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Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病,不管是急性淋巴性白血病或是急性骨髓性白血病,在染色体11q23部位有染色体易位的情况;这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是,单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%;并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且,这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后,而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖,遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以,白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

The article uses multiple regression statistics to analyze the past settlement academic achievement, proposes a calculation method that prorates the high school entrance examination results and the results of class sorting examination organized by the school so as to provide the basis for future calculation of the settlement academic achievement, bring it closer to the real student academic level; makes full use of the historical result data of the tests that students participated, traces and analyzes the experience of our students' growth, gives full play to the advantage of small class management mode in the large classes of our school, guides students to actively summarize their own academic achievement so as to search appropriate learning methods suitable for themselves and help them develop good learning psychology quality; In addition this article uses RANK function to analyze the balance of students' terminative academic achievement, uses Radar Chart, combined with the graphic illustration of the median and hundreds' digit to analyze students' terminative academic achievement, on the one hand to guide students to focus on their overall academic development, on the other hand, to provide students with the basis for choosing arts or science subjects during entering senior two of the high school from senior one; the article provides an easy-to-operate EXCEL template to facilitate teachers to gather the information about the diagnostic academic achievement in usual schoolwork and unit tests, so that forms a timely and precise feedback link, thereby facilitating teachers to master timely the learning conditions of the students, and adjust teaching objectives and teaching strategies based on the practical situation of the students, so as to better complete the teaching tasks.

利用多元回归统计分析以往的安置性学业成绩,提出以中考成绩与学校组织分班考试按比例折算的计算方法,为今后的安置性学业成绩计算提供依据,使其更接近学生真实的学业水平;充分利用学生在校参加各次测试的历史成绩数据,跟踪分析学生的学业成长历程,充分发挥我校大班小班化管理模式优势,指导学生对自我学业成就进行积极归因,寻找适合自己的学习方法,从而帮助学生形成良好的学习心理品质;利用RANK函数分析学生终结性学业成绩的均衡性,利用雷达图,结合中位数和百位数图示化分析学生终结性学业成绩,一方面引导学生关注自身全面的学业发展,另一方面,为学生在高一升高二文理分科时提供选择依据;提供操作简单的EXCEL模板,方便教师收集平时作业或单元测验中的诊断性学业成绩信息,使教学反馈环节及时精细,有利于任课教师及时了解学生的学习状况,根据学生实际情况调整教学目标和教学策略,从而更好地完成教学任务。

The use of multiple regression statistical analysis of past resettlement of academic achievement, proposed to the examination results and school organizational placement tests prorating method of calculation for the future provide the basis for placement of academic computing, bring it closer to the real student academic level; make full use of students in school to participate in the history of the various test results data, follow-up analysis of our students grew up, give full play to our school-based management advantages of large classes in small classes, guiding students in active academic achievement of self-attribution, searching for their own learning methods to help students develop good study of psychological quality; use RANK function analysis of the end of the academic results of students balanced, using radar chart, combined with the median shows the median and the Analysis of 100 students in the end of academic performance, on the one hand to guide students to focus on their overall academic development, and on the other hand, for students in high-rise 2 1 Division of Arts and to provide selected on the basis; to provide easy-to-EXCEL template to enable teachers to gather in peacetime operations or unit tests in the diagnosis of academic information, so that the teaching timely and detailed feedback loops are conducive to Teacher students to keep abreast of the situation, according to the actual situation of students to adjust teaching objectives and teaching strategies in order to better complete the teaching tasks.

利用多元回归统计分析以往的安置性学业成绩,提出以中考成绩与学校组织分班考试按比例折算的计算方法,为今后的安置性学业成绩计算提供依据,使其更接近学生真实的学业水平;充分利用学生在校参加各次测试的历史成绩数据,跟踪分析学生的学业成长历程,充分发挥我校大班小班化管理模式优势,指导学生对自我学业成就进行积极归因,寻找适合自己的学习方法,从而帮助学生形成良好的学习心理品质;利用RANK函数分析学生终结性学业成绩的均衡性,利用雷达图,结合中位数和百位数图示化分析学生终结性学业成绩,一方面引导学生关注自身全面的学业发展,另一方面,为学生在高一升高二文理分科时提供选择依据;提供操作简单的EXCEL模板,方便教师收集平时作业或单元测验中的诊断性学业成绩信息,使教学反馈环节及时精细,有利于任课教师及时了解学生的学习状况,根据学生实际情况调整教学目标和教学策略,从而更好地完成教学任务。

The investigation result shows: The in the period of society transition, the need that the meaning system changes is a social reason why an individual is converted to the religion; person is exposed to the religion under the circumstances that the external utility motive is driven at first, but as time goes on, the composition of the spiritual aspect increases gradually in its faith; The religious belief reinvents the individuals ethics moral concept and social behavior, have produced certain positive effect objectively.

调查结果表明:社会转型时期,意义系统转换的需要,是个体皈依宗教的社会原因;信仰者最初是在外在的功利性的动机驱动下接触宗教的,但随着时间的推移,其信仰中精神层面的成分逐渐增加;宗教信仰在一定程度上重塑了教徒的价值体系,导致其社会行为的信仰归因,但客观上也产生了一定的积极的效应。

The existence ofpolar nanoregions dramatically influences the extrinsic dielectric nonlinearityof paraelectric phase. 5 Slow relaxations of field induced piezoelectricresonance of paraelectric barium stannate titanate were observed after eitherapplying or removing a DC bias field. This phenomenon is attributed to slowspace charge dipoles formed by injected homocharges and validated by theobservation of a negative piezoelectric constant. Isothermal study ondielectric constant and discharging current after application or removal of astep field were performed. The relaxation laws in ferroelectric andparaelectric phases are different. The transportation of homocharges arebelieved to be responsible for the strong relaxation behavior in paraelectricphase. Domain wall can trap space charges thus the relaxation in ferroelectricphase is relatively weak. Abnormal phenomena, such as slim-waisted hysteresisloops, abnormal C-V curves and clockwise reversible hysteresis loops observedin barium stannate titanate ceramics, were attributed to pinning of gatheredpoint defect on domain walls.

5研究了直流电场施加和撤除引起的钛锡酸钡顺电相场诱压电谐振慢弛豫现象,认为这是同极性空间电荷注入形成空间电荷慢偶极子导致的,观察到的负压电常数证实了这个观点;研究了等温条件下阶跃电压作用下介电常数和放电电流的慢弛豫现象,发现钛锡酸钡陶瓷的铁电相和顺电相呈现不同的宏观性能时间依赖规律,认为是同极性空间电荷的输运过程导致了顺电相样品呈现强的弛豫行为,铁电相中存在畴壁捕获空间电荷的机制因而其弛豫行为较弱;研究了钛锡酸钡陶瓷中束腰电滞回线、反常 C-V 曲线和顺时针可逆电滞回线等反常现象,将其归因于点缺陷的聚集对铁电畴畴壁的钉扎作用,多次电场循环有助于解除这种钉扎状态,减弱反常特征。

Then we study investors\' behavour in China by using the questionnaire method from three dimensions—investor\'s knowledge,psychology and behavior and from seven affecting factors—motive,securities investment Knowledge,awareness of risk,investment philosophy,trading,investment decision-making rule and investment performance.Aiming at these investment characteristics we examines the conservative bias and the reasons for the deviation from mental deviation from the emotional,social psychology and cognitive psychology deviation and from over-confidence,loss aversion,conservatism aversion, excessive fear of selective bias,selecting aversion,gambling psychology,self-attribution,the dependence on the policy bias and rapid money-making psychology.And we analyze investors\' several restrictive conditions during investment decision-making including information and knowledge constraints,psychological constraints,funds constraints and external conditions.

本文从全球股灾的教训及近年来我国证券投资者生存现状出发,从理论和实践两个角度论述了加强投资者教育以提高我国投资者在投资过程中的自我保护能力的重要性;采用调查问卷的方法,从投资者的知识、心理、行为三个构面,从入市动机、证券投资知识、风险意识、投资理念、交易行为、投资决策依据及投资业绩等七个影响因素来考察了我国投资者的投资行为;针对这些投资者的行为特征,从情感心理偏差、社会心理偏差和认知心理偏差三个构面,从过度自信、损失厌恶、保守性偏差、过度恐惧、选择性偏差、赌博心理与自我归因、对政策的依赖性偏差以及暴富心理等影响因素出发对我国投资者的认知偏差,以及产生这些偏差的原因进行了分析,探讨了投资者在投资决策时的几个约束条件,即信息约束、知识约束、心理约束、资金约束以及外部条件约束。

Drawing upon recent finds, the archaeologist Cheryl Ward sets out to recreate the voyage, in a full-size replica of one of these ancient ships, sailing it in the wake of Hatshepsut's fleet, in search of the mythical land of Punt.

这是让人纠结又困扰的新概念,与通常的直觉相背。 Jim教授揭示出大自然的美丽和结构中隐藏的科学规律,而不是将其归因于神奇或者上帝的力量。它是物理定律的固有的组成。神奇的是,混沌中的数学可以解释宇宙中优美的斑图和有序是如何产生,为什么产生的。

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Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来,英国,在此地早期居住的是凯尔特人,已经被征服了三次。

Bluetooth OBEX File Transfer Enables the sending and receiving of files on your phone via Bluetooth.

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The almost sure central limit theorem is a pop topic of the probability research in recent years,because it has many actual applications in the random analogue.

中文摘要:几乎处处中心极限定理是近几十年概率论研究的一个热门话题。它之所以引起人们的注意是由于它在随机模拟方面的实际应用参见Fisher