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Niemann-Pick disease type C is a fatal, neurovisceral storage disease neuropathologically characterized by cytoplasmic sequestration of cholesterol in neurons and progressively widespread neuronal loss, caused by mutations in genes NPC1 and NPC2 (also HE1) which encode for proteins required for the intracellular trafficking of cholesterol from lysosomes to late endosomes.

C型Nimann-Pick病是一种致命性的神经内脏脂质沉积病，其主要病理特征为广泛、进行性的神经元脱失，它由分别位于18号和14号染色体上编码与细胞内转运胆固醇有关蛋白质的NPC1和NPC2基因突变所致。

The progress that this means liaison man adequately already the plan mode from the tradition is progressively to commercialize, the mode of diversity transfers, form the nominatival bureau that traffic future develops with this.

这充分意味着交通的发展已从传统的计划模式逐步向市场化、多元化的模式过渡，并以此形成交通未来发展的主格局。

As the maturation of nucleus and cytoplasm, oolemma is also matured progressively.

同细胞核与细胞质成熟一样，细胞膜也存在成熟问题。

Methods Forty rats were randomized into normal control group and FS group. The normal control group was fed with conventional forage. FS group was fed with dry forage mixed with FS powder for 3 months, the preliminary dose of FS was 200 mgkg^(-1)d^(-1) and then increased progressively by l00 mgkg^(-1)d^(-1) to ensure over half of the rats having diarrhea, and the final dose was 2800 mgkg^(-1)d^(-1). The frequency and amplitude of colic slow wave were detected and the changes of myenteric plexus and ICC were observed by zinc iodide -osmic acid staining method.

方法］SD大鼠40只，随机分为2组：正常对照组、番泻叶组（饲以含番泻叶粉的乾饲料，起始剂量为200 mgkg^(-1)d^(-1)，以100 mgkg^(-1)d^(-1)剂量递增，保持对半数以上动物有泻下作用，连续3个月，终剂量为2800 mgkg^(-1)d^(-1)，检测大鼠结肠慢波的频率及振幅，采用碘化锌－锇酸法观察肌间神经丛及ICC变化。

The results showed that organic manure combined with constant chermical NPK fertilizer continually increased the content of soil organic carbon, readily oxidable organic carbon, humus cat.n, and their proportion in total organic carbon, HAC, FAC and HAC/FAC, but decreased Kos progressively.

结果表明，采用有机肥料配施常量NPK化肥，土壤有机碳、易氧化有机碳、腐殖酸碳及其占总有机碳比率、HAC、FAC和HAC／FAC不断提高，Kos持续下降，其变化速率表现为递减；长期不施肥和单施常量NPK化肥则造成Kos持续上升，其余指标以递减速率下降。

Results compared with the control group, the rats in the lactacystin group began gradually to have some behavioral symptoms, for example, the spontaneous motors decreased progressively, tardive dyskinesia, piloerection, tremor, contralateral rotations induced by apomorphine increased gradually.

结果 实验组给药后，随着时间推移大鼠开始出现渐进性自发性活动减少、动作缓慢、对外界刺激不自主竖毛、震颤；阿扑吗啡诱导的向健侧旋转运动逐渐增多。

Gu Saijun: Value to developing me, and hope the network sale of myself of stronger and stronger; is breathed out politicly, because of myself now is the enterprise changes carry to do, progressively move faces main service object hypostatic enterprise.

贾思军：对于发展我看好，且希望越来越强；我自己的网络营销策略的哈，因为我自己现在是企业化运做，主要服务对象逐步转移面向实体企业。

XRD characterization shows that with the increase of potassium content, polymolybdate species depolymerizes progressively, leading to the formation of K2MoO4 species.

XRD表征结果显示，随着元素K的加入，多钼物种逐渐被破坏，最终形成了单钼的K2MoO4物种。

We describe a 13 year old boy who complained of soft, postauricular, non-tender, progressively enlarging masses bilaterally that had been present for a number of years with associated bilateral neck lymphadenopathy.

此病例为13岁男性，主述双侧耳后肿块渐渐变大有数年的时间，摸起来柔软，并无疼痛及压痛感，合并有双侧颈部淋巴结肿大。

And then infected cells become progressively pycnotic and death from the monolayer gradually.

这与PRRSV能在MARC-145细胞上增殖，但不能在BHK-21、PK-15和IBRS-2上增殖是一致的。

Don not attempt to do something which you can not to do.

不要企图做那些办不到的事情。

The expression of CTGF and TNF-αweredetected by immunochemistry and the number of Clara Cells was calculated.

光镜下观察肺组织的病理变化，采用免疫组化染色观察肺组织中结缔组织生长因子和肿瘤坏死因子-α的表达和Clara细胞的数量。