查询词典 soman

The results showed that the four stereoisomers of soman were well separated under the defined chromatographic conditions. CP-）soman was only detected stereoisomer in the intoxicated rabbit blood and eliminated rapidly, the toxicokinetics could be described by a two-compartment model after rabbits received soman via vein.

结果可见梭曼4个异构体在确定的气相色谱条件下得到了较好地分离；给兔iv梭曼43.2 μg·kg-1后，血中仅测到一对CP梭曼，其消除过程符合二室开放模型， V d=2.1 L·kg-1， t 1/2α=4.5 s， t 1/2β=72 s， AUC(15～300 s)=2.08 mg·s·L-1， CL =21 mL·kg-1·s-1，血中CP梭曼在血中消除过程反映了机体对梭曼毒性异构体的解毒过程。

To know the abzyme mechanism of soman hydrolysis, the structure-activity relationship of soman and abzyme was studied.

为了解其催化水解梭曼的机制，需对其进行构效关系研究。

Methods Wistar rats were randomly divided in to four groups: normal control group,high altitude hypoxia group,soman intoxication group and hypoxia +soman intoxication group.

实验大鼠随机分为正常对照组、高原缺氧组、梭曼中毒组和缺氧复合梭曼中毒组。

Objective:To establish a method for determination of the concentration of the stereoisomers of soman in mice brain and diaphragm after soman was subcutaneously administrated to mice.

梭曼有一个不对称的碳原子和一个不对称的磷原子，因此有 4个光学异构体，即CP ，CP ，CP ，CP ，这些异构体的毒理学及代谢特性差别很大。

A sensitive and credible gas chromatographic method for analysis of soman stereoisomers was established to observe its elimination in blood of rabbit after intoxicated with soman via vein.

建立梭曼手性异构体气相色谱分析方法以研究兔静脉染毒后血中游离梭曼的消除过程。

RESULTS: Administration of the soman (60 μg·kg-1, sc) led to a rapid reduction in body temperature. Administration of scopolamine (1 mg·kg-1, ip) markedly blocked the hypothermic effect of soman but administration of methyl scopolamine (1 mg·kg-1,ip) had no effect on the hypothermia.

结果： 皮下注射梭曼(60 μg*kg-1)后可引起体温快速的降低，腹腔注射东莨菪碱(1 mg*kg-1)可明显阻断梭曼的降温作用，注射甲基东莨菪碱(1 mg*kg-1)对其降温作用无明显影响。

Results The changes of ［Ca2+］, the contents of CaM, cAMP were significantly higher in hypoxic and soman intoxicated group than in soman intoxicated group and control group under hypoxia; but the activity of Ca2+/CaM-PK Ⅱ were significantly decreased.

结果 缺氧中毒组PC12细胞cAMP、CaM含量在中毒后24 h明显高于单纯中毒组、缺氧对照组和正常对照组；缺氧中毒组PC12细胞Ca2+/CaM-PK Ⅱ活性在中毒后24 h明显低于单纯中毒组、缺氧对照组和正常对照组。

The levels of asparate in 6 brain regions including striatum cerebral cortex,hippocampus,midbrain,cerebellum,diencephalon and olfactory bulb at 5,30 and 90 min after seizure were significantly decreased as compared with the control.Conclusion:The excitatory amino acid transmitter activity may play an important role in soman-induced seizures.

梭曼中毒后脑内谷氨酸和天门冬氨酸水平显著降低，递质耗竭是递质活动增加的征象，因此，谷氨酸和天门冬氨酸递质活动增加可能在梭曼中毒性惊厥的发生和维持中起重要作用。

Objective: To explore the role of calcium in the injury of nerve cells induced by soman intoxication and its mechanism.

目的：探索钙在梭曼中毒神经细胞损伤中的作用及其机理。

Methods:Chiral capillary gas chromatographic analysis method with large volume injections was used to separate the stereoisomers of soman.

建立灵敏、特异的梭曼 4个光学异构体的分析方法对研究梭曼中毒后体内代谢过程、解毒药物的药理学评价及中毒诊断都具有重要意义。

Panorama Many people are dancing in a large sitting room.

在一个大客厅里，许多人在跳舞。

We fully understand how a microwave oven cooks food, it is first necessary to talk ...

我们充分理解一个微波炉煮的食物，这是首先要谈。。。