查询词典 precontracted

ONOO〓 had direct vasoactive effect for relaxation of precontracted isolated pulmonary artery. Relaxing action of ONOO〓 was weak and was negtively regulated by endothelial cells, further supporting the notion that ONOO〓 may be involved in pulmonary hypertension in the early stage of ES.

用离体血管环检测张力方法，发现ONOO〓具有一定的舒张肺动脉作用，但舒张效应较弱，并受到血管内皮细胞的抑制性调节；抑制K〓通道和PARS活性可增强ONOO〓对离体兔肺动脉的舒张作用。

Our results indicated that (1) aortic rings with and without endothelium precontracted by NE to decreased pH induced a relaxation; aortic rings with and without endothelium to increased pH induced a contraction; there is no significant difference in presence and absence of endothelium .(2)NO levels had no significant change in isolated aortic rings presence and absence of endothelium to decreased pH and increased pH ;(3)sulfite levels in isolated aortic rings with endothelium reduced to decreased pH and increased pH. sulfite levels in aortic rings without endothelium had no remarkable change.

结果：①NE预收缩后，pH值降低对内皮完整和去除内皮胸主动脉血管环呈舒张作用；pH值升高对内皮完整和去除内皮胸主动脉血管环呈收缩作用；内皮完整组与去内皮组相比无显著性差异；②pH降低和升高对内皮完整和去除内皮血管环中NO含量无显著性影响；③pH降低和升高均可使内皮完整血管组织中亚硫酸盐含量减少，对去内皮血管中亚硫酸盐无显著性影响。

Results: Nitrendipine could relax concentration-dependently the arterial rings of the rat U-Ⅱ precontracted arteries -log

结果：尼群地平可浓度依赖性舒张大鼠U-Ⅱ预收缩的肺主动脉环［-log(EC50)=5.86±0.30， Emax=(73.73±15.40)%，以30nmol/L U-Ⅱ的收缩幅度为100%］。

Dilatiry of AS on rat thoracic aorta strips precontracted by noradremaline（1μmol/L）and KCl（30mmol/L）were proved.

结果 AS松弛去甲肾上腺素（1μmol/L）和氯化钾（30mmol/L）预收缩的大鼠胸主动脉条，其EC 50 分别（35.9±3.1）和（36.7±3.1）μmol/L。

Isolated rat pulmonary artery was perfused and the tension of the vessel was measured, the effect of isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate on the pulmonary artery precontracted by noradrenaline and concentration-response curves of 5-hydroxytryptamine(5-HT), endothelin-1(ET-1), U46619 and KCl was also observed.

制备大鼠肺动脉条，采用离体血管灌流方法，观察丹参素异丙酯对去甲肾上腺素预收缩动脉的舒张作用以及对多种血管收缩药量效曲线的影响。

Our results indicated that (1)SO_2 derivatives could dose-dependently relax the isolated aorta rings with or without endothelium precontracted by NE, no difference was found for the rings with and without endothelium;(2)Levels of cAMP and 6-Keto(PGI_2) in isolated aortic rings were increased by SO_2 derivatives in a dose-dependent way, which were independent of endothelium;(3)SO_2 derivatives decreased cGMP levels in the rings, but not significantly; The decrease of cGMP levels was also independent of endothelium;(4)No changes of TXB_2 in rings with or without endothelium were observed;(5)Whether presence or absence of endothelium, cAMP/cGMP and 6-Keto/TXB_2 ratios were increased significantly.

结果：①SO_2衍生物对去甲肾上腺素预收缩的内皮完整和去除内皮的大鼠胸主动脉血管环均呈浓度依赖性舒张作用，且其张力变化在内皮完整与去内皮的血管环之间无显著性差异；②SO_2衍生物可引起血管组织中cAMP、6-Keto(即PGI_2)含量剂量依赖性增加，其增加程度与内皮无关；③SO_2衍生物对血管环cGMP含量呈降低趋势但在统计学上无显著意义，且对去除内皮血管无显著影响；④SO_2衍生物对去内皮或内皮完整血管环的TXB_2含量均无明显影响；⑤无论是否去除内皮，SO_2衍生物均可引起cAMP／cGMP和6-Keto／TXB_2比值显著升高。

Whenadministrated to rings precontracted with 1μmol·L-1 PE in the absence ofextracellular Ca2+, a second extracelluar-calcium-dependent vasoconstrictioninduced by restoration of extracellular Ca2+ were also reduced by pretreatment of 50-200μmol·L-1 MLB dose-dependently.

在复钙实验中观察到，MLB 50-200μmol·L-1 不仅抑制PE 1μmol·L-1 诱导的内钙依赖性血管收缩，而且对复钙后外钙依赖性的血管收缩也有抑制作用。

Result: Isopropyl 3-(3,4-dihydroxyphenyl)-2- hydroxypropanoate exerted relaxation effect on the endothelium-intact artery precontracted by NE in a concentration-dependent manner, which was inhibited with denuded endothelium. The right-shift of the concentration-response curves of 5-HT, ET-1, U46619 and KCl.

结果：丹参素异丙酯可浓度依赖性舒张NE预收缩的完整内皮血管，去内皮后该作用明显降低；对5-羟色胺(5-HT)、内皮素(ET-1)，U46619和KCl量效曲线均表现浓度依赖性抑制。

Acclimatization 1.73±1.82** 0.61±0.06 0.98** P＜0.01 vs normoxic rats.After the aorta preparations were precontracted with NE at the concentration of 0.62 μmol/L, a ccumulative vasodilative effects of ACh were tested.

与常氧对照组相比，急性低氧和间断低氧习服后，大鼠主动脉对ACh各浓度(10- 9～10-5 mol/L)引起的舒张反应显著减弱(P＜0.01)，其最大舒张分别为常氧对照组的87.3％和79.7％，其EC50值分别为1.34和1.73 μmol/L，分别为常氧对照组EC50值0.20 μmol/L的6.7和8.6倍(表2)。

Results H-7 caused concentration-dependent relaxations of rat urotensin II precontracted arteries ［-log［EC50］=5.26±0.36, Emax =(97.21±17.86)% of the response to 10 nmol/L rat urotensin II］.

结果 H-7呈浓度依赖性舒张大鼠RUII预收缩的肺动脉干-log［EC50］=5.26±0.36， Emax =(97.21±17.86)%。

He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州，并在2005年伊瓦尔街，公寓生活。

Droperidol （ potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道，可能是 QT 间期延长的机制。