查询词典 knockout drops

Hubba is a powerful prediction tool for hub/essential proteins with a user-friendly interface.Hubba can decipher the critical keys inside biochemical pathways and complex network, there will be significant clues to provide candidates for gene knockout and potential drug-targets for developing novel treatment in cancer cells and emerging pathogens.

Hubba线上分析平台，可用以分析生物复杂网路交互作用系统中的重要枢纽分子，以图像化手法呈现重要性来对枢纽蛋白质排名，并显示这些重要结点之间的关连性，协助辨识疾病细胞内与感染过程中的重要网路次模组，及特定基因群所关连的小网路，提供网路医学研究与新的治疗方法的开发。

There is an excessive hypertrophy effect in cardiomyocytes from isolated neonatal eNOS gene knockout mice under the stimulation of hypermyotrophy inducing factor.

内皮型一氧化氮合酶基因敲除小鼠其离体心肌细胞在心肌肥大诱导因子刺激下产生过度增殖反应。

According to the successful experiences on transgenic animal production and animal cloning, gene targeting could be utilized in many fields including theory and application research on genomic modification (such as site-specific gene repair, genetic defect therapy, gene knockout, infaust gene modification, even the site-specific integration), improving expression level of specific gene in animal mammary gland bioreactors, and promoting the industrialization of transgenic animal production.

结合现有转基因动物和动物克隆技术方面的经验，利用基因打靶技术，开展动物基因组修饰的理论和应用研究，即可定点进行基因修复、治疗遗传缺陷、基因敲除失活不利基因，还可最终解决动物乳腺反应器存在的随机整合率高而表达率较低的问题，实现定点整合及乳腺特异表达，为转基因动物的产业化生产创造条件，代表了当今动物遗传学发展的主流方向。

Pylori, we mutated minD gene by insertional mutagenesis and knockout minE gene of H.

此两种突变株的形态都转变成细丝状的菌体。

To study the role of FoxO1 on myoblast proliferation and differentiation and the transformation of muscle fiber type in porcine,here we use yorkshire as experimental materials and detect the expression of genes related myogenesis and muscle fiber type in pporcine myoblast that was knockout or activated FoxO1,adopting the technology of RNAi,real time-PCR and Western blotting et al..

为探讨FoxO1对猪成肌细胞增殖分化及肌纤维类型转化的作用及机理，本试验以大白猪为研究材料，利用RNAi、real-time PCR、免疫细胞化学和Western blotting等技术，通过在原代培养的猪成肌细胞中敲除和激活内源活性FoxO1，检测肌肉形成与肌纤维类型相关基因的表达。

Although heart wall thickness was reduced overall, specific areas exhibited morphological changes consistent with myxomatous degeneration in the walls of knockout hearts.

尽管整体心室壁厚度下降，但是特定区域的形态学改变和基因敲除小鼠的心室壁粘液瘤的形成一致。

So far transgenic knockout models of AQP1, AQP3, AQP4 and AQP5, and a knock-in model introducing a point mutation (T126M) that causes autosomal recessive nephrogenic diabetes insipidus in human have been successfully established. Significant progresses have been made in characterizing the physiological functions of these AQPs by systematic mouse phenotype studies.

目前AQP1、3、4、5基因敲除和AQP2基因点突变的基因敲入小鼠模型（模拟人类常染色体隐性遗传尿崩症）已成功建立并广泛用于表型研究，在AQP水通道蛋白生理功能方面获得许多重要进展。

But that achievement pales in comparison to the team's progress to the knockout stages.

不过，球队更令人激动的无疑是闯进世界杯淘汰赛。

PartⅠGenistein thwarts the development ofatherosclerosis in LDLR-knockout mice BACKGROUND: Artherosclerosis and its complication are one of the maincauses for pathopoiesis and death.

第一部分Genistein对LDLR-／-小鼠动脉粥样硬化发生发展的影响研究背景动脉粥样硬化(artherosclerosis，AS)及其并发症是人群致病和死亡的重要原因之一。

It is estimated that there are about 40,000 functional genes.In order to understand those genes related to human diseases and the novel functional genes, the genetic manipulated mice including transgenic mice and knockout mice have been generated to facilitate the purpose.This transgenic core has been collaborated with industrial and research institutes for years, and has built up competitive know-how for transgenic mice, embryo cryopreservation, and pathogen free rederivation.

小鼠长期以来即为研究人类疾病最佳动物模式，2001年美国赛洛因公司已将小鼠129的两个品系之基因序列解码完成提供付费使用，2003年小鼠B6的基因序列也被Mouse Genomic DNA Sequencing Consortium解码完成，预估约有4万个功能基因，随著基因操控技术的成熟，制造出各种带不同基因缺陷的模式动物供生物医学研究已非难事。

World War II: Battle of Saipan - Americans take Saipan.

1944年的今天，美国在塞班战役中拿下塞班岛。

When the scorner, the rejecter of truth, has become presumptuous; when the routine of work in the various money-making lines is carried on without regard to principle; when the student is eagerly seeking knowledge of everything but his Bible, Christ comes as a thief.{DA 635.3

当讥诮和拒绝真理的人，到了任意妄为时，当追求财利者罔顾按道义经营谋利时，当学人正在兢兢业业地研究各种知识，而单把圣经丢在一边时，基督要像贼一样来临。