乙酰化作用

Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression.

赖氨酸乙酰化是可逆的蛋白翻译后修饰，在基因表达调控中起重要作用。

Our data demonstrate that the regulatory scope of lysine acetylation is broad and comparable with that of other major posttranslational modifications.

我们的数据显示赖氨酸乙酰化是一种调节范围很宽的翻译后修饰作用。

On the other hand, we suggest that the STAT3-induced histone deacetylation in the IL-4 promoter may play an initial role in IL-4 suppression.

另一方面，我们认为STAT3诱导的IL-4启动子组蛋白去乙酰化在IL-4基因的抑制中发挥了起始性的作用。

HDAC1 has been shown to interact with many key hematopoiesis transcription fators and to influence their activities.

组蛋白去乙酰化酶在血细胞生成和白血病生成中发挥着重要的作用。

Objective Consequently, by constructing the pcDNA3-HA-hdacl, a HDAC1 eukaryotic expression vector, we were to study the interaction between HDAC1 and ERa and ERB in vitro and the effects of HDAC1 on the ERa and ERB at the protein level. So we can partly reveal the multiplication, differentiation and cancerization of lacteal gland cells.

目的 本文意在通过构建可在真核细胞中表达的重组质粒pcDNA3-HA-hdacl，研究组蛋白去乙酰化酶1(HDAC1)和雌激素受体ERα和ERβ在体外的相互结合作用，以及HDAC1对ERα和ERβ蛋白水平的影响规律，从而在一定角度揭示乳腺细胞的增殖、分化和癌变的过程，为更好地寻找治疗癌症的药物靶标打下基础。

We demonstrate that both the IL-5 mRNA expression and IL-5 protein production were stimulated by TSA and NaBu treatments. Chromatin immunoprecipitation assays showed that treatments of TSA and NaBu caused hyperacetylation of histones H3 and H4 at the IL-5 gene promoter in Jurkat cells, which consequently promoted the exogenous luciferase activity driven by this promoter.

TSA和丁酸钠能促进IL-5基因的mRNA和蛋白的表达水平，并增强该基因启动子所介导的外源荧光素酶报告基因的活性，这一增强作用与两种抑制剂介导的IL-5基因启动子上组蛋白H3和H4的高乙酰化有关。

The methodrapidly separates a large amount of different kinds of urushioldiacetates.Because the silver ion is very sensitive to theconfiguration and the degree of unsaturation of the unsaturated bonds,urushiol diacetate were well separated.

本文采用涂渍〓的离心旋转薄层层析法，发挥分离速度快，分离量大，固定相利用率高，分离效果好及〓对双键位置及构型作用灵敏等优点，因而使乙酰化漆酚达到了满意的分离。

Firstly, 3-ethylthiobutanal was prepared from crotonaldehyde reacting with ethanehiol in triethylamine with high yield. Secondly, methyl acetoacetate was converted to 6-ethylthiohept-3-en-2-one by three steps via hydrolysis, condensation with 3-ethyltio-butanal and dehydration, then 6-ethylthiohept-3-en-2-one was cycloco ndensed with dimethyl malonate by Michael addition and Claisen condensation, followed by saponification and decarboxylation to give the intermediate of 5-(2-ethylthiopropyl)-cyclohexane-1,3-dione.

首先，以巴豆醛与乙硫醇为原料，在三乙胺的催化作用下高收率制得3-乙硫基丁醛；然后从乙酰乙酸甲酯出发，通过碱水解、与3-乙硫基丁醛缩合、脱水三步反应合成6-乙硫基-3-烯-2-庚酮，接着6-乙硫基-3-烯-2-庚酮与丙二酸二甲酯通过Michael加成和Claisen缩合成环，再通过皂化和脱羧反应生成中间体5-[2-丙基]-1，3-环己二酮；再与丙酸酐反应丙酰化，最后与0-3-氯-2-丙烯基羟胺肟化，得到目标化合物烯草酮。

Objective: To investigate the arrest effect of diallyl disulfide in the cell cycle of human nasopharyngeal carcinoma CNE2 cell line and its molecular mechanism.

目的：在前期工作的检测上，进一步探讨二烯丙基二硫(diallyl disulfide， DADS)对人鼻咽癌CNE2细胞周期的阻滞作用，并研究组蛋白乙酰化状态及其调控p21WAF1蛋白表达改变的情况。

Objective To investigate whether trichostatin A possesses antitumor activity against human colon cancer ceils.

目的 研究组蛋白去乙酰化酶抑制剂曲古菌素A对结肠癌Lovo细胞增殖活性的抑制作用。

Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来，英国，在此地早期居住的是凯尔特人，已经被征服了三次。

Bluetooth OBEX File Transfer Enables the sending and receiving of files on your phone via Bluetooth.

蓝牙OBEX文件移动允许经过蓝牙传送和接受文件。。。。