查询词典 neutralizing agent

Containing many T cell epi-positions and neutralizing antibody epi-positions, the core protein region and envelope protein 2 of Hepatitis C virus structural protein may induce protective immunity responsion in body.

丙型肝炎病毒(hepatitis C virus，HCV)结构蛋白的核心蛋白和包膜蛋白2(E2)含有多个T细胞表位和中和抗体表位，可诱导机体产生保护性免疫应答。

Neutralizing potency of the patent recombinant anti-rabies virus McAbs, SO57 and SOJB,have been investigated broadly to different rabies virus strains in various animal models.100% Chinese Hamsters could be protected by 100IU/kg SO57 against China prevalent street rabies virus named SBD.We firstly established the mouse model to simulate human postexposure prophylaxis by rabies virus and found SO57 had the same function with HRIG against CVS or three China typical street rabies viruses.However,HRIG could not 100% protect the mice challenged with SBD street virus,rabies virus vaccine alone could not save life from rabies virus infection.The cocktail containing SOJB and SO57(1:1) did not do better than SO57 alone.

用不同的动物模型研究了具有专利的重组人抗狂犬病病毒单克隆抗体SO57、SOJB对不同狂犬病病毒株的中和作用，100IU/kg的SO57能100%保护被中国街毒株SBD攻击的中国仓鼠；首次用小鼠模型模拟人体被狂犬病病毒攻击后的治疗情况，在小鼠被CVS及中国街毒代表株攻击后，SO57与HRIG具有相近的对小鼠的暴露后保护作用；同时结果显示HRIG对SBD株攻击的保护率不能到达100%，仅使用疫苗是不能对感染病毒的小鼠百分之百的保护；SOJB与SO57 1：1联合使用未显示比SO57单独使用更好的保护效果。

Aslo the paper has dealed with the mechanism of the hollow cathode vacuum arc discharge and analyzed the starting arc process according to the neutralizing theory of ionized gas.

根据电离气体中性化条件，初步探讨了在低气压下空心阴极电弧放电的引弧过程，分析了影响低气压下空心阴极电弧放电引弧电压的因

According to the spetial conformational analysis and physical/chemical property analysis and by the aid of computer it can make molecular design of mimic polypeptide and designs the polypeptide molecule with activity for neutralizing LPS, and adopts the solid phase polypeptide chemical synthesis method to synthesize antibacterial/antiendotoxin mimic peptide with total or partial BPI bio-function.

本发明公开了通过计算机模拟设计、人工合成的66个抗菌／抗内毒素模拟肽，根据对BPIN端三个LOOP区的空间构象分析及物理化学性质分析，在计算机辅助下进行模拟多肽的分子设计，设计出具有中和LPS活性的多肽分子，用固相多肽化学合成方法合成抗菌／抗内毒素模拟肽，本发明的抗菌／抗内毒素模拟肽具有全部或部分BPI的生物功能，可以用于治疗G－细菌感染、人内毒素血症，具有分子量小、可以稳定重复生产的特点。

The nice biological activities of ScFv have established an important basement for further study of other antiricin neutralizing monoclonal antibodybased antidotes.

研究结果为研制基于中和性单抗的其他ricin拮抗剂奠定了重要的理论和实践基础。

The biological activities of ScFv obtained from 293T cell culture fluids infected by liposome were evaluated. RESULTS: The accession number of VH and VL genes of antiricin neutralizing monoclonal antibody was DQ389248 and DQ389245. ScFv could bind with ricin specifically. Inhibition percentage of culture liquid of 293T cell without dilution and with 2 times dilution was 33.7% and 29%, respectively. ScFv could neutralize the cytotoxic effects of ricin to SP2/0 cells at the concentration of 0.01-0.005 ng/mL in a nice doseeffect relation.

结果： 中和性单抗杂交瘤细胞4C13轻、重链可变区基因在GenBank中的登录号为DQ389248和DQ389245，ScFv与ricin可特异性结合，培养上清原液和2倍稀释液的抑制率分别为33.7%和29%；ScFv在ricin浓度为0.01~0.005 ng/mL时可中和ricin 对SP2/0细胞的细胞毒，随着ricin浓度逐渐增大，细胞存活率逐渐减低。

METHODS: The total RNA was obtained by TRIzol from an antiricin neutralizing monoclonal antibody hybridoma cell named 4C13 and heavychain and lightchain variable fragments were amplified by overlap PCR and accepted by Genbank of NCBI. VH and VL were linked by3 with a direction of VHlinkerVL and cloned to pCDNA3.1 vector expression system.

用TRIzol提取抗ricin中和性单抗杂交瘤细胞4C13总RNA，扩增其轻、重链可变区基因，登陆GenBank；用Linker3将VH和VL连接，用重叠延伸PCR克隆入真核表达载体pCDNA 3.1，用脂质体转染293T细胞，对瞬时表达产物进行生物学活性检测。

A series of antimony mercaptide compounds which formula are Sb 〓 and Sb S (CH〓〓COOR 〓(R represents an alkyl or aryl, aralkyl, n=0～2) have been synthesized. A new synthetic method has been invented to solve the defect of abroad patent method which has complex technological conditions and singleness intermediate compounds. A new catalyst QL-1 and preactivated antimony trioxide and other means have been used to avoid neutralizing, washing, separating and other procedures of intermediate and simplifing process flow at the same time. According to this new technique, a series of antimony mercaptides and their intermediate products have been synthesized with high yield.

合成了结构为SbS(CH〓〓COOR〓及Sb〓（R为烃基或芳烷基，n=0～2）的一系列硫醇锑化合物，针对国外专利报道的合成工艺存在着工艺条件苛刻，同时需多步完成，操作复杂，而且中间体品种单一的缺陷，发明了一种一步法合成硫醇锑化合物的新工艺，采用QL-1催化剂，且将三氧化二锑预先活化，变固—液相反应为液—液相反应，同时可免除中间体的中和、洗涤、分离等工序，工艺流程简化，产品收率高，且能制得系列硫醇锑产品。

The Arcane Formulas or Mental Alchemy (98 pages) Contents: Egohood; Establishing the Ego; Will-Focalization; The Excluded Middle; Mastering the Opposites; Neutralizing Rhythm; Cyclicity and Balance; Mentalism in a Nutshell.

晦涩的公式或心理炼金术(98页)内容：egohood；建立自我；会-聚焦；排除中间；掌握对立统一；产地节奏；周期性和平衡；唯心主义一言以蔽。

The Arcane Formulas or Mental Alchemy (98 pages) Contents: Egohood; Establishing the Ego; Will-Focalization; The Excluded Middle; Mastering the Opposites; Neutralizing Rhythm; Cyclicity and Balance; Mentalism in a Nutshell.

神秘的公式或精神炼金术(98页)目录：egohood；建立自我；会-聚焦；中间排斥；掌握对立统一；压制节奏；周期性和平衡；唯心主义一言。

Must have Coordination and negotiation skill, flexible ideas, and be punctilious person.

必须具备较好的协调与谈判能力，头脑灵活，工作认真仔细

Result: 18 patients are all with simple eye.The pigment mole lies in nasal and temple sides of the ball conjunctiva,in which 2 lie in lacrimal caruncle and semilunar plica.

结果：18例患者均为单眼，色素痣大多数位于内外侧睑裂部球结膜面，2例位于泪阜及半月皱襞，经激光治疗后，10例色素痣消失，有5例行再次激光后消失，2例行第三次激光后消失，1例第四次激光后消失。