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The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.
研究结果:1合成的CS-PAA磁性聚合物微球呈球形,大小均一,TEM测定其干态下粒径为80nm左右,磁化曲线证实具有超顺磁性,具有一定的PH敏感性,固载表柔比星后,水溶液性状稳定,无沉淀物,DLS测定直径约200nm左右,测定载药率为15%,较文献报道高,包封率为20%。2肉眼观察试验组大鼠膀胱表面呈褐色,可见大量的Fe粒子聚集,普鲁士兰染色法显示,试验组大鼠膀胱壁内有大量的Fe粒子,分布至膀胱壁全层,与对照组大鼠相比,试验组大鼠的肝、脾内的Fe粒子聚集量明显降低;HPLC测定结果与Fe染色相同;高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高,其他组大鼠血生化指标没有明显变化。3MTT法发现,高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组,FCM发现试验药物组可引起明显的肿瘤细胞凋亡,试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C,试验组细胞Bcl-2蛋白减少,Bax蛋白变化不明显,Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P<0.01),其中高剂量组的抑制率最高。
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From the early study of the pathogenesis of pre-eclampsia people have found its association with immunological function . In 1986 Ellis et al[1] had found that the extravillous chorionic cytotrophoblast contacting with the maternal tissue expressed high levels of Human leukocyte antigen-G, a major histocompatibility tissue-specific antigen . Extravillous chorionic cytotrophoblast with high levels expression of HLA-G proteins can invade the maternal deciduas and the maternal spiral arteries by displacing the endothelial lining and destroying most of the musculoelastic tissue of these arteries .
早期研究开始,许多学者即发现其与免疫学有密切关系,至1986年Ellis等[1]发现人类白细胞抗原(human leukocyte antigen,HLA) G分子高度表达在绒毛外滋养层细胞( extravillous cytotrophoblast,EVCT)上,即浸润至子宫蜕膜层甚至达子宫浅肌层以及子宫螺旋动脉内皮层,与母血及子宫组织直接接触的滋养细胞,这种独特的组织分布提示HLA-G分子在母胎免疫耐受方面起重要作用。
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Experimental results show that the water velocity is that when the BV ammonia concentration of 50 mg, L - 1 simulation wastewater and 98 mg, L - 1 point of industrial wastewater, penetrate respectively C/C0 = 0.3 and 0.15, water column of natural zeolite could handle respectively; 126 BV, 43 BV Modified zeolite column can handle respectively 157 BV, water, and with 46 BV hydraulic load increases, zeolite column can reduce water treatment, The experiment was found to leak after 8 NaCl solution with zeolite desorption regeneration effect is good, low cost, regeneration of zeolite adsorption capacity decrescent, Test through dynamics analysis found that zeolite column of ammonia nitrogen adsorption fast.
实验结果表明,进水速度为2.72 BV时,通入氨氮浓度为50 mg·L-1的模拟废水和98 mg·L-1的工业废水,此时穿透点分别为C/C0=0.3和0.15时,得到天然沸石柱可处理水量分别为126 BV、43 BV;改性后沸石柱可处理水量分别为157 BV、46 BV,且随水力负荷增大,沸石柱可处理水量减小;试验还发现对泄露后沸石用8%NaCl溶液解吸再生效果好,成本低,再生后的沸石吸附容量变小;试验通过动力学分析发现沸石柱吸附氨氮速度较快。
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Wound healing of rat skin may be arbitrarilydivided into the following stages: wound generation, suppurating in someinflammation area, growing of granulation tissue, scab formation,decrustation, and completely healing. The wound depth and the extent ofhealing also could be determined from the OCT images in the different healingtime. Healing time for the skin scald was found to be much shorter than those ofthe skin wound. Because the skin wound is serious than the skin scalds. 3 The result of using OCT to monitor the model of acetic acid gastric ulcer in rats:Results of this experiment showed that using OCT technology can identify theulcerative gastric mucosa tissues with normal tissues, make the imaging on theunder-layer of gastric mucosa tissues, and evaluate the healing period and healingquality. From the OCT images can be clearly found the acetic acid gastric ulcer.
3大鼠胃溃疡模型的OCT成像检测结果:实验结果显示利用OCT能够实现溃疡组织的成像,可显示正常胃壁组织的层次性结构,对于溃疡病变过程中可对黏膜下病变的深度与状况进行成像分析,从图像可以很明显的发现溃疡性炎症病变区域(这个区域由于散射光变弱,颜色相对比较暗),在愈合的后期黏膜层基本愈合的状态下仍可显示黏膜下层组织的增生、未能完全愈合等病理改变。
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The manner of death was deduced comprehensively based on all above findings. Results: There were 85 cases determined as drug abuse death in Shaanxi area from Oct. 1995 to Oct. 2001, including 63 males and 22 females. 70% of the subjects detected in postmortem biological samples were heroin /morphine. Hyperaemia, edema, hemorrhage and arteriolar sclerosis of multi-organs; cells denature and necrosis; foreign body in pulmonary, as well as needle puncture tracks on skin and dermapostasis, were common pathological observations. Incidences of tuberculosis(21%),cirrhosis(12%) and hepatitis(9%) were higher than those found in general autopsy population. No AIDS case was found.
结果··:陕西地区1995年-2001年有85例经法医鉴定为药物滥用死亡,其中男63例,女22例;尸体血液、脏器、毛发内检出的滥用药物70 %是海洛因/吗啡;多药混合滥用特点明显;最常见的病理变化包括:多脏器淤血、水肿、出血、小动脉硬化,细胞变性、坏死,肺内异物及皮肤注射针眼、脓肿等;常见合并的传染性疾病依次为:结核病(21 %)、肝硬化(12 %)和病毒性肝炎(9 %)等,AIDS未检出。
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Experiments were conducted for testing root tensile strength and measuring root cellulose content of Medicago sativa and Digitaria sanguinalis. Results indicated that in the two species, both the tensile strength and percentage of cellulose were negatively correlated with root diameter, while a positive correlation was found between percentage of cellulose and tensile strength. The conclusion confirmed that the relationship among root tensile strength, root diameter and root cellulose content found in tree root system was held also in the two species.
对豆科的紫花苜蓿和禾本科的马唐根的抗拉力和纤维素含量的研究表明,根的抗拉强度和纤维素含量均与直径呈显著的负相关关系,根的抗拉强度与纤维素含量呈正相关关系,表明&木本植物根的抗拉强度、直径和纤维素含量关系&的研究结论在这两种草本植物上也同样适用。
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The candidate s doubtful past he has a dubious record indeed what one found uncertain the other found dubious or downright false it was more than dubitable whether the friend was as influential as she thought - Karen Horney .
候选人可疑的过去;他有确实可疑的纪录;一个人发现是可疑而其他人发现是可疑的或明显虚假的东西;这个朋友是否像他所认为的那样有影响力这不仅是可疑的-凯闰·好妮。
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Polymorphic sites were found only in Yorkshire, Landrace, Duroc and their hybrids, but that were not found in Mm pig and wild pig.
仅在大白猪、长白猪,杜洛克和杂种猪中发现多态性位点,而在民猪和野猪中未发现。
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The mean birth weight and gestational age was (1256.3±196.8) g and (29.583 3±1.543 6) weeks in ROP group, and (1337.8±146) g and (31.217 4±2.430 6) weeks in control group, respectively. In 39 ecdemic infants, 32 were found with ROP (82.1%, 1 with mild and 31 with severe ROP) while in 91 local infants, 28 were found with ROP (30.8%, 15 with mild and 13 with severe ROP).
ROP组平均出生体重(1256.3±196.8)g及平均孕周(29.583 3±1.543 6)周,而正常眼底组平均出生体重(1337.8±146)g、平均孕周(31.217 4±2.430 6周。39例外地患儿中早产儿视网膜病变32例占82.1%(轻度ROP 1例,重度ROP 31例),91例北京患儿中早产儿视网膜病变28例占30.8%(轻度ROP 15例,重度ROP 13例)。
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Results:Three cases had transection injury of biliary duct.1 case was found during the operation and 2 cases were found after the operation.1 case received bile duct repair and T tube supporting and drainage;2 cases underwent chole enteroanastomosis.
结果:胆管横断性损伤3例,术中发现1例,术后发现2例;胆管修补+T管支撑引流1例,胆肠Roux en Y吻合2例。
- 相关中文对照歌词
- I Found Love
- Claimed
- Found
- Lost & Found
- I Found Love (Cindy's Song)
- I Found You
- Love You Better
- I Found Love With You
- Let's Get It
- I Found You
- 推荐网络例句
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You'll be in trouble it you don't watch out .
如果你不注意,你会有麻烦的。
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Shaped like a biconvex lens.Of, relating to, or having the form of a hyperbola.
双曲线的属于双曲线的,与之有关的,或有双曲线形状的
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Laser's main feature is the output is big, the energy conversion efficiency is high, the output wavelength happen to is in the atmospheric window.
激光的主要特点是产量大,在能量转换效率高,输出波长正好是大气窗口。