查询词典 float downstream

Shh, its receptors Ptc, and downstream signal Smoothened are expressed in primitive and mature CD34+CD38+Lin- and mature CD19+, CD33+ and CD3+ cell populations.

Shh蛋白，Ptc 与下游讯息分子Smoothened，会表现在原始的CD34+CD38+Lin-细胞株上，在成熟的CD19+， CD33+与CD3+细胞株上也可见。

It is conceivable that MAJN acts upon signalers downstream of apoptosis and then inhibit apoptosis through regulation of their protein levels or activities.

可能是由于MAJN作用于细胞凋亡过程中较为下游的信号分子，并通过调控它们蛋白质含量或活性以对抗细胞凋亡。

According to the basic principles of International Water Law,"Agreement on the Cooperation for the Sustainable Development of the Mekong River Basin"signed by four riparians of Lower Mekong which will affect the development of Mekong River,and the effects are analyzed in detailed,it is considered that the downstream countries will getmore benefits and have less obligations according to the Agreement,but the upstream countries areon the contrary,at same time,some of articles in the Agreement have ambiguous means so as toaffect the implementation,like as the articles of"Decision of Joint Committee","WaterUtilization and Inter-Basin Diversions","Emergency Situations"and so on,the rules will affectthe development of Lancang River Basin,likes:information sharing,international cooperation,water pollution and so on.

一些条款规定精确性不够将影响其可操作性，如&湄委会的决议&条款、&水资源利用及流域间分流规定&、&紧急情况&等。协定可能影响我国澜沧江流域开发的主要条款有：资料共享、国际合作、水污染、否决权及已有项目自然有效问题等。

In mammals the Notch gene family comprise four related genes, Notch1-4, as the Notch ligands that encode transmembrane proteins. Ligand-receptor interaction mediated Notch activation ultimately leads to the conversion of effectors-CSL CBF1, Su(H, Lag-1 proteins, from repressors to transcriptional activators, and subsequent up-regulation of downstream targets.

在哺乳动物中，Notch基因家族包含了4个相关的基因，分别为Notch-1至-4，和Notch受质蛋白一样能被转译成膜蛋白；受质-受体间相互作用所引起Notch受体蛋白的活化会促使作用蛋白-CSL CBF1， Su(H， Lag-1 蛋白扮演抑制分子或者是转录活化分子上的角色改变，并且进一步地正向调节下游的标的基因。

As a downstream piping system when the valve opens, reflux valve, when closed, the main medium used to prevent backflow to prevent the pump and drive motor reversal, as well as a container medium discharge; currently the most commonly used is the valve flap around the body Swing Pin rotation flap valve and the valve body along the vertical axis to move lift check valve, but the above two kinds of structures exist in the valve closed, medium speed back quickly from the largest drop to zero, inlet side of the pipe resulted in the rapid pressure rise, resulting Proportional Pressure Reducing Valves in damaging effects on the piping system of water hammer phenomenon, it is generally a diameter of valve production of 50 ~ 500 mm.

止回阀作为管道系统顺流时开启，逆流时关闭的阀门，主要用于防止介质倒流，防止泵及驱动电机反转以及容器内介质泄放；目前使用最普遍的是阀瓣围绕阀体销轴旋转的旋启式止回阀和阀瓣沿着阀体垂直中心线移动的升降式止回阀，但以上2种结构的阀门均存在关闭时介质倒流速度从最大迅速降为零，致使管道进水管一侧内压迅速升高，从而产生对管路系统有破坏作用的水锤现象，所以一般止回阀生产口径为50～500 mm。

And a fluorescence molecule beacon probe is designed between upstream and downstream priers, 5' end of probe can mark fluorescence reporter group FAM, and the 3' end markes fluorescence quenching group DABCYL, and 5' end and 3' end of the probe have 6 bases which can be reflected and complemented to make fluorescence molecule beacon probe do not give out fluorescence signal in free state.

在上下游引物中间设计一条荧光分子信标探针，探针的5'端标记荧光报告基团FAM，3'端标记荧光淬灭基团DABCYL，探针的5'端和3'端有6个碱基能反折互补，使荧光分子信标探针在游离状态下不发出荧光信号。

After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific cancer cells -- those with increased expression of a protein known as E2F and/or activation of signaling downstream of a protein known as EGFR.

在选择高度特异性痘状病毒后才能有效的到达肿瘤生长地方，然后通过静脉途径给老鼠。这些病毒都是研究人员设计好的以至于只能到达特异性肿瘤细胞，像那些增加表达蛋白E2F和信号下游活化蛋白EGFR。

After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific cancer cells -- those with increased expression of a protein known as E2F and/or activation of signaling downstream of a protein known as EGFR.

以毒攻毒：设计病毒，攻击肿瘤一种新的治疗癌症的方法正在开发中：用病毒感染肿瘤杀死癌细胞留下正常细胞不被伤害。这些病毒以病毒疗法而著称。在一项新的研究当中，David Kirn 和他在旧金山Jennerex生物疗法同事已经描述出利用新病毒疗法后老鼠和兔子抗肿瘤效应的发展。在选择高度特异性痘状病毒后才能有效的到达肿瘤生长地方，然后通过静脉途径给老鼠。

These results suggested that the function of each function domain in HIV 1 LTR exhibited distinct characteristics on gag gene expression in vaccinia virus:(1) The function of intact LTR on gag gene expression varied with the upstream poxvirus promoter;(2) NR sequence neither decreased nor increased the Gag protein exprssion level;(3) Enhancer sequence might not be recognized by recombinant vaccinia virus expression system;(4) TAR sequence enhanced Gag protein expression effectively;(5) U5 region and its downstream non translated sequence had little effect on

免疫印迹和免疫酶试验检测均表明，6株重组病毒的Gag蛋白表达量因LTR不同而有明显差异，表明HIV1的LTR及其下游基因置于痘病毒启动子控制下，在痘苗病毒中表达时有下述特点：（1）不同的痘苗病毒启动子与全长LTR相互作用，对gag基因表达有显著不同的调控效果；（2）NR序列对Gag蛋白表达没有明显影响；（3）EN序列不能被重组痘苗病毒表达系统识别；（4）TAR序列可提高Gag蛋白的表达量；（5）U5区及下游非翻译序列不影响Gag蛋白的表达。

Our results indicate that the RNA species may be regulated by PKC downstream signals related to the MAP kinase cascade. We observed E1 contains RNA increase in the polysome after induction of U937 differentiation.

我们分别对两者进行研究，发现含有Exon N1的Chk1 transcript可能以直接或间接的方式受p53的抑制；而含有Exon 1的Chk1 transcript的调控机制较不清楚，仅知可能是由PKC下游的讯息传递所调控，且可能和MAP kinase cascade有所关联。

Chimborazo and Cotopaxi, took me by the hand.

越过琴博腊索山和科托帕克西山。

This car is in a good condition.

这辆车的状况很好。