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The raw data was processed by using axial, coronal and double oblique multi-planar reformation; Images obtained were graded in terms of quality with a 5-point scale(5=excellent, 4=good, 3=fair, 2=poor, and 1=nondiagnostic). In grading image quality at axial MPR, The radiologic specialists focused on the subarcuate fossa, tendon of tensor tympani, facial recess, vestibular aqueduct and pyramidal eminence, In grading image quality at coronal MPR, attention was given to the scute, crista transversa, fenestra cochleae, lateral malleal ligament and snake eyes signature of cranial nerve, In the grading of the image quality at double oblique MPR, the radiologic specialists concentrated on the malleus, incus, stirrup bone, upper bony semicircular and aquaeductus fallopii, and then to implement statistical analysis. In order to choose the minimum tube current values and the maximum pitch that can satisfy the diagnosis request, image quality of axial, coronal and double oblique reformation images was compared with different tube current groups. 15 ears of volunteers were used to test the validity with the scanning parameter. Subsequently noise, MTF and dose length product were measured by phantoms in different tube current and pitch, the parameters obtained were compared and taken into statistics analysis.

扫描模式使用临床常用的颞骨螺旋扫描方式:管电压120 kV,准直宽度20×0.6 mm,视野200 mm,重建矩阵512×512,旋转时间1 s/r,重建层厚0.6 mm,重建间隔0.3 mm,分别改变管电流(380、300、200、160、120和80 mA)和螺距(0.8、1.0和1.2)进行扫描和重建,然后对颞骨进行横断面、冠状面和双斜面多平面重组,于重组后的横断层面图像上选取弓形下窝、鼓膜张肌腱、面神经隐窝、前庭导水管和锥隆起5个解剖结构,冠状面重组图像上选取盾板、横嵴、蜗窗、面神经的蛇眼征和锤骨外侧韧带5个解剖结构,双斜面重组图像上选取锤骨、砧骨、镫骨、上骨半规管和面神经管5个解剖结构,在双盲的情况下由放射学专家分别对各管电流和螺距下扫描的重组图像进行评分,随后进行统计学处理,从中筛选出满足诊断要求的最低管电流值和最大的螺距,分别采用患者25例(15耳)用该管电流值和螺距验证其可行性;然后利用模体分别测试各管电流和螺距下的图像的空间分辨率、噪声及其剂量长度积,并对测试所得参数数值进行比较和统计学处理。

Implantation of autologous ilium and titanium-net cancellated bone were widely used on clinic, and both of them had an excellent fusion ratio.

目前临床上应用的植入物以自体髂骨和钛网松质骨植骨多见,取得了良好的植骨融合率。

2Cm bone defect was established in ulna of rabbits, the capacity of different therapeutic measures in bone defect repairment was determined in groups A , B (implanted BMP, TGF -β〓 and carrier) and C . It was found that the appearance of osteoblasts and formation of bone union were earlier and the number of osteoblasts more in group B than in group A. The amino acid analysis revealed that the volume of ossein was significantly higher in group B than in group A at the early stage.

分别用bBMP及载体bBMP、TGF-〓及载体和单纯载体修复兔尺骨1.2cm骨缺损的实验模型来比较三者间的成骨效果,结果表明B组比A组成骨细胞出现早、形成数量多、骨连接形成提前,骨胶原氨基酸分析在骨缺损修复早期胶原形成量B组均高于A组,且B组以形成Ⅰ型胶原为主,C组表现为一纤维形成过程。

Mandibular symphysis for bone block grafts is a good donor site which provides larger bone volume and contains more cancellous bone.

下颚骨联合区用作块状骨移植可以取得较大的骨量,以及较多的海绵质骨。

AOPA, by "multiple relevant convergence reaction", adjusts and affects systematically the endocrinal function of bone metabolism,improves the levels of estrogen and CT/PTH, reverses the declining tendency of pituitary-thyroid axis function and improves thyroid function so as to weaken osteocyte in the bony absorption, enhance osteoblast in osteogenesis and increase bone density.

AOAP可以通过&多位点相关集合效应&综合调控影响骨代谢的内分泌功能,提高雌激素、降钙素/甲状旁腺素水平,扭转垂体-甲状腺轴功能减退的趋势,改善甲状腺的功能,使破骨细胞的骨吸收减弱,成骨细胞的骨形成增强,增加骨密度。

Microscope examination:in group a,at 2 weeks,a few inflamatory cells appeared in the holes with many osteoblasts and ostoid appeared around the drilled holes.at 8 weeks,marrow formed in the drilled holes in group b,at 2 weeks,there were a large amount of osteoblasts in the drilled holes and some ostoid formed around thc drilled holes.at 4 weeks,the drilled holes were full of trabeculae.at 8 weeks,the trabeculae matured with the marrow appeared in the intertrabecular space.

组织学结果:2周时a组钻孔区出现少许炎症细胞,边缘出现较多成骨细胞并有骨组织形成,至8周时,钻孔区内形成骨髓组织,只在边缘形成骨小梁结构。2周时b组钻孔区有大量的成骨细胞,边缘有较多骨组织形成,4周时钻孔区内充满新生骨小梁结构,8周时钻孔区内骨小梁成熟,小梁有骨髓组织填充。[结论]骨髓基质干细胞对兔股骨头缺血性坏死有良好的修复作用。

Focus on research work and clinical studies in musculoskeletal oncology, especially about mechanism and biological therapy of osteosarcoma, such as proteomics studies of osteosarcoma, prospective control study of osteosarcoma, registration system of musculoskeletal oncology and genic tests about the familial inheritance osteoenchondroma, etc.

拟开展《骨肉瘤特异性相关抗原的蛋白质组学研究》、《骨肉瘤多中心前瞻性随机对照研究》、《骨与软组织肿瘤注册-会诊-随访登记系统》、《多发性骨软骨瘤家族遗传性基因的检测》等课题的相关研究工作,承担国家、省级和市级重大项目等课题的申报。

In the period of 8 to 16 weeks after operation,new bone was formed continuously, artificial bone gradually reconstructed to mature lamellar bone,bone trabeculae and medullary cavity,etc. Conclusion The preparation of CPC is simple.

结果 CPC植入后4周有新生软骨形成及未成熟的骨组织,可见大量的软骨细胞、成骨细胞、胶原组织及较多的小血管。8~16周新骨继续生成,人工骨逐渐改建为成熟的板层骨、骨小梁和髓腔结构。

Results There existed new cartilage and new immature bone tissue in the bone substitute in 4 weeks after operation, as well as mass of cartilageous cells,osteoblasts, collagen tissue and more small vessels were seen. In the period of 8 to 16 weeks after operation,new bone was formed continuously, artificial bone gradually reconstructed to mature lamellar bone,bone trabeculae and medullary cavity,etc.

结果 CPC植入后4周有新生软骨形成及未成熟的骨组织,可见大量的软骨细胞、成骨细胞、胶原组织及较多的小血管。8~16周新骨继续生成,人工骨逐渐改建为成熟的板层骨、骨小梁和髓腔结构。

METHODS: 5 g CPC was dissolved in 2 mL water, and then 0.1 g Doxorubicin microspheres was incorporated into the powder-phase CPC. The column microsphere bone cement was prepared at a diameter of 0.18 cm and a height of 1.12 cm. While untreated CPC was taken as blank control and Doxorubicin control was also prepared.

将2 mL水加入5 g骨水泥粉中,然后迅速将干燥的0.1 g多柔比星微球加入其中,搅拌均匀成糊状后推入预制磨具中制备成直径0.18 cm,高1.12 cm的柱状载微球骨水泥,两断端平行,打磨光滑平整,同时制备不载多柔比星的空白对照组、多柔比星原药对照组。

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