查询词典 mutation stop

Mutation rate at exon of GH in five bovine species was very low with the percentage of 3.48%. The majority of nucleotide substitution was nonsense mutation and only one missense mutation was observed. Molecule tree based on haplotypes of bGH at exon 5 showed that differentiation was apparent relatively between Bubalus bubalis and Bos taurus, Bos indicus, Bos grunniens, Bos frontalis. There was no apparent differentiation among other four bovine species and they shared mutual ancestral sequence.

序列分析表明，5个牛种GH基因外显子5的遗传变异水平较低，平均核苷酸变异率约为3.48%，而且绝大多数位点的核苷酸替换是同义突变，仅发现1个错义突变位点；从GH基因外显子5序列单倍型构建的分子进化树来看，水牛与普通牛、瘤牛、牦牛及大额牛的分化相对比较明显，其他4个牛种之间并无明显分化，还享有共同的祖先序列。

Results Among 54 WD patients, 36 were found to carry Arg778leu mutation, among whom 15 were homozygote, 21 were heterozygote, the frequency of this mutation was 47.2%. Of 46 patients with hepatic damage, 36 were found to have the mutation of Arg778Leu, among whom 34 were found to have Leu770Leu polymorphism simultaneously.

结果 54例Wilson病患者中36例存在Arg778Leu基因突变，15例为纯合型，21例为杂合型，Arg778Leu等位基因突变频率为47.2 ％；46例伴肝损害的患者中33例存在ATP7B基因外显子8的Arg778Leu突变；36例Arg778Leu突变者中34例同时伴有Leu770Leu多态性。

1,After transfected the mutated mtDNA of colorectal carcinoma,the mtDNA D-loop region of the transfected cells displays new mutation points.2,The external source pieces of the mutated mtDNA can integrate to nuclear genome after transfection.3,There's no differences in apoptosis between combinations after transfected the mutation of mtDNA in NIH3T3 and LST cells.4,The mutated mtDNA may affect the action mechanism of occurrence and development in colorectal carcinoma through affecting its mtDNA mutation or integrating exogenetic mtDNA to its nuclear which may cause the abnormal expression of oncogene or anti-oncogene.

（1）转染突变的大肠癌细胞mtDNA后转染细胞的mtDNA均可发生多处的突变位点。（2）通过转染后突变的外源性的mtDNA可以整合到核基因组内。（3）突变的mtDNA转染LST细胞及NIH3T3细胞后，不影响转染细胞的凋亡改变。（4）mtDNA的突变可能通过影响体细胞mtDNA的突变和通过外源性mtDNA在核内的整合从而影响癌基因或抑癌基因的表达异常，从而参与肿瘤的发生发展。

1,After transfected the mutated mtDNA of colorectal carcinoma,the mtDNA D-loop region of the transfected cells displays new mutation points.2,The external source pieces of the mutated mtDNA can integrate to nuclear genome after transfection.3,There's no differences in apoptosis between combinations after transfected the mutation of mtDNA in NIH3T3 and LST cells.4,The mutated mtDNA may affect the action mechanism of occurrence and development in colorectal carcinoma through affecting its mtDNA mutation or integrating exogenetic mtDNA to its nuclear which may cause the abnormal expression of oncogene or anti-oncogene.

（1）转染突变的大肠癌细胞mtDNA后转染细胞的mtDNA均可发生多处的突变位点。（2）通过转染后突变的外源性的mtDNA可以整合到核基因组内。（3）突变的mtDNA转染LST细胞及NIH3T3细胞后，不影响转染细胞的凋亡改变。（4）mtDNA的突变可能通过影响体细胞mtDNA的突变和通过外源性mtDNA在核内的整合从而影响癌基因或抑癌基因的表达异常，从而参与肿瘤的发生发展。线粒体DNA；D―环区；突变；质粒；pcDNA3.1；转染

So far as reality means experienceable reality, both it and the truths men gain about it are everlastingly in process of mutation mutation towards a definite goal, it may be--but still mutation.

只要实在的意思是可以被人们所感知的实在，实在和人们所得关于实在的真理便永远处于变化过程之中——或许是朝着特定目标的变化，但说到底仍是变化。

Results EROD activities in liver of wild crucian from Zhangtan, Jiangjunyan, Fuyang and Wenyan (23.51±4.17, 16.79±7.39, 18.74±5.16, 18.65±8.86 nmol/) were significantly higher than that of Jiekou (7.84±2.42 nmol/g promin), and no difference was observed between the other sites and Jiekou. Three dose groups (0.25, 0.50, 1.00L/dish water sample extracts) were used in Ames test. Reversional mutation rate of TA98 colony exposed to extracts from Zhangtan was 2.21, 3.39, 6.95 without S9, and 2.70, 4.07, 6.23 with S9, respectively. The revesional mutation of TA100 colony was 2.55, 2.81, 5.36 without S9, and 1.73, 2.86, 4.14 with S9, respectively. Reversional mutation rate of TA98 colony exposed to 1.00L/dish extracts from Jiangjunyan with S9 was 2.22, and there was a dose-response relationship in reversional colony count. Ames tests of the other extracts were negative.

结果 樟潭、将军岩、富阳、闻堰点位野生鲫鱼肝EROD酶活性分别为(23.51±4.17)，(16.79±7.39)，(18.74±5.16)，(18.65±8.86)nmol/，明显高于街口[(7.84±2.42)nmol/]，其他点位与对照比较差异无统计学意义；樟潭水样浓集物在浓度为0.25，0.50，1.00 L/皿时在不加与加S9条件下，TA98回变菌落突变率MR值分别为2.21，3.39，6.95，2.70，4.07，6.23；TA100回变菌落MR值分别为2.55，2.81，5.36，1.73，2.86，4.14；Ames试验结果为明显阳性；将军岩水样浓集物在浓度为1.00 L/皿且加S9条件下TA98MR值为2.22，且在浓度为0.25，0.50，1.00 L/皿加S9条件下TA98回变菌落数呈剂量－反应关系，MR值分别为0.88，1.98，2.22；Ames试验结果为弱阳性；其他点位均为阴性。

All the LOH on 〓 and 〓 was observed in invasive ductal carcino- ma, carcinoma simplex, medulary carcinoma and scirrhous carcino- ma, no deletions at these sites were observed in any invasive lobular carcinoma and others. These results imply an etiological difference.P53 gene is a hot point gene in the occurrence and development of breast, cancer. PCR-SSCP analysis was performed to detect P53 gene point mutation in the region between exon 5 and 8, 5 of 12 (41. 6%) stage I breast cancer patients contain mutation of P53, 3 of 5 patients were accompanied by 〓 deletion. These results suggested that point mutation and allelic loss of P53 gene are two vi- tal genetic events in earlier stage of breast tumorigenesis.

我们还发现，〓和〓位点LOH均分布在乳腺浸润性导管癌、单纯癌、髓样癌及硬癌中，在浸润性小叶癌和某些特殊类型乳腺癌中全部为LOH阴性，上述位点LOH可能与某些组织学类型乳腺癌的发生有关。P53基因是乳腺癌形成过程中的一个热点基因，本研究对12例Ⅰ期乳腺癌组织标本中P53基因热点区域第5、6、7、8外显子点突变进行了测定，发现41.6％（5／12）的病人有P53基因一个或多个点突变，其中3例同时伴有〓位点LOH，表明P53基因点突变和等位基因缺失是发生在乳腺癌形成早期的一个重要遗传学事件。

Lusters of mutations in CP region, a A-to-C mutation at necleotide 1726, a A-to-T mutation at nt 1727 and a C-to-G mutation at nt 1730, were observed in eight of eleven AsCs developing acute exacerbation, Moreover, the clustering mutations were found negative in the state of AsC and positive after acute exacerbation in a subject.

P聚集变异与AsC首次肝炎急性发作有关。 11例中，8例出现CP聚集变异。且 1例在AsC状态时无CP变异，肝炎发作时出现CP聚集变异。(3)CP聚集变异合并CP双变异的乙肝患者，表现为重型肝炎或迅速进展为肝硬化；HBVDNA高水平；HBeAg/抗HBe转换。

The results showed:①Anthocyanin content in mature fruits was 132170 U·g-1FW in bud mutation which was very significantly higher than that in'Ralls'(49140 U·g-1FW);②Activities of PAL and UFGT were almost the same between the two materials, but CH I and DFR activitieswere significantly high in bud mutation, which were related to the increase of anthocyanin levels in the mutant;③Bagging treatment inhibited anthocyanin synthesis of bud mutation. But anthocyanin content had significantly increased after removing the bags. Activities of CHI and UFGT increased rap idly and were much higher than those in the control after the bag removal. The increase was consistentwith the imp rovement of anthocyanin levels.

结果显示：①在果实发育期间，芽变果皮的花青苷含量明显高于'国光'，尤其是成熟期芽变果皮花青苷含量为132170 U·g-1FW，而'国光'仅为49140 U·g-1FW；②在果实发育期间，两个品种间PAL 和UFGT的酶活性无明显差异，但芽变的CHI和DFR酶活性明显高于'国光'，表明芽变花青苷合成能力的提高与CHI和DFR酶活性高有关；③套袋抑制芽变果皮花青苷的合成，但解袋后花青苷的含量极显著升高，解袋后4种酶的变化趋势差异较大， CHI和UFGT活性均迅速升高，明显高于对照，这与解袋后花青苷迅速合成相吻合。

Compared with the exchange and mutation operation in genetic algorithm ,crossover operation becomes helpless when adaptive value of most individules in demes have little difference.The algorithm falls into local solution and can't be solved by exchange. Although mutation can make it shake off local convergence and jump out of local solution, denteric mutation may destroy the produced module that is constructive to form the optimal solution.

相比遗传算法中的交换和变异操作，当种群的多数个体适应值相差不大时交叉操作就显得无能为力，算法陷入局部解而不能由交换解决，突然变异能够使之摆脱局部收敛而跃出局部解，但是后期的变异可能破坏已产生的对形成最优解有建设性作用的模块。

The teacher likes the honeymouthed little girl very much.

老师很喜欢这个嘴甜的小姑娘。

Mr. Notker Bien's interests are traveling, spending quality time with the family and long-distance-running.

诺特卡·柏恩先生热爱旅游，长跑，以及和家人一起共度美好时光。