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尼古丁酸

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A reversed phase ion-pair high performance liquid chromatographic method was developed for the simultaneous determination of nicotine and cotinine in human hair.

以庚烷磺酸钠为离子对试剂,建立了同时测定头发中尼古丁和可天宁含量的反相离子对高效液相色谱方法。

Given the known reaction mechanism and general chemical considerations, we propose that nicotine, when used as the carbon source by P. putida J5, is catabolized to pyruvic acid via pyrrolidine pathway and then participates in the synthesis of vitamin pantothenate and CoA, which supply the energy for the normal functioning.

通过对突变位点基因的功能分析推测,假单胞杆菌可以将尼古丁代谢为2,5-二羟基吡啶,而2,5-二羟基吡啶可以进一步转化为丁烯二酸和丙酮酸,进而参与了泛酸和 CoA 的合成,为生理代谢提供基质。

Clinicians should be able to recognize and treat significant toxidromes resulting from acetaminophen; anticholinergic agents including antihistamines and psychoactive drugs; anticoagulants such as warfarin or rat poison; cardiac medications including calcium channel blockers, beta-blockers, and digoxin; muscarinic cholinergic agents including carbamates, some mushrooms, and organophosphates; nicotinic cholinergic agents such as insecticides and nicotine; cyanide; ethylene glycol or methanol from antifreeze or rubbing alcohol; iron-containing products such as deferoxamine; opioids such as morphine, hydrocodone, or methadone; salicylate (aspirin-containing products); sulfonylurea; and sympathomimetic agents such as amphetamines, caffeine, cocaine, or ephedrine.

医师必须可以辨识与治疗乙醯胺酚;抗胆碱剂,如抗组织胺与精神作用药物;抗凝血剂,如warfarin或杀鼠剂;钙离子阻断剂、乙型阻断剂、毛地黄等心脏药物;蕈毒胆碱剂,如氨基甲酸酯盐、某些有毒蘑菇、有机磷农药;菸碱性胆碱剂,如杀虫剂与尼古丁;氰化物;抗冻剂或外用酒精的乙二醇或者甲醇;含铁产品,如 deferoxamine;鸦片类,如吗啡、hydrocodone、美沙冬;水阳酸;硫醯基尿素类降血糖药;拟交感神经药物,如安非他命、咖啡因、古柯碱或麻黄素等造成的明显中毒症候群。

The measurement of nicotine and its major metabolites cotinine and trans-3 -hydroxicotinine together with other minor metabolites (e.g., cotinine N-oxide, cotinine, and trans-3 -hydroxicotinine glucuronides) in conventional and nonconventional biological matrices has been used as a biomarker to assess the exposure to environmental tobacco smoke during childhood.

常规和非常规性生物基质内尼古丁、尼古丁主要代谢产物可替宁和反式-3-羟基可替宁及其他代谢产物(可替宁N-氧化物,可替宁和反式-3 –羟基可替宁葡萄糖苷酸)的检测可作为评价儿童期环境烟草烟雾暴露的一个生物标志物。

A series of PVC membrane electrodes with nicotine containing different plasticizeres such as octyl phthalate, nonyl phthalate and di octyl dicaproate, and electric active substances such as association of nicotine-tetraphenyl borane, nicotine-silicotungstic acid, nicotine-phospho-wolframic acid and nicotine-Reineckate ammonium were prepared.

以尼古丁为研究对象,研制了一系列含有不同增塑剂(苯二甲酸二辛酯、苯二甲酸二壬酯和癸二酸二辛酯)和电活性物质(尼古丁四苯硼缔合物、尼古丁硅钨酸缔合物、尼古丁磷钨酸缔合物和尼古丁雷氏盐缔合物)的PVC膜电极。

The metabolite of nicotine-cotinine in urine was assayed by means of barbituric acid. Cotinine was used as an objective indicator to reflect the smoking quantity. The urinary NO (NO-2) was determined with colorimetric estimation.

用硫代巴比妥酸法测定吸烟者尿液中尼古丁代谢产物-柯替宁作为吸烟量的客观指标,用分光比色法测定尿中NO含量,来反映体内NO水平。

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