, responsion and endurance of HBV antigen by human immune systems.

HBV感染的慢性化和持续感染与免疫系统对HBV抗原的识别、应答和耐受明显相关,因此HBV特异性免疫应答对决定慢性乙肝病毒感染者的病程、病理和转归有极重要的意义,是什么因素导致了机体免疫系统一系列的免疫异常进而导致对HBV感染的持续无应答状态和疾病的慢性化过程?

Compared with the previous experiment model, this model which adopts the pressure Saccule to create gradually the pressure on the cervical spinal cord has its own advantages as follows: simple to operate, safe to carry out, successful rate is higher; cheaper catheter to obtain, oppressing the machine creation the convenience; to achieve the purpose that gradually pressure on the ventral lateral spinal cord, the medical screenage and electric physical examination reflect accurately the degree of the chronic pressure on the spinal cord; the change of Pathologic histology with the impediment on spinal cord function is similar to in the characteristic changes that of human CSM. ideally simulated the pathological procedure of the gradual chronic pressure in the course of the breakout of the CSM.

与既往实验模型比较,此模型采用压力球囊法致慢性颈脊髓压迫具有以下优点:手术操作简单易行,安全性及成功率较高;导管廉价,压迫器制作方便;达到了渐进性压迫的目的;影像学及电生理检测比较准确地反映了慢性颈脊髓压迫的程度;脊髓功能障碍后脊髓病理组织学改变类似于人类脊髓型颈椎病的特征性改变;较理想地模拟CSM发病中的慢性渐进性压迫的病理过程。

Methods: The traditional method of chronic serum sickness was modified by adding followings: one kidney removed, intraperitoneal inject LPS etc., and the effect of Shenhua Tablet on 24h proteinuria, blood biochemical indices, kidney function, pathology and immunofluorescence changes was observed compared with Fosinopril, and and the effect of Shenhua Tablet on the ED-1 positive cell number in the glomerulus, protein and mRNA expression and activation of Stat3 and protein and mRNA expression of TIMP-1 in the kidney tissue, and a-SMA positive mesangial cells were observed compared with Fosinopril using western blot, northern blot and immunohistochemistry methods.

对传统的大鼠慢性血清病肾炎模型制作方法进行以下改良:切除大鼠一侧肾脏、腹腔注射大肠杆菌内毒素、以及改尾静脉注射为腹腔注射。与西药福辛普利作对照,观察中药肾华对改良慢性血清病肾炎大鼠尿蛋白、血生化、肾功能、肾脏病理变化的影响。并通过免疫组化、Western蛋白印迹及Northern杂交方法,观察中药肾华对改良慢性血清病肾炎大鼠肾组织肾小球内炎细胞浸润、Stat3蛋白与基因表达及活化、以及其下游调控的TIMP-1蛋白与基因表达、系膜细胞增殖的影响。

To Observe the Effect of Huangfengshi Serial Therapy:Fire-needle Close in Therapy for Treating Tophus;2. The fire-needle s general situation and local histopathologic change of chronic sports traumatology have been reviewed.

回顾了火针的概况、慢性运动损伤局部的组织病理学变化,从现代医学和传统医学角度初步分析了火针、激光火针治疗慢性运动损伤的机制,总结了火针和激光火针在治疗慢性运动损伤方面的应用。

Objective:in order to compare the curative effects of using lamirudine and thymosin together with using thymosin only to the paients of chronic hepatitis b.methods:we had chosen 27 medical cases of chronic hepatitis b,which were divided into two groups:15 cases asone group,and 12 cases as the other group.let group a take 100 mglamirudine orally,qd,with half a year as a period of treatment.at the same time givethe patients injections of 100 mg thymosin,qd,for a month.to group b was only takenlamirudine.alt,tbil,the indicators of the virosis of hepatitis b (hbsag,hbeag,hbv-dna)were observed as quatos.results: at the end of the treatment, the rates that groupa and group b made hbsag transform into negative were respectively 26.67% and 16.67%(p>0.05);hbeag:33.33%,8.33%;hbv-dna:53.33%,33.33%(p>0.05).conclusion:combining thymic peptide with 3tc to treat chronic type b hepatitis, thymic peptide will not only promote b-cell to mature and transformation, but also to keep the subpopulation of t-cell in immune system in balance, which can enhance the reaction of matured t-cell to the antigen or other stimulus.

目的:比较拉米夫定(3tc)与胸腺肽联用和单用拉米夫定治疗慢性乙型肝炎的疗效。方法:选择慢性乙型肝炎患者27例,分为联合组15例和拉米夫定组12例;联合组用拉米夫定100 mg,口服,qd,疗程半年,合并用胸腺肽100 mg,静滴,qd,疗程1个月。拉米夫定组单用拉米夫定。以谷丙转氨酶、血清胆红素、乙肝病毒标志物(hbsag,hbeag,hbv-dna)为观察指标,比较不同治疗方案对指标的影响。结果:治疗结束时联合组与拉米夫定组对慢性乙肝患者血清hbsag阴转率分别是26.67%和16.67%(p>0.05);hbeag阴转率分别是33.33%和8.33%(p>0.05);hbv-dna阴转率分别是53.33%和33.33%(p>0.05)。结论:胸腺肽联合3tc治疗慢乙肝,胸腺肽具有促进t淋巴细胞的成熟和转化,并维持免疫系统各t淋巴细胞亚群间的平衡作用,能增强成熟t淋巴细胞对抗原或其他刺激的反应。

Chronic gastritis is a common disease and have high incidence of a disease in china. Now, people pay much attention to the study because it is a common disease and its treatment is difficult and the state of the illness is changeable and easy carcinomatous change special chronic atrophy gastritis.

慢性胃炎是一种常见病,在我国有很高的发病率,由于慢性胃炎非常多见,它的治疗,特别是慢性萎缩性胃炎的治疗比较困难,病情反复且易发生癌变,因而对该病的研究越来越受到人们关注。

According to the appearance of the chest radiograph in chronic bronchitis, three types were classified as increased-lung-marking type, emphysematous type, and mixed type.

本文通过对210例慢性支气管炎胸部平片的X线分析,探讨了慢性支气管炎的X线表现和分型,肺心病的早期发现,以及胸部平片对诊断慢性支气管炎的评价。

Patients were randomly assigned to two groups, The one is chronic tonsillitis, the other was obstructive sleep apnea syndrome, Exclusion criteria of chronic tonsillitis included peritonsillar abscess history, bleeding disorders, and any other procedure together with tonsillectomy., Indications of chronic tonsillitis included intraoperative bleeding, operative time, postoperative pain, and return to normal diet were evaluated. Indications of obstructive sleep apnea syndrome included Intraoperative bleeding, operative time, Using spss11.0 software analyzed all the data.

实验设计和观察指标:选择慢性扁桃体炎患者30和鼾症患者30人,慢性扁桃体炎患者不包括伴随扁桃体周围脓肿患者,不包括有血液系统疾病和凝血障碍的患者,同时不包括扁桃体切除手术和其它手术同时进行的患者,鼾症患者不包括有血液系统疾病和凝血障碍患者,慢性扁桃体炎患者观察记录的指标包括手术时间﹑手术中出血量﹑术后疼痛时间和程度和正常饮食恢复时间,鼾症患者记录手术时间和手术中出血量,使用spss11.0软件对所有的数据进行描述性统计分析

Object: The project is on the basis of chronic alcoholic myopathy model of rat, to dynamically observe the change of NF-κB and MMP-2, MMP-9 in muscle cell, observe the function in the mechanism of alcohol myopathy, move forward a single step to explain the pathogenesy of this disease from gene and protein leve. We also provide a helpful platform for other metabolic myopathy. Methods:(1) 80 health, male, Sprague-Dawley rats(weight 180~200g), were chosen to sep up the CAM rat myopathy model ,to observe the rat bodyweight, the change of praxiology and the patho-change of muscle tissue.

目的:本实验旨在建立大鼠慢性酒精中毒性肌病模型的基础上,动态观察NF-κB及MMP-2、MMP-9在酒精中毒性肌病发展中的表达、变化情况,探讨其在慢性酒精中毒性肌病发病过程中的作用,从基因和蛋白水平进一步阐述该病发病机制,为慢性酒精中毒性肌病的临床防治提供理论依据,同时对于其他代谢性肌病的研究也提供一个平台。

Blocked fallopian tubes in most women are infected as a result of chronic inflammation caused by chronic inflammation as a result of fallopian tube lumen so that congestion and edema with inflammatory cell infiltration, necrosis of the cells off will lead to tubal blockage; and bilateral fallopian tube through the continuation of the endometrium is associated So, do not rule out the endometrium is also a factor in chronic inflammation; General Hospital of conventional therapy: the use of repeated hydrotubation, laparoscopy, hysteroscopy-laparoscopy joint, such as wire and interventional treatment, some hospitals every day infusion, at the same time microwave, shortwave, physiotherapy, etc.

你好!输卵管堵塞多数女性是由于慢性炎症感染所致,由于输卵管长期慢性炎症使管腔内充血水肿炎细胞浸润,脱落坏死的细胞聚集才会导致输卵管堵塞;而双侧输卵管通过子宫内膜是延续相连的,所以,不排除子宫内膜也有慢性炎症的因素;一般医院常规治疗:多采用反复通液、腹腔镜、宫腹腔镜联合、导丝及介入等治疗,也有一些医院开展每天输液,同时用微波,短波,理疗等

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