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Result The conditions for GC-MS of Rhizoma Ligusticum chuanxiong and the characteristic fingerprint was established. The components of chuanxiong's ether extract were analyzed.

结果:确定了气质联用分析条件,分析了川芎乙醚提取液的化学成分,建立了川芎的特征指纹图谱。

Objective: To establish an HPLC method for the Determination of ligustrazine hydrochloride in its injection.

目的:建立高效液相色谱法测定盐酸川芎嗪注射液中盐酸川芎嗪含量的方法。

ConclusionThe content of ferulic acid is increased by Szechwan Lovage Rhizome and reduced by Liquorice Root, Szechwan Lovage Rhizome and Peach Seed, Szechwan Lovage Rhizome and Liquorice Root.

结论生化汤中川芎明显增加生化汤中阿魏酸的溶出量,甘草及川芎和桃仁、川芎和甘草的两两交互效应可显著降低阿魏酸的含量。

Results: Ligustrazine bisphenylmethyl piperazine derivatives showed protective effects on ECV-304 cells injured by hydrogen peroxide, which were more effective than Ligustrazine.

结果:川芎嗪二苯甲基哌嗪衍生物具有对ECV-304细胞氧化损伤的保护作用,其活性比川芎嗪强。

Objective To evaluate heat shock protein 72 (HSP72) mRNA expression in myocardium of non cyanotic patients of congenital heart disease during cardiopulmonary bypass surgery for correction of congenital heart disease, to investigate if tetramethylpyrazine pre-conditioning can modify the expression of HSP72 during CPB ,and if TMP pre-conditioning can attenuate CPB-induced myocardial ischemia reperfusion injury through a self-protective mechanism.

目的:研究体外循环前后非发绀型先天性心脏病矫治术患者心肌组织中热休克蛋白72(HSP72)的表达和川芎嗪预处理对其表达的影响,并探讨川芎嗪预处理的心肌保护机制。

The chemical structure of Ligustrazine is tetramethyl pyrazine, its four methyl can show different efficiency, when they are replaced by different functional units.

川芎嗪化学结构为四甲基吡嗪,其四个甲基被不同的功能基因替代后可产生不同效应,研究发现川芎嗪对心血管系统的作用有多种不同的作用途径和作用机制。

All rats were randomly divided into tetra methyl pyrazine injection, Shexiang baoxin pills model group and sham operation group.

结果:模型组、麝香保心丸组及川芎嗪组大鼠MI边缘区MVC和MVD较假手术组明显增多(P〈0.05);川芎嗪组大鼠缺血心肌MVC和MVD较模刑组明显增加(P〈0.05)。

The uv detection wavelength was 240 nm, column temperature was 20℃. resultsan hplc fingerprint for chuanxiong dispensing granules was established both fidelity and reparability were good. it had 11 common peaks.

结果得到分离度、重复性均较好的川芎配方颗粒hplc指纹图谱,标示了11个共有峰,对10批川芎配方颗粒hplc指纹图谱进行相似度评价,并与川芎饮片hplc指纹图谱进行比较研究。

OBJECTIVE to compare formula granule with decoction pieces stand ard broth of chuanxiong and liquored chuanxiong in pharmacodynamics equivalence.

目的 比较川芎配方颗粒与川弯饮片标准汤剂、酒川芎配方颗粒与酒川芎饮片标准汤剂是否具有药理等效性。

METHODS Mice hot-plate, writhing test and mice menalgia model of acute stress blood stasis rat was used to compare therapeutic action of the three preparations RESULTS Both chuanxiong formula granule and decoction pieces standard broth of liquored Chuanxiong formula granule and decoction pieces stand ard broth could prolong pain threshold, extend incubation period caused by acetic acid andoxytocin, reduce writhing frequency, and improve some indexes of hemoreology in acute stress blood stasis rat.

选择热板法、扭体法、痛经模型、急性应激血淤血液流变性等方法,比较川芎配方颗粒及饮片、酒川芎配方颗粒及饮片的主要药理作用。结果川芎配方颗粒与川芎饮片标准汤剂、酒川芎配方颗粒与酒川芎饮片标准汤剂均能延长小鼠热板痛闭值,均能延长醋酸所致扭体反应的小鼠扭体潜伏期并减少扭体次数,均能延长小鼠痛经模型中催产素所致扭体反应的潜伏期并减少扭体次数,均具有改善急性应激血淤大鼠血液流变的作用。

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