查询词典 oncogene

Twenty-seven differential proteins were tested by MALDI-TOF-MS, and 16 were identified. Of the 16 proteins, 13 were up-regulated in patients with HCC, including heat-shock protein 27, member RAS oncogene family (RAB14), actin, alpha 1 antitrypsin, RNA-binding protein regulatory subunit and so on. By contrast, the levels of proteins such as PDX6, HSPA8 and MnSOD were significantly reduced in HCC patients.

对27个差异蛋白质点进行了质谱分析，鉴定出16个蛋白质，在HBV相关性HCC患者PBMC中表达明显增强的有热休克蛋白质27、ras癌基因家族(RAB14)、肌动蛋白、α1-抗胰蛋白及RNA结合蛋白调节亚基等13个蛋白点；而PDX6、HSPA8及锰超氧化物歧化酶在HCC患者PBMC中低表达。

RESULTS: A well-resolved and reproducible 2-DE pattern of PBMC was obtained from patients with HBV associated HCC or LC. For HCC, the mean number of protein spots was 1186±43, with an average matching rate of 91.6%, and for LC, the mean number of protein spots was 1013±41, with an average matching rate of 90.2%. Twenty-seven differential proteins were tested by MALDI-TOFMS, and 16 were identified. Of the 16 proteins, 13 were up-regulated in patients with HCC, including heat-shock protein 27, member RAS oncogene family (RAB14), actin, alpha 1 antitrypsin, RNAbinding protein regulatory subunit and so on. By contrast, the levels of proteins such as PDX6, HSPA8 and MnSOD were significantly reduced in HCC patients.

结果：得到了分辨率较高、重复性较好的HBV相关性HCC及LC患者PBMC双向凝胶电泳图谱，HBV相关性HCC及LC患者PBMC凝胶的平均蛋白质点数分别为1186±43及1013±41；组内的平均匹配率分别为91.6%，90.20%对27个差异蛋白质点进行了质谱分析，鉴定出16个蛋白质，在HBV相关性HCC患者PBMC中表达明显增强的有热休克蛋白质27、ras癌基因家族(RAB14)、肌动蛋白、α1-抗胰蛋白及RNA结合蛋白调节亚基等13个蛋白点；而PDX6、HSPA8及锰超氧化物歧化酶在HCC患者PBMC中低表达。

Recent studies discovered that bcl-2 oncogene proteinexpressive male rate is high in cholangiocarcinoma cells,which maybe hasclose correlation with their cacoethic prognosis.

近年来研究发现胆管癌细胞中bcl-2癌基因蛋白表达阳性率较高，这可能与其不良的愈后密切相关。

Expression of epidermal growth factor receptor in breast can- cerin relation to steroid hormone receptors and prognosis. Epider- mal growth factor receptor is a transmemberane protein encoded by the oncogene c-erbB-1. It presents in all types of tumor cells and certain normal tissues, and it is thought to be related to cell carcinogenesis and uncontrolled cell growth.

表皮生长因子受体（Epidermal growth factor receptor，EGFR）是原癌基因c-erbB-1的表达产物，它是一种细胞膜受体，广泛存在于各种类型的肿瘤细胞和某些正常组织细胞中，与细胞癌变和失控性生长趋势有关。

CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体，是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成，即t（9；22），使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端，形成异常的bcr-abl嵌合基因，该基因转导出异常的mRNA，编码并翻译出P210蛋白，该蛋白具有很强的酪氨酸激酶活性，使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株，具有Ph染色体。

Chronic injury of Hepatic, immunologic response and the oxidized of DNA injury may cause gene mutation, carcinogenic gene;oncogene activated , tumor-suppressing gene devitalized, at last result in carcinogenesis.

本课题从基因及蛋白质两方面检测HDAC6在肝癌组织中的表达并探讨其与肝癌发生发展过程中相关的临床病理因素间的相关性，从而期望能够发现肝癌发病及发展和转移新的因素，为肝癌临床治疗提供理论依据。

Results The c-myc oncogene expression was foun...

结果 C -myc癌基因在口腔癌、白斑、扁平苔藓中表达的阳性率分别为 6 5 %、30 %和2 1%。

The mutation rates were 30% and 25% in LBC and FM,respectively. It was \ mation of infinite life span human cell strain by transfection with v-Ki-ras.Oncogene,1990;5:1415. 6\ Yang D,Louden C,Reinhold DS,et al.Malignant transformation...

这一结果表明p53基因突变在大肠癌中的普遍存在，并在大肠癌的发生过程中起着重要作用；而家族成员中发现p53基因突变将可为癌症的癌前监控和预防提供重要佐证。

PCR requires a specific DNA abnormality or marker, like an oncogene, in the leukemic or lymphomatous cells in order to identify residual abnormal cells.

为了识别残存的异常细胞，聚合酶链式反应需要一个特殊的DNA或RNA的畸形或标记物，在白血病细胞或淋巴瘤细胞中，如同致癌基因一样。

PCR requires a specific DNA abnormality or marker, like an oncogene, in the leukemic or lymphomatous cells in order to identify residual abnormal cells.

为了识别残存的异常细胞，聚合酶链反应需要在白血病细胞或淋巴瘤细胞中找到一个特定的DNA或RNA的异常点或标记物，如致癌基因。

Warden: That's a beautiful dog, but don't bring her again.

那是条漂亮的狗，但是不要再把她带来了。

You get up in the morning – no hangover!

你第二天早上起来的时候—不会宿醉！