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Then the effects of p16 on replicative cellular senescence of 2BS cells were examined.

目的探讨细胞周期抑制因子p16在细胞衰老中的作用。

The identified proteins are involved in a variety of cellular process including several zinc finger proteins relevant to transcription regulation, such as zinc finger 198, 263, 14, 224, zf6, novel protein similar to transcriptional represser CTCF, and kruppel-like zinc finger protein; two members of the ADAMs (a disintegrin and metalloprotease domain) family; two members of integrin family; several proteins involved in the signal transduction, cell-cycle control, chromatin remodeling and transcription repression; and also some proteins of cell skeleton and some with unknown functions.

鉴定出 的蛋白包括多个与转录调控相关的锌指蛋白,如锌指蛋白198、263、14、224、zf6、转录抑制因子cTcF样蛋白、幻肚pple样锌指蛋白等:两个含金属蛋白酶结构域和整合素结合结构域的家族成员ADAM28和ADAM17;两个整合素家族成员pZ整合素和含十个EGF样结构域的整合素;与细胞信号转导通路有关的蛋白;与细胞周期调控有关的蛋白;与染色体重塑和基因转录抑制有关的蛋白;细胞骨架蛋白以及其他功能未明的蛋白等。

In this paper the authors report on the biological characteristics of Al-sophila spinulosa Hook.

孢子—原叶体—孢子体的生活周期长,并且在丝状体、原叶体和幼孢子体阶段,无特殊结构去抵抗和忍耐一切不利环境因子的影响。3。

The article focuses on the aberrant expression and significances of proto-oncogenes, tumor suppressor genes and genes associated with the proliferation process of gastric cells such as telomerase, transcription factor and cyclooxygenase, etc. These genes, alone or synergically, participate in gastric cancer cell proliferation, resulting in an uncontrolled growth characterized by over-proliferation of decreased apoptosis of gastric cancer cells.

本文着重阐述了与胃癌细胞增殖过程密切相关的端粒酶、核转录因子、环氧化酶等基因以及参与细胞周期调控的原癌基因、抑癌基因的异常表达及临床意义,这些基因或单独作用,或相互协同,参与胃癌细胞的增殖,使肿瘤细胞生长以增殖过多、凋亡过少的失控性生长为特征。

Moreover, we studied the regulation of Cyclin E-Cdk2 on the protein expression and transcriptional activity of pufferfish STAT proteins.

而本论文进一步作细胞周期蛋白Cyclin E-Cdk2复合体调控STAT转录因子之蛋白质表现与转录活性之研究。

This paper,to more complicated stock product,makes use of martingale measure and the method of stochastic analyse,gives the mult-factor pricing model of convertible bonds with redeemable clauses ,combines the actual circumstance of market disburses dividends,discusses the martingale pricing of n-factor convertible bonds with periodic dividends,and induces the pricing formula.

针对较为复杂的股票产品,利用鞅测度和随机分析的方法给出了附有回购条款的可转换债券多因素定价模型,并结合市场分红的实际情况,探讨了在周期付红利下n-因子可转换债券的鞅定价,且给出了价格公式

Objective To investigate whether cell uncoupling could be induced by mitomycin C.

目的:观察DNA损伤因子丝裂霉素能否诱导细胞周期解偶联。

Objective To study the effect of the expression of cell cycle regulators on the development and prognosis of colorectal carcinoma.

目的 探讨细胞周期调控因子蛋白表达在大肠癌发生发展中的作用及其对预后影响。

the possible mechanism of antiaging effect of fructus corni polysaccharides is to regulate the expression of cyclind1 and cdk4 in hdf senescence model cell.

山茱萸多糖可能通过改变细胞周期调控因子的表达而发挥其抗hdf细胞衰老作用。山茱萸多糖;cyclind1;cdk4;人二倍体成纤维细胞

The eukaryotic translation initiation factor 5A (eIF-5A) is a small acidic protein (18k Da), widely presents in all organisms from archebacteria to mammals but not in eubacteria, with highly conserved sequences. eIF5A is unique in that it is the only protein known to contain the unusual amino acid residue hypusine (hydroxyputrescine-lysine), which is essential for eIF5A function and is formed by post-translational modification of a specific lysine residue.

真核生物翻译起始因子5A(eIF5A)是一个分子量约18 kDa的酸性蛋白,其序列从古细菌到哺乳动物高度保守,并广泛存在于各种真核生物细胞中。eIF5A是迄今为止唯一一种已知含有特殊氨基酸残基hypusine的蛋白质。hypusine是一种蛋白翻译后修饰产物,它的形成对eIF5A的功能完整至关重要,相关的研究结果表明hypsine在控制细胞周期循环的过程当中扮演着一个重要的角色。

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从有历史以来,英国,在此地早期居住的是凯尔特人,已经被征服了三次。

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