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The results showed that chemical drugs could promote deletion of GAA triplet repeat associated with friedreich ataxia.

试验结果表明,化学药物可以促进与Friedreich共济失调相关的GAA重复序列发生删除。

The effects of FPL andits three ingredients on growth of ovary,on micro-and ultra-structure andAlkaline phosphatase activity of endometrium,on structure andkeratinization rate of exfoliated cells in vaginal epithelium in mice,onmicrocirculation in rat and on uterine kinesis in rabbit were respectivelyobserved by the techniques of light and electron microscopes,histochemistry,microcirculation and organ cinetography.The results have confirmed themechanism of FPL for the sterility caused by ovary standstill and persistentcorpus luteum to be as follows:(1) a weak estrogen-like role which canprompt development of ovary,proliferation and secretion of endometrium andvaginal epithelium and cornification of exfoliated cells in vaginal epithelium;(2)enhancing AKP's activity of endometrium;(3)improving microcirculation;(4) exciting uterus.

分别采用光学显微镜和电子显微镜技术、组织化学技术、微循环技术和器官运动描记等现代医学实验技术,观察了促孕液对小白鼠的卵巢发育、子宫内膜的显微和超微结构和碱性磷酸酶活性、阴道上皮结构和脱落细胞的角化率、对大白鼠的微循环和对家兔的子宫运动的影响,结果证实了促孕液治疗卵巢静止、持久黄体的机理:(1)微弱的雌激素样作用,能刺激卵泡发育,促进子宫内膜和阴道上皮增生、分泌和阴道上皮脱落细胞角化;(2)提高子宫内膜碱性磷酸酶的活性;(3)改善微循环;(4)促进子宫运动。

In order to comply with Article 303 of the NAFTA, Mexico created 20 sectoral promotion programs for the following industries: electrical; electonics; furniture; toys; footwear; metals and minerals; machinery and equipment; photography; agricultural machinery; chemicals; rubber and plastics; steel; pharmaceuticals and medical equipment; transportation equipment; paper and cardboard; wood; leather and leather products; automobiles and autoparts, and textiles and apparel.

为遵循NAFTA第303款协定,墨西哥已建立了覆盖以下行业的20个产业促进计划:电力、电子、家具、玩具、鞋类、金属和矿业、机械设备、照相业、农业机械、化学制品、橡胶塑料、港、药品及医疗设备、交通设备、造纸及纸板、木材、皮革及皮革产品、汽车及零配件、纺织及服装。

Thus,acute radiation sickness of moderate degree was ascertained.It was deduced that 3 other members in Feng's family died of ARS.Altogether about 100 ictims were found.Conclusion When ealuating a patient with suspicious burn without a history of contact of heat or fire and caustic chemicals and the patient has nausea,omiting,epilation and decrease in white blood cells,the possibility of radiation exposure exists.If some patients with aboe manifestations are found in a same family the radiation exposore may be more probable.

如遇到难以解析的皮肤烧伤病变,排除热或化学烧伤后,应考虑放射烧伤,对有恶心,呕吐,脱发,口腔溃疡,外周血细胞减少者,更支持诊断;如家中成员中相继发生上述同类症状者更应高度怀疑,并作相关检查确诊;简易隔简可为一般医院所采用;细胞因子可促进造血功能恢复,缩短病程。

Objective To explore livin, MTA1 and the caspase3 protein expression, their correlation and clinical pathology in colon cancer Methods The expressions of livin, MTA1 and caspase3 protein in 88 cases of colon cancer were detected by immunohistochemistry stainingResults Livin, caspase3 protein and MTA1 positive expression rates in colon cancer tissues were more than those in tissues beside the cancer Furthermore there were obvious relevance between livin protein, MTA1 positive expression rate and degree of histodifferentiation and lymph node metabasis and between caspase3 protein positive expression rate and degree of histodifferentiation of colon cancer Caspase3 protein expression had prominent inverse correlation with the livin expressionConclusions ①Over expression of livin having inhibtion on colon cancer is one of important factors of colon carcinogenesis ②Caspase3 protein expression in colon cancer tissues is inhibited to less and has prominent inverse correlation with livin expression Accordingly, suppressing caspase3 protein activity is one of channels, by which livin promotes colon carcinogenesis ③MTA1 plays the important role in histodifferentiation degree and lymph node metastasis of colon cancer

采用免疫组织化学染色方法检测88例结肠癌组织中Livin,Caspase3 及MTA1的表达情况。结果(1)结肠癌组织中Livin的阳性表达率显著高于癌旁组织,且Livin的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。(2)结肠癌组织中Caspase3蛋白的阳性表达率显著高于癌旁组织,且Caspase3蛋白的表达与结肠癌的组织分化程度显著相关。(3)结肠癌组织中MTA1的阳性表达率显著高于癌旁组织,且MTA1的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。(4)Caspase3蛋白的表达又与Livin的表达呈显著负相关。结论(1)Livin在结肠癌组织中过表达,它可能是促进结肠癌发生的重要因素之一。(2)Caspase3蛋白在结肠癌组织中表达被抑制而降低,且与Livin的表达呈负相关。因此,抑制Caspase3蛋白的活性是Livin促进结肠癌发生的途径之一。(3)MTA1对结肠癌的组织分化及淋巴转移发挥重要作用。

The universal research in microscopic tribological mechanism of contact, adhesion, friction, molecular-level solid-liquid interaction, tribochemistry, triboelectricity etc, in the interaction among goetmaterials or between goematerials and artificial materials during geomotion, were reviewed and analyzed.

2综述和分析了地质运动过程中普遍存在的微观摩擦机制如接触、粘着、分子级流体-固体相互作用、摩擦化学、摩擦电性等的研究概况,认为地质摩擦学的研究应具有宏观和微观两个层次,对地质运动的微观机制的研究将促进对地质材料的地球物理、化学和力学性质的研究,并有助于对各种尺度上的地质运动过程的理解

The students can improve their ability of learning chemistry while their ability of metacognition is improved. 2. The mode of training metacognition , which is founded in chemistry teaching of junior middle school for the learning disabilities students, and its specific training measures are efficient and actable to improve the chemistry study of the learning disabilities students.

我们所构建的在初中化学教学中对学习障碍学生进行元认知训练的模式及在此模式下的具体训练措施是有效的、可行的,对化学学习障碍学生的学业成绩的提高有促进作用。

Because of good selectivity to anions in solution of calix[4]pyrroles, the synthesis of calix[4]pyrrole-bonded stationary phase will also provide new means for separation to anions and neutral substances in chromatography and promote the development in supramolecular chemistry.

基于杯[4]吡咯化合物在溶液中对阴离子的选择性识别性能,利用其对色谱固定相进行改性以合成针对阴离子和中性小分子化合物的色谱柱将为色谱分离技术提供新的手段,推动超分子化学在分析化学中的应用并促进杯吡咯化学的发展。

MAIN OUTCOME MEASURES: Morphology change of spinal cord was detected by light microscope and electronmicroscope, secreted brain-derived neurotrophic factor was measured by immunohistochemistry and PT-PCR, and the combine behavioral score was used to assess the functional recovery of spinal cord. RESULTS: Immunohistochemistry result showed that OECs transplantation could partly reduce the number of apoptosis cells in spinal gray matter, delay cells reduction in spinal white matter, and accelerate the medullary sheath repair and regeneration.

主要观察指标:应用光学显微镜、电子显微镜观察脊髓形态的变化,采用免疫组织化学、PT-PCR 的方法检测脊髓组织脑源性神经营养因子的分泌,以改良的Gale联合行为评分法对脊髓功能进行评定,结果:免疫组织化学检测显示,嗅鞘细胞移植能部分改善大鼠脊髓灰质神经细胞的凋亡程度,延缓白质神经纤维的减少,促进髓鞘的修复与再生。

Each 1 μL site of spinal cord receiving 109 /L OECs at the speed of 1μL/ min. MAIN OUTCOME MEASURES: Morphology change of spinal cord was detected by light microscope and electronmicroscope, secreted brain-derived neurotrophic factor was measured by immunohistochemistry and PT-PCR, and the combine behavioral score was used to assess the functional recovery of spinal cord. RESULTS: Immunohistochemistry result showed that OECs transplantation could partly reduce the number of apoptosis cells in spinal gray matter, delay cells reduction in spinal white matter, and accelerate the medullary sheath repair and regeneration.

主要观察指标:应用光学显微镜、电子显微镜观察脊髓形态的变化,采用免疫组织化学、PT-PCR 的方法检测脊髓组织脑源性神经营养因子的分泌,以改良的Gale联合行为评分法对脊髓功能进行评定,结果:免疫组织化学检测显示,嗅鞘细胞移植能部分改善大鼠脊髓灰质神经细胞的凋亡程度,延缓白质神经纤维的减少,促进髓鞘的修复与再生。

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