查询词典 notch

This important step in the development of the body plan is known to involve the Notch signalling pathway, which regulates expression of the Nodal gene.

以前的研究认为Notch信号中的Nodal 基因和胞浆内自由钙是主要决定因素，最新的研究显示细胞外钙也是重要的因素，它能被Notch信号感受，并表达不同的基因。

Objective To investigate effect and significance of NOTCH-1 signaling pathway on proliferation and differentiation of human brain glioma stem cells.

目的 研究NOTCH-1 信号通路对人脑胶质瘤干细胞增殖和分化的作用及意义。

Notch receptors and ligands have been found to be expressed in dental epithelium or mesenchyme in the developing tooth, suggesting that Notch signaling may regulate odontogenesis.

Notch受体和配体在发育期牙源性上皮和间充质中的表达说明该信号可能参与调节牙齿器官发生。

NO of Notch are the first two letters in Nordic, CH are the first two letters in China, and the T can be interpretated as a + equalling to plus; altogether, the word speaks for itself.

NOTCH中的前两个字母NO也是是北欧这个单词的前两个字母，CH是中国的前两个字母，而T则可以被解释为&+&的意思。NOTCH这个词的组成表达了它的含义。

In the biological functionaddition, both biochanin A and hesperitin might inhibited the colony -formation forming ability of K562 cells through up-regulated Notch signaling. Besides,The treatment with biochanin A and hesperitin enhanced the erythroid-differentiation of K562 cells. It is important to investigate Tthe molecular mechanisms of biochanin A and hesperitin to regulate the endogenous CBF1-dependent Notch signaling will be further investigated.

在生物功能方面，biochanin A与hesperitin可能经由Notch讯息传导的活化，抑制了K562细胞群落的形成，除此之外，这两种药物均明显促进K562细胞往红血球分化。biochanin A与hesperitin对於CBF1所媒介之内生性Notch讯息传导的分子调控机制仍有许多问题尚未厘清，需要更多的实验与研究来讨论。

The moderate hypotrophic phenotype of lungs from animals bearing a Hes1 mutation, and the expression of Notch components in the distal lung bud during branching morphogenesis, together suggest that Notch may play a role in normal lung growth, especially in Clara cell precursors.

动物发生温和性肺营养缺陷表型时，Hes1发生突变，且在肺分支成形过程中，Notch在末梢肺芽中表达。这都说明：Notch对肺的正常生长起到一定作用，特别是在Clara细胞前体中。

We found that over-expression of the Notch ligand, Jagged-1, activated the Notch signaling pathway in DPSCs. Jagged-1 inhibited the odontoblastic differentiation of DPSCs in vitro.

Notch配体Jagged-1的过表达能激活DPSCs的Notch信号通路，在体外抑制成牙本质细胞谱系分化。

Notch1 is expressed by stem cells resided in the cervical loop epithelium, and Notch signaling pathway play a central role in fate decision of those stem cells. Notch receptors and their ligands are involved in both patterning and cell fate determination during odontogenesis. Moreover, many cell factors, which are closely related with odontogenesis, could regulate expression of Notch receptors or their ligands.

既往研究显示：早在牙齿发育期，Notch1就表达于颈环星网状层的干细胞中，是其保持干细胞性质的重要机制；Notch-Delta信号还与成釉细胞、成牙本质细胞分化有关，被认为是牙齿发育细胞分化多样性的原因之一；另外，目前已明确与牙胚细胞分化有关的生长因子如TGFβ、FGF、BMPs等均可诱导Notch受、配体的表达。

In this thesis, we find that dlg is indispensible in the establishment of anterior-posterior and dorsal-ventral polarity of drosophila oocyte. Removal of Dlg function from the posterior follicle cells using the FLP/FRT system leads to disruption of oocyte skeleton reconstruction that is elicited by the failure of those posterior cells to differentiate normally in mid-oogenesis. We demonstrate that abnormity of Notch, JAK-STAT and EGFR signal pathway in dlg mutants contributes to this aberrant differentiation. dlg null mutant also blocks the normal differentiation of two groups of anterior follicle cell-stretched cell and centripetal cell, but not border cell, with a lower penetrance. However unlike the result in posterior follicle cells, Notch and JAK-STAT signaling are both undisrupted in all mutant anterior follicle cells, implying other fate determinants may be involved.

我们的研究发现，后端滤泡细胞中的Dlg在果蝇卵子发生中期卵母细胞前后轴和背腹轴建立过程中也是必须的，PFC中dlg完全缺失型突变引起PFC的分化异常，导致卵子发生中期卵母细胞骨架重组异常，Stau、Grk等极性决定蛋白定位错误。dlg突变阻碍了Notch、JAK-STAT、EGFR等调节PFC分化的信号通路的激活。dlg突变的PFC也没有获得前端滤泡细胞命运。dlg突变不影响前端滤泡细胞群中边界细胞的分化，但是在一定程度上影响伸展细胞和向心细胞的分化，并且这种影响不依赖于前端滤泡细胞Notch或JAK-STAT信号激活的异常。

In mammals the Notch gene family comprise four related genes, Notch1-4, as the Notch ligands that encode transmembrane proteins. Ligand-receptor interaction mediated Notch activation ultimately leads to the conversion of effectors-CSL CBF1, Su(H, Lag-1 proteins, from repressors to transcriptional activators, and subsequent up-regulation of downstream targets.

在哺乳动物中，Notch基因家族包含了4个相关的基因，分别为Notch-1至-4，和Notch受质蛋白一样能被转译成膜蛋白；受质-受体间相互作用所引起Notch受体蛋白的活化会促使作用蛋白-CSL CBF1， Su(H， Lag-1 蛋白扮演抑制分子或者是转录活化分子上的角色改变，并且进一步地正向调节下游的标的基因。

But in the course of internationalization, they meet with misunderstanding and puzzlement.

许多企业已经意识到了这一点，但在国际化的进程中，仍存在一些误区与困惑。

Inorder toaccomplish this goal as quickly as possible, we'll beteamingup with anexperienced group of modelers, skinners, and animatorswhosenames willbe announced in the coming weeks.

为了尽快实现这个目标，我们在未来数周内将公布与一些有经验的模型、皮肤、动画制作小组合作。