查询词典 effectiveness

In order to overcome the problem of multidrug resistance in human epidemic carcinomata anti-adriamycin cells (KB-A-1), the antisense and antigene oligonucleotides were used to investigate their effectiveness on inhibiting the mdr1 gene expression. The effectiveness of antisense or antigene oligonucleotide on inhibiting the multidrug resistance was detected by MTT colometric assay and ELISA.

中文题名反义与反基因寡核苷酸及其萘二酰亚胺偶联物对靶基因表达的抑制作用研究副题名外文题名 The inhibition of the targeted gene expression by the antisense or antigene oligonucleotides and their naphthylimide-conjugated derivatives 论文作者李军生导师张元兴魏东芝教授学科专业生物化工研究领域\研究方向生物化学与分子生物学学位级别博士学位授予单位华东理工大学学位授予日期2001 论文页码总数106页关键词基因表达基因治疗反义寡核苷酸反基因寡核苷酸核酸馆藏号BSLW /2001 /Q78 /264 针对人表皮癌抗阿霉素细胞株（KB-A-1）的多药抗药性问题，本文从反义核酸和反基因核酸角度，通过MTT法检测细胞生长情况，ELISA法检测基因表达产物P-gp表达水平的变化，对寡核苷酸抑制肿瘤细胞MDR1基因表达的机制进行了探讨。

Althought this surgery has been reported by a few doctors recently, the safety and effectiveness need to be evaluated in further studies. In our study, the approach of the chorioretinal venous anatomosis in the model eyes with branch retinal vein occlusion, are induced by different surgical anastomosis procedures, in order to invest the effectiveness and safety and make a pilot clinic treatment exploration. Methods and materials The study was divided two ports: animal experiment and clinical study.

这种治疗方法的可行性和疗效评价，在激光诱导脉络膜视网膜静脉吻合术治疗非缺血型CRVO病人中得到证实；而对缺血型CRVO，由于病情严重，晚期新生血管并发症产生的危险性高，或者已有产生，因此最近开展的用玻璃体切除联合手术吻合脉络膜视网膜静脉的外科治疗作为最新的探索性治疗方法，在国外已见少数病例报告，但是尚需要进一步的研究观察来评价其可行性、安全性和疗效。

It first introduces the status quo and special background of diversification in China's listed companies, then analyses explanative effectiveness of above motivation theory on diversification in China's background and finally draw a conclusion that Agency Theory has highly explanative effectiveness on diversification in Chinese listed companies.

在分析我国上市公司多元化现状及特殊背景的基础上，分析这些背景如何影响动因理论对我国投资多元化的解释效力，最后得出结论：代理理论动因对于我国上市公司的多元化投资现象有着普遍的解释效力。

Results The value of NAA and Cho/Cr was decreased obviously.The NAA value,between benign and malignant tumor and between intracerebral and extracerebral tumor,had significant effectiveness.But the Cho and Cr value and the peak ratio of metabolites had no significant effectiveness between benign and malignant tumor and between intracerebral and extracerebral tumor.

结果：几乎所有颅脑肿瘤的NAA峰均下降，Cho/Cr下降；良恶性肿瘤之间、脑内外肿瘤之间的NAA峰值的比较差异有显著性，但其Cho、Cr峰值的比较及各代谢产物的峰值比值的比较差异无显著性。

At the one-cell stage, each embryo was injected with gradient doses of 2-8ng MO. The control morpholino, was purchased from Gene-Tools.To test the knockdown effectiveness of the morpholino, the tbx2-EGFP (enhanced green fluorescent protein) construct was generated. And coinjection of morpholino with mRNA tests its specificity of the morpholino. Overexpression of tbx2 via mRNA microinjection helps us understand gaining function of tbx2. Results The tbx2-EGFP construct tests the knockdown effectiveness of the morpholino. Zebrafish embryos lacking tbx2 function have defects in cardiac contractility, rhythm and morphology in a dose-dependent manner. The embryos with c-MO are normal in development. Coinjection of morpholino with mRNA rescue the phenotype of tbx2 knocking down. The phenotypes include pericardial edema, hypogenetic ventricle, dilation of atria, arrhythmia, bradycardia, asystole, abnormal atrioventricular canal, aberrant valve and blood regurgitation.

结果荧光蛋白融合标记实验验证了tbx2-MO可以很好得阻抑斑马鱼胚胎tbx2的表达，tbx2-MO组胚胎在心脏收缩性、节律和形态学发生上出现了异常，心脏畸形随着注射剂量的增加而出现比较一致的表型，而c-MO组胚胎没有出现明显的畸形；tbx2-mRNA和tbx2-MO的共注射减少了tbx2-MO胚胎心脏畸形的发生率及减轻了心脏畸形的程度，验证了所设计合成的tbx2-MO对tbx2基因的抑制作用具有特异性；tbx2-MO组胚胎心脏缺陷包括心室发育不良、心房扩张、房室管和瓣膜异常以及心率缓慢、心律不齐、心脏停搏、血液返流等，并根据心脏发育异常的程度分为轻、中、重度畸形组tbx2-mRNA基因过表达胚胎没有见到心腔的形成。

"Cryoablation has been in use for many years," commented Dr. Georgiades. However, it is only in the past 9 years that the technology has led to probes small enough to be used percutaneously, with imaging now available to guide probe placement and to monitor the procedure."It is just now that we are, for the first time, establishing the safety and effectiveness of this procedure in kidney cancer," Dr. Georgiades told Medscape Oncology . Cryoablation is also used for other cancers, such as lung, liver, and bone, but there are few data on the effectiveness of cryoablation in these other tumors, he said.

Georgiades博士表示，冷冻疗法已经被运用多年，不过，只有在过去9年因为探针缩小才可以经皮穿刺使用，现在还有影像可以导引探针放置与监控手术；Georgiades博士向Medscape肿瘤学表示，这是我们现在有的技术，这是第一次建立安全与有效的肾脏癌手术；冷冻疗法也可用於其他癌症，例如肺、肝、骨癌，但冷冻疗法用於其他癌症的效果的资料不多。

In discussing the effectiveness of leaders, management scholar Louis Pondy (1978) emphasized that leaders' effectiveness lies in their "ability to make activity meaningful" for others; leaders "give others a sense of understanding what they are doing."

管理学者Louis Pondy(1978)在探讨领导者效率时强调，领导者效率取决于是否具有&使活动对他人显得富有意义的能力&，领导者&要让他人理解自己在所干何事&。

In discussing the effectiveness of leaders, management scholar Louis Pondy (1978) emphasized that leaders' effectiveness lies in their "ability to make activity meaningful" for others; leaders "give others a sense of understanding what they are doing."

领袖就要承担管理风险。我们扮演着领袖的角色，其实，通过自身能力抽身于纷繁复杂的状况之外来解释目标并进行沟通对话时，我们就成为领导者了。沟通实际上就在做领袖的工作。

This paper reviews the effectiveness of monetary policy in China, including open market operation, reserve system reformation, interest rate policy, reloan and rediscount policy and credit policy and so on, and finds out that monetary policy operation has endogenesis and dependence, and the effectiveness of monetary policy is not perfect.

三是全面述评我国货币政策实践情况，包括公开市场操作、准备金制度改革、利率政策、再贷款再贴现、信贷窗口指导等政策工具实践情况，发现我国货币政策操作内生性强，自主性弱，货币政策执行效应并不理想。

The analysis of effectiveness on policy making and implementation of Slopping Land Conversion Program is important as the evaluation of effectiveness is always a vital part in program appraises.

费用有效性评价是工程评价的重要方面，从政策制定和执行角度对退耕还林的费用有效性及其影响因素进行分析，具有重要的意义。

Objective:To compare the response control and attention of Schizophrenic patients with that of the healthy controls by Integrated Visual and Auditorycontinuous performance test. To quantitate the impairment of cognitive function in patients, and to explore the relationship between cognitive function and the severity of the disorder.

目的：探讨精神分裂症病人在IVA持续操作测试中的反应控制能力、注意力等，并与健康人进行比较，从而量化精神分裂症病人的认知功能损害，并进一步探讨其认知功能与疾病严重程度的关系。

Main effective factors including subcooling degree, mechanical vibration, gas hydrate reformation, environment temperature, noncondensing gas and surfactant are analyzed.

指出过冷度、机械振动、重复生成水合物、环境温度、不凝性气体、添加剂是影响气体水合物生成的主要因素，还对R152a水合物的放冷进行了实验研究。