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The cell cycle and apoptosis and the expression of P-pg, bcl-2, P53 in the MG63 and MG63/R cell lines were analyzed by flow cytometry. Results The resistance index of the MG63/R cells to cisplatin was 83.557±4.841. The cells also had resistance to doxorubicin, vincristin, methotrexate and cyclophosphamide. Disordered structure of the MG63/R cells was observed through microscopy. The cells appeared in triangle, polygon and polynucleation. The increase of granular endoplasmic reticulums and apophyses was observed through transmission electron microscopy. The proliferation ability of MG63/R increased significantly, with a low apoptosis index.

结果 经顺铂186d的诱导,建立了MG63/R,其对顺铂的耐药指数为83.557±4.841,对阿霉素、长春新碱、氨甲基蝶吟、环磷酰氨亦产生不同程度的交叉耐药;光镜观察可见MG63/R细胞排列不规则,形态呈三角形、多角形及多核现象;透射电镜显示MG63/R细胞表面突起增加,粗面内质网丰富;细胞周期分析显示细胞增殖能力明显增加而细胞凋亡明显降低;MG63/R细胞 P-pg、bcl-2阳性表达较MG63细胞明显增加,P53表达则明显降低。

This article has selected three methods of weight calculation: single item index method of weight; synthesis index method of weight; entropy method of weight After the expatiation of theories and means, we analyzed example by using the fuzzy comprehensive evaluation method baaed on these three kinds of methods of weight calculation, and then came to the conclusion through contrast: the first method is very sensitive to superscale; the other two methods, which consider more factors' influence, can generally reflect the real status of water quality, and the results are consistent and relatively better.

现选取了单项评价指标权重法、综合权重法以及熵权法三种不同的权重计算法,分别详述了其计算原理和方法,并在基于这三种权重计算法的基础上采用模糊综合评判法对实例进行分析,最终通过对比得出结论:基于单项评价指标权重法的模糊综合评判法对单个超标因子比较敏感;基于综合权重法和熵权法的模糊综合评判法则综合考虑了各个指标因子对评价结果的影响,能够较全面的反映水质的实际情况,评价结果几乎一致,且相对较好。

The spatial data index betakes the spatial data structure based on the improved R-Tree structure, and the property index uses the B+ tree data structure.

空间数据索引采用基于改进R-Tree的空间数据索引结构,属性数据索引采用B~+树数据结构。

As measured by the "bedside" index, the risk factors for developing dementia are an age of 70 or older, poor scores on two simple cognitive tests, slow physical functioning on everyday tasks such as buttoning a shirt or walking 15 feet, a history of coronary artery bypass surgery, a body mass index of less than 18, and current non-consumption of alcohol .

作为衡量&床边指数&的危险因素,为发展老年痴呆症是一个年届70岁或年纪大了,穷人的分数就两个简单认知测试,慢速身体功能,对日常的工作,例如buttoning衬衫或步行15英尺,历史冠状动脉搭桥手术,身体质量指数低于18岁,并且目前非食用酒精。

As measured by the "bedside" index, the risk factors for developing dementia are an age of 70 or older, poor scores on two simple cognitive tests, slow physical functioning on everyday tasks such as buttoning a shirt or walking 15 feet, a history of coronary artery bypass surgery, a body mass index of less than 18, and current non-consumption of alcohol.

这套&床边&指数所测量的发生痴呆的危险因子包括年龄超过70岁、在两项简单的认知测试中得低分、在如给衬衫钉纽扣或步行十五分钟这样的日常琐事中行动缓慢、有冠状动脉搭桥术病史、体重指数低于18、近期无饮酒。

The synthetic nourishment index method averages the trophic index of all parameters, and then evaluates the degree of the eutrophication. The total composition analysis nourishment evaluation colligates all kinds of representative parameters, and then evaluates the degree of the eutrophication. The grey system theory method evaluates the degree of the eutrophication through a series of calculations, such as constructing situation and situation matrix, confirming object degree, and so on.

总成分分析营养度评价法是通过对各单因子的分营养度进行算术平均,将水体营养状态连续分级;综合营养状态法是综合多项富营养化代表性指标,将其表示成指数,对水体营养状态连续乡级;灰色系统理论法是通过构造局势与局势矩阵、确定目标效果测度、多目标决策、确定最优局势等一系列系统分析计算,判断水体富营养化级别。

After one period of treatment, the improvement in the Scale of spasticity、the physical performance、the index of ADL,etc, are recorded. Compared with the control group, the alleviation of crura spasticity, the improvement of movement function and the index of ADL of treated group was better.

通过治疗组和对照组的对比研究,表明按摩结合康复训练对下肢痉挛状态的改善、上下肢共同运动能力的提高均优于对照组,提示了该康复方案在改善下肢痉挛状态上有效性、可行性和实用性的特点。

This model decompounds the cooperative partners of virtual enterprises as the roles of the agile supply through analyzing the business process of the agile supply chain; an agent stands for one role of the agile supply chain. We give the architecture of agent negotiation and the reasoning process model based multi-agent negotiation with fuzzy logic control after analyzing the process of multi-agent negotiation. An evaluating principle of the cooperative partners is given for this reasoning process model firstly, then, we analyze the factor, which affect the agent evaluating the cooperative partners with the principle. An evaluation index system is designed for multi-agent and multi-issue and multi-level negotiation, then, we evaluate the proposal in the agent negotiation with the index system fuzzily and synthetically and the result range from 0 to 1. This evaluation method is generic, furthermore, for the adaptability of agent, partiality of agent can be defined manually or automatically, the user can adjust the partiality with changing the weight to optimize negotiation results.

该模型在分析了敏捷供应链的业务流程的基础上将动态联盟的合作伙伴企业按角色进行分解,用Agent来代表每个角色,在分析了Agent谈判的过程之后给出了谈判Agent的体系结构,然后给出了基于模糊逻辑控制的Agent的谈判推理模型,该推理模型首先建立了合作伙伴企业评价体系的原则,并基于此原则分析了影响Agent对合作伙伴企业的评价因素,然后建立了多Agent多问题多级评价指标体系,并基于该指标体系对Agent在谈判中的建议进行模糊综合评价,评价结果是位于区间[0,1]上的值,该评价方法不仅具有通用性,而且Agent可以通过调整各级指标的权重来定义自己的偏好。

Rays,the humoral cellular and non-specific immunity in mice were all decreased. Genistein could facilitate recover all the above indices in the following aspect: lymphocyte stimulation index, delated hypersensitivity, production of antibodies, colony forming units- spleen, and spleen index.

4Gen可明显增加辐射小鼠脾淋巴细胞增殖指数、二硝基氟苯诱发耳廓肿胀率、血清溶血素水平、脾指数,使碳粒廓清指数、胸腺指数比对照组有增加的趋势。

ETFs are index funds at heart, so investors are encouraged to study the philosophy of index investing which downplays stock picking in favor of buying the market.

ETFs核心是指数基金,因此投资者被鼓励进行指数投资思想的研究,忽略股票的选择,以便于追踪市场。

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Objective To investigate the effects of interleukin-1 β converting enzyme gene on the biologic characteristics of ovarian cancer cells.

目的 探讨白细胞介素-1 β转换酶的表达,对卵巢癌细胞生物学特性的影响。

Campylobacter: This illness is the most commonly identified cause of diarrheal illness in the world.

弯曲:这种病是最常见的原因查明腹泻病,在世界上。

Gangs fill the daily lives of many of our poorest and most vulnerable citizens with a terror that the court does not give sufficient consideration, often relegating them to the status of prisoners in their own homes.

法院没有充分的考虑到黑社会的猖獗所带来的恐怖,这使得我们最穷、最可怜的市民每天生活在他们的阴影当中,成为在家的囚犯。