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Results ①Guttate lesion was predominant in active stage; guttate, nummularis and geogrphic lesion prevailed in steady stage; however, guttate, nummularis, cyclic and zonular lesion were mainly in restoration stage;②The most involved site was the scalp; the calf, elbow and thigh followed; and mucosa, nail and genitals were the least involved.

结果 ①524例寻常型银屑病患者进行期皮损以点滴状居多，稳定期患者以点滴状、钱币状、地图状为主，环状、带状则少见。而退行期则以点滴状、钱币状、环状、带状多见。②103例寻常型银屑病患者皮损的初发部位和421例再发患者皮损的现分布部位均以头皮最多，其次是小腿、肘、大腿等，最少见于粘膜、甲、外生殖器等。

Chk1 is one of the major checkpoint gene involved in G2/M checkpoint, as well as involved in G1/S and Intra S arrest. We use U937 human monoblastic leukemia cell as a model to study human Chk1 RNA isoforms and transcription regulation.

Checkpoint 的功用为侦测细胞内DNA damage的发生，并藉由阻止细胞周期的进行，提供细胞足够的时间修复错误，Chk1即为其中的一种重要的基因。

Apart from involved in nociceptive transmission, SP is also involved in inflammatory responses.

SP除了参与感受伤害性刺激以外，还介导炎症反应。

Asked by Medscape Oncolo gy to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said:"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis."

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论，未参与此研究的Franklyn医师表示，这是一个重要的研究，因为它纳入了此一少见甲状腺癌的许多病患，特别是此癌症的偶发或者非遗传变化，且展现出突变与预后有关的可能性；此外，该研究有潜在的临床冲击，但是首先，这些发现需要有其他研究证实重现；这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

Asked by Medscape Oncology to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said: \"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis.\"

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论，未参与此研究的Franklyn医师表示，这是一个重要的研究，因為它纳入了此一少见甲状腺癌的许多病患，特别是此癌症的偶发或者非遗传变化，且展现出突变与预后有关的可能性；此外，该研究有潜在的临床冲击，但是首先，这些发现需要有其他研究证实重现；这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

56 cases of bullous pemphigoid were studied on the clinical characters and immunol-blot patterns.It was found that bullous pemphigoid happened mostly among old people in bullous type;Autoantigen BP230,BP230/180 and BP 230/180 combined with minor antigens involved in acute phase of BP patient;While BP180 involved mainly in the remission of the disease.

对56例江浙沪地区类天疱疮患者的临床特征和不同靶抗原的关系进行了探讨，发现类天疱疮多发于老年人，并以大疱性多见；在BP的急性期抗体结合230kD、230/180kD、合并条带靶抗原较常出现(86.11%)；而在疾病的缓解期抗体结合180kD抗原较常出现(65%)；180kD靶抗原并非次要抗原。

The identified proteins are involved in a variety of cellular process including several zinc finger proteins relevant to transcription regulation, such as zinc finger 198, 263, 14, 224, zf6, novel protein similar to transcriptional represser CTCF, and kruppel-like zinc finger protein; two members of the ADAMs (a disintegrin and metalloprotease domain) family; two members of integrin family; several proteins involved in the signal transduction, cell-cycle control, chromatin remodeling and transcription repression; and also some proteins of cell skeleton and some with unknown functions.

鉴定出 的蛋白包括多个与转录调控相关的锌指蛋白，如锌指蛋白198、263、14、224、zf6、转录抑制因子cTcF样蛋白、幻肚pple样锌指蛋白等：两个含金属蛋白酶结构域和整合素结合结构域的家族成员ADAM28和ADAM17；两个整合素家族成员pZ整合素和含十个EGF样结构域的整合素；与细胞信号转导通路有关的蛋白；与细胞周期调控有关的蛋白；与染色体重塑和基因转录抑制有关的蛋白；细胞骨架蛋白以及其他功能未明的蛋白等。

During operation, epileptogenic focus was delineated by EEG/ECoG and functional area was located by direct cortex electrical stimulation. Epileptic focus was resected if not involved the functional area, and multiple subpial transactions was performed when involved functional area.

术中通过皮层EEG对致疒间灶定位，通过皮层诱发电位及皮质电刺激定位脑功能区，对位于功能区以外的致疒间灶行切除性手术，功能区内的致疒间灶行软脑膜下横行纤维切断术。

METHODS: Collaborative meta-analyses were undertaken of 194 unconfounded randomised trials of adjuvant chemotherapy or hormonal therapy that began by 1995. Many trials involved CMF (cyclophosphamide, methotrexate, fluorouracil), anthracycline-based combinations such as FAC (fluorouracil, doxorubicin, cyclophosphamide) or FEC (fluorouracil, epirubicin, cyclophosphamide), tamoxifen, or ovarian suppression: none involved taxanes, trastuzumab, raloxifene, or modern aromatase inhibitors.

对194个开始于1995年的关于辅助化疗或激素治疗的随机试验进行meta分析，许多试验包含了CMF(环磷酰胺、氨甲喋呤、氟尿嘧啶)，蒽环药物为基础的联合化疗比如FAC(氟尿嘧啶、阿霉素、环磷酰胺)或FEC（氟尿嘧啶、表阿霉素、环磷酰胺）及他莫昔芬或卵巢去势；无一包含紫杉烷类、赫赛汀、雷洛昔芬及芳香化酶抑制剂。

In summary, we identified firstly that existence and distribution of JA and NOS in guard cell; presumed that the direct transport of JA from unwounded tissue to wounded site could account for the increase of JA after leaf wounding, and involved stomatal closure, and proposed a possible pathway of JA involved in regulating stomatal movemnts as follows: The production of NO stimulated by JA triggers the increases of cytosolic Ca〓 concentration, subsequently activate other downstream reactions and eventually induces stomatal closure.

本研究中我们首次确认了气孔保卫细胞中JA和NOS的存在和分布；伤引起的JA运输和分配的变化可能参与对气孔运动的调控，并提出JA调控气孔运动信号转导的一条可能途径：JA引起NO含量的增加，经第二信使Ca〓的作用及其下游事件，最终诱导气孔关闭。

Objective: To study the effect of polycythemia on blood oxygen saturation.

裴蕾目的：观察RBC剧增而引起的高粘血症对血氧饱和度的影响。

Based on SIMPLER algorithm in the curvilinear body-fitted coordinates, the calculations were performed for Pr=0.7, Re=10~1000 on non-orthogonal non-staggered grids which are generated by elliptic equation systems.

采用曲线坐标系下压力与速度耦合的SIMPLER算法，数值研究了周期性渐扩渐缩波纹通道内脉动流动与换热情况，流动Re数的范围为10~1000，Pr数为0.7。