发作

Days after a convulsant dose of KA, the seizure susceptibility were found in KA+NS group and enhanced in KA+PL017 group, whereas significantly decreased in KA+β-FNA group (p.01).β-FNA prolonged the latency and reduced the stage of seizures in dose-dependent manner.

结果显示，一次给予惊厥剂量KA后7天，KA+NS组的癫癎发作敏感性形成；MORs激动剂组（KA+PL017）动物出现癫癎发作敏感性增强；与上述两组比较，MORs拮抗剂组动物癫癎发作敏感性明显降低（p.01），β-FNA以剂量依赖方式延长癫癎发作的潜伏期、降低发作级别。

Seizure frequency decreased by at least 50% in 47% of patients, by at least 75% in 24% of patients, and by 100% in 7% of patients. Of those receiving oxcarbazepine monotherapy, 59% had at least a 50% reduction in seizure frequency, 36% had at least a 75% reduction in seizure frequency, and 10% were seizure-free. Adverse events reported most frequently were dizziness in 46%, headache in 32%, fatigue in 30%, diplopia in 30%, nausea in 26%, abnormal vision in 21%, and somnolence in 21%.

结果在全部完成试验的患者中，47%的患者其发作频率下降至少50%，24%的患者发作频率下降至少75%，7%的患者2年间不再发作；而仅服用oxcarbazepine的患者中，59%的患者其发作频率下降至少50%，36%的患者其发作频率下降至少75%，10%的患者其发作频率100%下降；在副作用的部分，常见的有晕眩46%、头痛32%、疲倦30%、复视30、恶心26%、异常的视觉21%，以及嗜睡21%。

There were 613 breaks of ischemia symptomless in which 504 broke while at rest or sleeping, lasting for 3～5min and 88 breaks were symptomatic in which 53 broke while at rest and 25 broke in daily activities, lasting for 1～3 min and there were significant changes of ischemia on DCG and the ST segment descent for 0.1～0.3 mV.

结果：138例患者24h监测发现在所有ST段下移1mm以上的缺血发作701次，无症状发作613次，其中休息和睡眠时发作504次，持续时间为3～5min；有症状发作88次，其中休息和睡眠53次，日常活动时 25次，持续时间为 1～3 min，DCG检测中有明显的心肌缺血表现，ST段降低幅度0.1～0.3mV。

RESULTS Based on the epilepsy typing method and Video-EEG data,54pa-tients（42.2%）were diagnosed for epilepsy syndrome in the128child patients,including25cases of benign epilepsy of children with centrotemporal spikes,3cases of childhood ab-sence epilepsy,1case of juvenile myoclonic epilepsy,5cases of frontal lobe epilepsy,13cases of West syndrome and7cases of Lennox-Gastaut syndrome.The types of epilepsy seizures in49（38.3%）patients were conformed,including10cases of tonic and/or clonic seizures,33cases of partial seizures,5cases of myoclonic seizures and1cases of atonic seizures.

结果 128例癫痫患儿中有54例（42.2%）进一步确定了癫痫综合征的诊断，其中儿童良性癫痫伴中央-颞区棘波25例，儿童失神癫痫3例，少年肌阵挛癫痫1例，额叶癫痫5例，West综合征13例，Lennox-Gastaut综合征7例；有49例（38.3%）可明确其发作类型，其中强直或阵挛发作10例，部分性发作33例，肌阵挛发作5例，失张力发作1例，另外有25例（19.5%）尚无法分类。

Experts divide seizures into generalized seizures (absence, atonic, tonic-clonic, myoclonic), partial seizures, nonepileptic seizures and status epilepticus.

专家将癫痫发作分为全面性发作（意识丧失、肌肉失张力、强直－阵挛、肌阵挛），部分性发作（简单部分性发作和复杂部分性发作），非癫痫性发作和癫痫持续状态。

ResultsIdiopathic nocturnal frontal lobe epilepsy has distinctive clinical seizure characteristics. The onset age is younger than 20 and the ratio of male cases to female cases is 2 to 1. The most notable clinical characteristics are nocturnal clustered postural or dystonic seizures and complex motor activities, with 14% of the patients have epileptic family history. The interictal routine EEG of 22.9% and active EEG of 28% cases in wakeness and 38% cases in sleep showed frontal lobe epileptiform discharge while the ictal EEG of 66.7% cases showed frontal lobe epileptiform discharge. Drug therapy is effective in 80% cases with 30% completely controlled.

结果 特发性夜间额叶癫痫具有特征性的临床发作特点，大多数于20岁之前起病，男女比例2：1，以夜间成串的偏转性、姿势性强直及过度运动发作为最显著的临床特征。14％有阳性癫痫家族史。22.9％清醒发作间期常规脑电图及28％清醒发作间期动态脑电图可见额叶癫痫样放电，38％患者的睡眠发作间期动态脑电图可见额叶癫痫样放电，66.7％患者的发作期脑电图可见额叶癫痫样放电。80％药物治疗有效，30％可完全控制。

The extracellular amino acid neurotransmission levels in hippocampus of free-moving rats were detected by microdialysis with HPLC.3. Results:(1) The extracellular GAB A concentration in the CA1 area decreased immediately after the administration of PTZ but increased at about 3d after PTZ injection and lasted about 2 weeks. However, Glu level increased remarkably after the PTZ injection and decreased at 3d until 14d after PTZ injection.

结果： (1)在发作期，细胞外液GABA的浓度为38119.7±912.7nmol／L，较发作前明显下降，在发作后3天升高，发作后14天仍有升高；而Glu的浓度在发作期为4742.0±201.2nmol／L，较发作前升高，在发作后3天下降，瘫痛大鼠海马区细胞外液氨基酸的动态变化和托毗酷对癫痛大鼠辛l〕经元损伤的保护作用中文提要在发作后14天仍低于发作期。

Results The age of the onset of symptoms ranged from 3 to 12 years. The clinical attacks lasted a variable time from 1 hour to more than 3 weeks. Definite medical causes were identified in 78% of the patients. Each patient had a prolonged change of consciousness, accompanied by psychological and behavioral changes. The characteristics of ictal EEG in CPSE patients generally included slow activity and δ or θ activity in the temporal region. After antiepileptic drug treatment, the conditions of 11 patients were under complete control, 4 patients had no CPSE but complex partial seizures, and 2 patients had no improvement.

结果 17例CPSE患儿起病年龄为3～12岁，临床发作持续时间为1 h～3.5周；78%的患儿有明确的病因，CPSE临床表现多样，所有病例均有意识障碍，同时伴有不同程度的精神和行为异常，发作期脑电图主要以基本电活动变慢伴颞部局灶性慢波或痫样放电的持续或周期性发放为特征，经抗癫痫药物等治疗，11例患儿持续发作完全控制，4例持续状态控制，仅有部分性发作，2例未能控制。

Results The concordance between the location of MEG spike foci and the location identified by the ictal and interictal EEGs was 76.6% and 80.9% respectively, and the concordance with ECoG was 80.0%. In 39 operated patients, Engel Ⅰ was achieved in 21,Ⅱ in 10, and Ⅲ in 8. In the operated patients, intraoperative proper management was performed according to MEG-showed eloquent foci in 29 whose area to be excised involved the eloquent cortex, without postoperative exacerbation of neurosurgical dysfunction.

结果 MEG显示痫灶位置与发作间期和发作期V-EEG结果吻合率分别达76.6%和80.9%，与发作间期和发作期ECoG的吻合率均为80.0%。39例手术病人中，术后Engel Ⅰ级21例，Ⅱ级10例，Ⅲ级8例；其中29例拟切除的区域涉及到解剖学意义上的功能区，术中根据MEG显示的功能区位置进行了适当的处理，术后神经系统功能障碍未加重。

Results Twenty-one of 60 children (35.0%) whose episodes had been diagnosed as epileptic seizures were identified as non-epileptic attacks by ictal Video-EEG. Twenty-four of 28 cases (85.7%) with other seizures were identified as non-epileptic attacks.

结果 经发作期Video-EEG监测证实，60例初诊为癫痫性发作的患儿中，21例(35%)为非癫痫性发作；28例其他症状发作中，24例(86%)为非癫痫性发作。102例痫样放电患儿中82例(80.4%)确定了发作类型，35例(34.3%)确定了癫痫类型。

This is not an ordinary box, which is used as a background picture of the dialog box, very pretty.

详细说明：这可不是一个一般的对话框，它是用图片作为背景的对话框，非常好看。

Conceal me what I am,and be my aid for such disguise as haply shall become the form of my intent.

遮掩我的身份，帮助我，我的面具将成为我的目的。