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CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体,是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成,即t(9;22),使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端,形成异常的bcr-abl嵌合基因,该基因转导出异常的mRNA,编码并翻译出P210蛋白,该蛋白具有很强的酪氨酸激酶活性,使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株,具有Ph染色体。

Much oxygen was evolved in the course of H〓 production. Sodium dithionate and DCMU make the system anaerobic, but H〓 production didn't increase, even decreased. By addition of sodium acetate, glucose, heteroauxing in the course of illumination and Fe, Ni in the course of algal growth, the H〓 production increases by P.

采用强还原剂、PSⅡ抑制剂虽然可使体系处于厌氧状态,但产氢效率并无提高,甚至下降;光照产氢过程分别外加碳源NaAc、促生长剂IAA,藻体培养过程中补充Fe和Ni的无机物均能使扁藻产氢的效率有所提高。

Greenhorns write of syncopation now as if it were a new way of giving the utmost impetus to a musical measure; but the rowdiest jazz sounds like the Maiden's Prayer after Beethoven's third Leonora overture; and certainly no negro corobbery that I ever heard could inspire the blackest dancer with such diable au corps as the last movement of the Seventh Symphony. And no other composer has ever melted his hearers into complete sentimentality by the tender beauty of his music, and then suddenly turned on them and mocked them with derisive trumpet blasts for being such fools.

毛头小伙子们现在一提起切分音就好象是一种使音乐节奏成为最强而有力的新方法;但是在听过第三里昂诺拉前奏曲之后,最狂热的爵士乐听起来也象&少女的祈祷&那样温和了,可以肯定地说我听过的任何黑人的集体狂欢都不会象贝多芬的第七交响乐最后的乐章那样可以引起最黑最黑的舞蹈家拼了命地跳下去,而也没有另外哪一个作曲家可以先以他的乐曲的阴柔之美使得听众完全溶化在缠绵悱恻的境界里,而后突然以铜号的猛烈声音吹向他们;带着嘲讽似地使他们觉得自己是真傻。

Results In define induction envioroment, HPMSCS can diferentiate into lipoblast、after 2 weeks, the induced cells are full of lipid droplet;HPMSCS can differentiate into osteoblasts, after 4 weeks, we can see calcified tubercle in the cells, calcium in the calcified tubercle can be dyed black by Von Kossa and ALP dying is positive reaction above 95%.

结果 HPMSCS在培养基中持续培养后,在特定诱导环境下,成功使其向成脂肪细胞转化,培养2周时,可见融合成团的脂滴充满整个细胞;成功使其向成骨细胞转化,培养4周以上可见明显钙化结节,von Kossa染色可将骨结节中沉积的钙染成黑色,碱性磷酸酶染色呈强阳性反应达到95%以上。

In order to reach the designed target of myoelectric hand,two keys must be emphasized: one is to look for the strongest myoelectric signal of the residual and the other is to continuously enhance the feedback training process, which coordinates vision with myoelectric hand.

欲使肌电手达到预期设定的目标,训练有两个关键:一是寻找残肢肌肉的最强肌电信号;二是不断强化生物反馈过程,使视觉和肌电手的动作协调自如。

The photochemical smog characteristic is the outward appearance usually assumes the blue color, has the strong oxidability, can cause the rubber dehiscence, stimulates the people eye, the injury plant leaf, and causes the atmospheric visibility to reduce.

光化学烟雾的特征是外观通常呈蓝色,具有强氧化性,能使橡胶开裂,刺激人们眼睛,伤害植物叶子,并使大气能见度降低。

Based on the dyanamic analysis of position loop system for the use of four roll hydraulic mill, analyses of thickness precontrol and monitored control function and constitutent are given; and the design procedure of a digital controller and specific plan of microcomputer implementetion are also given.

在四辊液压轧机位置闭环系统动态分析的基础上,分析厚度预控和监控的功能、组成数字控制器的设计方法,以及微机实现的具体方案。将其应用到Φ(2 1 0~ 5 0 0 )mm× 80 0mm四辊液压轧机上,使轧机具有较强的消差能力,并使出口带材能锁定在要求的目标尺寸上

Motor controlling, the magneto-electric and red glare stimulus exists a strong inverse relation between prestimulus oscillations and brain responses.

神经电位从无序到有序状态的转换中,多而强的感觉刺激使大脑成为更好的协调并使脑神经电活动具有空间分布性但时间上同步性的状态。

We had designed and produced the por-table ophthalmic operating microscope whichis compact in constraction, light in weight(19kg only) and convenient in carrying, excel-lent in optical quality, strong in stereognosis,wide in visual fie1d, low in price, and rotable in360 round, hence this kind of operating micro-scope is benefit in popularization ofophthalmic microsurgery and increase of therate of success of ocular operation in basic-level hospitals.

立体感;成功率;光学质量;眼科;人工晶体;青光眼手术;轻便式;手术显微镜;显微手术;放射状切开;我们设计并生产了轻便式眼科手术显微镜,这种显微镜体积小,重量轻(仅19kg),一人即可携带,而且光学质量高,立体感强,视场大,可做360°范围旋转,价格低廉。这样可以尽快使显微手术在国内普及提高手术成功率,使数以万计的眼病患者都能在当地得到良好的治疗。

The results showed that in the growth period of R. glutinosa, soil ferulic acid, vanillic acid, and vanillin contents had a persistent increase, while β-hydroxybenzoic acid content increased first but decreased then. The addition of ferulic acid (8 μg·ml-1), vanillic acid (08 μg·ml-1), vanillin (12 μg·ml-1), and β-hydroxybenzoic acid (30 μg·ml-1) in water culture had stronger inhibitory effects on R. glutinosa root length, root mass, fresh plant mass, and plant height. Treating with test phenolic acids except β-hydroxybenzoic acid increased leaf chlorophyll content significantly, compared with the control. After treated with test phenolic acids, plant SOD and POD activities decreased after an initial increase, and plant malondialdehyde content increased. In the treatment of ferulic acid, root SOD and POD activities were the lowest, and roots were rotted and dead.

结果表明:阿魏酸、香草酸和香草醛含量在地黄生长期表现为持续增加,而对羟基苯甲酸含量先升高后降低;外加阿魏酸(8 μg·ml-1)、香草酸(0.8 μg·ml-1)、香草醛(1.2 μg·ml-1)和对羟基苯甲酸(3.0 μg·ml-1)对水培地黄根长、根质量、全株鲜质量和株高有较强的抑制作用;酚酸处理使地黄叶片叶绿素含量降低,除对羟基苯甲酸外差异性极显著;经过酚酸处理的地黄幼苗SOD和POD活性为先升高后下降,丙二醛含量升高,其中阿魏酸的处理使根中酶活性降至最低,根部腐烂死亡。

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