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Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

Its pathologic characteristics of indiscoverable growth and poor differentiation leads to the clinical figures, such as the difficult diagnosis in early stage, lower rate of redical resection, and insensitive to chemotherapy or radiotherapy, and in the end, the treatment efficacy of PGC has not been markedly improved for many years.

原发性胆囊癌占我国胆道肿瘤发病的第一位，其发病隐匿，早期诊断困难，恶性程度高，根治性手术切除率低，对化疗和放疗均不敏感，多年来疗效未能明显改善。

It is concluded that biomolecular structure and chemical components are markedly changed in the infarcted cerebral cortex.

结果显示：脑梗塞后大鼠大脑皮质的生物大分子的结构及化学成分均出现明显的变化，与脑梗塞的病理变化结果密切相关。

Anther gland amber; dark glands sometimes present on leaves but not forming inframarginal row; seeds with testa ± markedly papillose

花药腺体琥珀；在叶但不是形成inframarginal 排上的有时的深色的腺体宿存；显著的种子具种皮多少具小乳突 44

On MR images, fluid-fluid levels were seen in 12 cases (92%); the internal septations and walls of the cysts were inhomogeneously enhanced markedly, these septations and walls were not evident on T1WI, but with medium to high signal on T2WI.

CT显示21例（91%）病变由大小和数量不等的囊腔构成，其中19例（90%）CT扫描出现液-液平面；4例（17%）病变内出现局部实性区域，其中1例为完全实性病变；3例病变侵犯了邻近关节和骨。

GroupⅡ Six months after internal fixation, the cortex under the plate was so markedly disorganized that the whole layer of it was cancellized. At this time, the intracortical bone porosity was going up to 26 per cent.

本研究还表明，坚硬接骨板取出后骨量恢复和骨结构恢复并不是同步完成的，骨结构恢复往往迟于骨量恢复，而骨结构恢复延迟又可导致骨强度恢复延迟。

Intratracheal TNF-α Ab has markedly protective effect on lung injury after CPB.

气管内应用抗 TNF-α抗体能减轻 CPB导致的肺损伤。

Respiratory rate and isocitric dehydrogenaseactivity in plant rootsgrown at low-P supply were markedly lower than those at P-sufficient supply.

在缺磷条件下小麦根系的呼吸强度和异柠檬酸脱氢酶活性明显低于正常供磷处理，而PEPC活性与此相反。

Although this is meant,should browse by tens of thousands mailbox address, but this kind of painstaking work is necessary really, because,this is: You can be clear about 1 your user people can choose what mailbox, will adopt a few measure to avoid to be regarded as with this rubbish mail is deleted directly, what perhaps differ according to each mailbox is characteristic, will be behaved more markedly. 2 if what a few people use is company mailbox, then you can understand the trade that they pursue roughly, will provide the service that has specific aim more with this. 3 can correct a few apparent spelling mistake. If 4 has a competitor jumbly inside, can will delete.

尽管这意味着要浏览成千上万的邮箱地址，但是这种费力的工作确实是必要的，这是因为：1你会清楚你的用户们会选择哪些邮箱，以此来采取一些措施避免被当作垃圾邮件直接删除，或者是根据各个邮箱不同的特性，来表现得更为醒目。2如果一些人使用的是公司邮箱，那你就能大致了解他们所从事的行业，以此来提供更有针对性的服务。3能够修正一些明显的拼写错误。4如果有竞争对手混杂在里面，可以将之删除。

Results showed that DCF with different dosages could increase the frequency of micronucleated erythrocytes markedly,except the first injection of the dosage with 5 and 10 mg/kg,every group caused an increase in the frequency of nuclear abnormality erythrocytes,the effects in cell membrane and cytoplasm were less than the effects in karyon by DCF,and the most toxicity was exhibited after the second injection.

结果表明，注射DCF后所有剂量组均能引起中华蟾蜍红细胞微核细胞率显著升高；除5，10mg／kg剂量组在第1次注射后较对照组低外，其他注射剂量和次数均引起核异常细胞率升高，DCF对细胞膜与细胞质的影响小于其对细胞核的影响，在4次注射中以第2次注射后对红细胞的毒性效应最大。

The system can be widely used in belt weighing and batching process control,etc.

介绍了基于智能模糊控制的嵌入式配料系统的设计方法，对模糊PID控制过程和系统调零作了重点的讨论，同时给出了PID控制的程序流程图和系统定长调零子程序。

"I dunno," she answered,"but if you show me aroun', I'll recognize it from the lighthouse just outside the porthole."

"我不知道，"她回答说，"如果你能带我转转，我能认出来的，因为灯塔就在舷窗外。"